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Results: 199
Dynamic exchange of myosin VI on endocytic structures.
The actin-based molecular motor myosin VI functions in the endocytic uptake pathway, both during the early stages of clathrin-mediated uptake and in later transport to/from early endosomes. This study uses fluorescence recovery...
Design of I-II-IV-VI semiconductors through element substitution
Through element substitution in CuZnSnS, a class of kesterite-structured I-II-IV-VI semiconductors can be designed as novel functional materials. Using the first-principles calculations, we show that this element-substitution...
Design of I-II-IV-VI semiconductors through element substitution
Through element substitution in CuZnSnS, a class of kesterite-structured I-II-IV-VI semiconductors can be designed as novel functional materials. Using the first-principles calculations, we show that this element-substitution...
Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin.
Vanesa M Tomatis, Andreas Papadopulos, Nancy T Malintan, Sally Martin, Tristan Wallis, Rachel S Gormal, John Kendrick-Jones, Folma Buss, Frédéric A Meunier
Aug 14, 2020
Before undergoing neuroexocytosis, secretory granules (SGs) are mobilized and tethered to the cortical actin network by an unknown mechanism. Using an SG pull-down assay and mass spectrometry, we found that myosin VI was...
Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.
During constitutive secretion, proteins synthesized at the endoplasmic reticulum (ER) are transported to the Golgi complex for processing and then to the plasma membrane for incorporation or extracellular release. This study...
Biological Transport Cell Cycle Proteins Cell Membrane Endoplasmic Reticulum Exocytosis Fluorescent Antibody Technique Gene Knockdown Techniques Golgi Apparatus HeLa Cells Humans Immunoblotting Membrane Fusion Membrane Proteins Membrane Transport Proteins Microscopy Fluorescence Myosin Heavy Chains Nuclear Proteins RNA Small Interfering secretory pathway Secretory Vesicles Transcription Factor TFIIIA
Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis.
Daniela A Sahlender, Rhys C Roberts, Susan D Arden, Giulietta Spudich, Marcus J Taylor, J Paul Luzio, John Kendrick-Jones, Folma Buss
Aug 27, 2020
Myosin VI plays a role in the maintenance of Golgi morphology and in exocytosis. In a yeast 2-hybrid screen we identified optineurin as a binding partner for myosin VI at the Golgi complex and confirmed this interaction in a...
Animals Biological Transport CHO Cells Cell Cycle Proteins Chickens Cricetinae Exocytosis Gene Expression Golgi Apparatus HeLa Cells Humans Huntingtin Protein Membrane Glycoproteins Membrane Transport Proteins Myosin Heavy Chains Nerve Tissue Proteins Nuclear Proteins Protein Binding RNA Interference Transcription Factor TFIIIA Transport Vesicles Two-Hybrid System Techniques Viral Envelope Proteins rab GTP-Binding Proteins
Myosin VI is required for sorting of AP-1B-dependent cargo to the basolateral domain in polarized MDCK cells.
In polarized epithelial cells, newly synthesized membrane proteins are delivered on specific pathways to either the apical or basolateral domains, depending on the sorting motifs present in these proteins. Because myosin VI has...
Adaptor Protein Complex 1 Amino Acid Motifs Animals Cell Cycle Proteins Cell Line Cell Polarity Dogs Endosomes Humans Membrane Glycoproteins Membrane Transport Proteins Mutagenesis Site-Directed Myosin Heavy Chains Protein Isoforms Protein Transport Transcription Factor TFIIIA Viral Envelope Proteins
Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis.
Tissue expression microarrays, employed to determine the players and mechanisms leading to prostate cancer development, have consistently shown that myosin VI, a unique actin-based motor, is upregulated in medium-grade human...
Adaptor Proteins Signal Transducing Apoptosis Regulatory Proteins Blotting Western Cell Line Cell Line Tumor Endocytosis Endosomes Gene Expression Golgi Apparatus Green Fluorescent Proteins HeLa Cells Humans Male Membrane Proteins Microscopy Fluorescence Microscopy Immunoelectron Myosin Heavy Chains Prostate-specific antigen Prostatic Neoplasms Protein Binding Protein Serine-Threonine Kinases RNA Interference Recombinant Fusion Proteins Transfection Tumor Suppressor Proteins Vascular Endothelial Growth Factor A
Re-evaluating herd protection by Vi typhoid vaccine in a cluster randomized trial.
Mohammad Ali, Dipika Sur, Suman Kanungo, Firdausi Qadri, Deok Ryun Kim, Taufiqul Islam, Justin Im, Faisal Ahmmed, Yun Chon, Ashraful Islam Khan, K Zaman, Florian Marks, Shanta Dutta, Sujit K Bhattacharya, John D Clemens
Nov 26, 2019
BACKGROUND: In a cluster randomized trial (CRT) of a Vi polysaccharide vaccine against typhoid in the slums of Kolkata we found evidence of vaccine herd protection. However, transmission of typhoid into clusters from the outside...
Clinical trial registration: ClinicalTrials.gov NCT00125008 Vi polysaccharide vaccine Cluster randomized trial fried egg design Typhoid Fever vaccine effectiveness Adolescent Adult Child Child Preschool Cluster Analysis Female Humans Immunity Herd india Male Poverty Areas Typhoid Fever Typhoid-Paratyphoid Vaccines
Myosin VI and optineurin are required for polarized EGFR delivery and directed migration.
The polarized trafficking of membrane proteins into the leading edge of the cell is an integral requirement for cell migration. Myosin VI and its interacting protein optineurin have previously been shown to operate in...
The localization of myosin VI at the golgi complex and leading edge of fibroblasts and its phosphorylation and recruitment into membrane ruffles of A431 cells after growth factor stimulation.
Myosin VI is an unconventional myosin that may play a role in vesicular membrane traffic through actin rich regions of the cytoplasm in eukaryotic cells. In this study we have cloned and sequenced a cDNA encoding a chicken...
Actins Amino Acid Sequence Animals Cell Line Cell Membrane Chickens Endocytosis Epidermal Growth Factor FIBROBLASTS Golgi Apparatus Humans Intracellular Membranes Kidney Liver Microscopy Immunoelectron microvilli Molecular Sequence Data Myosins Phosphorylation Protein Serine-Threonine Kinases Rats Sequence Alignment Sequence Homology Amino Acid Tumor Cells Cultured p21-Activated Kinases
Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria.
Antonina J Kruppa, Chieko Kishi-Itakura, Thomas A Masters, Joanna E Rorbach, Guinevere L Grice, John Kendrick-Jones, James A Nathan, Michal Minczuk, Folma Buss
Mar 14, 2018
Mitochondrial quality control is essential to maintain cellular homeostasis and is achieved by removing damaged, ubiquitinated mitochondria via Parkin-mediated mitophagy. Here, we demonstrate that MYO6 (myosin VI), a unique...
Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke
Isuru Induruwa, Harriet McKinney, Carly Kempster, Patrick Thomas, Joana Batista, Jean-Daniel Malcor, Arkadiusz Bonna, Joanne McGee, Elaine Bumanlag-Amis, Karola Rehnstrom, Sophie Ashford, Kenji Soejima, Willem Ouwehand, Richard Farndale, Kate Downes, Elizabeth Warburton, Masaaki Moroi, Stephanie Jung
Feb 18, 2022
Treatment of Prodcued Water Using Ferrate (VI) and Directional Solvent Extraction
Sean X. Thimons
May 01, 2021
Oil field fracking operations creates by-product “produced water” that is highly variable in composition and difficult to treat. This study aims to examine two novel treatment processes together in improving the quality of a...
Published by: Digital Commons @ Texas A&M University-San Antonio
Synthesis and X-ray crystal structure of a Molybdenum(VI) Schiff base complex
Hamed Mahmoudi, Mojtaba Bagherzadeh, Saeed Ataie, Reza Kia, Seyed Heydar Moravej, Maryam Zare, Paul R. Raithby, Francesco Ferlin, Luigi Vaccaro
Oct 01, 2020
A targeted new dioxo molybdenum(VI) ONO Schiff base complex was prepared for catalyzing epoxidation of olefins in water. This complex was characterized by FT-IR, NMR, UV–Vis, and X-ray crystallography techniques. DFT...
Crystal structure DFT study Epoxidation in water Mo(VI) Schiff base Sustainable catalysis /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1604 name=Inorganic Chemistry /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Lattice-mismatched heteroepitaxy of IV-VI thin films on PbTe(001)
The chalcogenides of tin and lead (SnS, SnSe, SnTe, PbS, PbSe, and PbTe) have applications ranging from solar cells to thermoelectrics. Taking rocksalt structured PbTe(001) as the substrate, we explore the coherent...
Treatment of Prodcued Water Using Ferrate (VI) and Directional Solvent Extraction
Sean X. Thimons
May 01, 2021
Oil field fracking operations creates by-product “produced water” that is highly variable in composition and difficult to treat. This study aims to examine two novel treatment processes together in improving the quality of a...
Published by: Digital Commons @ Texas A&M University-San Antonio
Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke
Isuru Induruwa, Harriet McKinney, Carly Kempster, Patrick Thomas, Joana Batista, Jean-Daniel Malcor, Arkadiusz Bonna, Joanne McGee, Elaine Bumanlag-Amis, Karola Rehnstrom, Sophie Ashford, Kenji Soejima, Willem Ouwehand, Richard Farndale, Kate Downes, Liz Warburton, Masaaki Moroi, Stephanie Jung
Jan 28, 2022
Synthesis and X-ray crystal structure of a Molybdenum(VI) Schiff base complex
Hamed Mahmoudi, Mojtaba Bagherzadeh, Saeed Ataie, Reza Kia, Seyed Heydar Moravej, Maryam Zare, Paul R. Raithby, Francesco Ferlin, Luigi Vaccaro
Oct 01, 2020
A targeted new dioxo molybdenum(VI) ONO Schiff base complex was prepared for catalyzing epoxidation of olefins in water. This complex was characterized by FT-IR, NMR, UV–Vis, and X-ray crystallography techniques. DFT...
Crystal structure DFT study Epoxidation in water Mo(VI) Schiff base Sustainable catalysis /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry /dk/atira/pure/subjectarea/asjc/1600/1604 name=Inorganic Chemistry /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Lattice-mismatched heteroepitaxy of IV-VI thin films on PbTe(001)
The chalcogenides of tin and lead (SnS, SnSe, SnTe, PbS, PbSe, and PbTe) have applications ranging from solar cells to thermoelectrics. Taking rocksalt structured PbTe(001) as the substrate, we explore the coherent...
Treatment of Prodcued Water Using Ferrate (VI) and Directional Solvent Extraction
Sean X. Thimons
May 01, 2021
Oil field fracking operations creates by-product “produced water” that is highly variable in composition and difficult to treat. This study aims to examine two novel treatment processes together in improving the quality of a...
Published by: Digital Commons @ Texas A&M University-San Antonio
Loss of myosin VI expression affects acrosome/acroplaxome complex morphology during mouse spermiogenesis†.
During spermiogenesis in mammals, actin filaments and a variety of actin-binding proteins are involved in the formation and function of highly specialized testis-specific structures. Actin-based motor proteins, such as myosin Va...
Detection of Salmonella Typhi nucleic acid by RT-PCR and anti-HlyE, -CdtB, -PilL, and -Vi IgM by ELISA at sites in Ghana, Madagascar and Ethiopia.
Ursula Panzner, Ondari Daniel Mogeni, Yaw Adu-Sarkodie, Trevor Toy, Hyon Jin Jeon, Gi Deok Pak, Se Eun Park, Yeetey Enuameh, Ellis Owusu-Dabo, Trinh Van Tan, Abraham Aseffa, Mekonnen Teferi, Biruk Yeshitela, Stephen Baker, Raphael Rakotozandrindrainy, Florian Marks
Oct 02, 2022
BACKGROUND: We aimed to assess the prevalence of Salmonella Typhi through DNA and IgM-antibody detection methods as a prelude to extended surveillance activities at sites in Ghana, Madagascar, and Ethiopia. METHODS: We performed...
ELISA febrile illness HlyE-/CdtB-/PilL-/Vi-antigen salmonella SURVEILLANCE Adolescent Corneal Dystrophies Hereditary Enzyme-Linked Immunosorbent Assay Ethiopia Female Fever Ghana Humans Immunoglobulin M Madagascar Male Nucleic Acids Reverse Transcriptase Polymerase Chain Reaction salmonella Salmonella typhi Typhoid Fever
Galactic Winds across the Gas-rich Merger Sequence. I. Highly Ionized N v and O vi Outflows in the QUEST Quasars*
Abstract
This program is part of QUEST (Quasar/ULIRG Evolutionary Study) and seeks to examine the gaseous environments of z ≲ 0.3 quasars and ULIRGs as a...
Sylvain Veilleux, David SN Rupke, Weizhe Liu, Anthony To, Margaret Trippe, Todd M Tripp, Fred Hamann, Reinhard Genzel, Dieter Lutz, Roberto Maiolino, Hagai Netzer, Kenneth R Sembach, Eckhard Sturm, Linda Tacconi, Stacy H Teng
Feb 11, 2022
Double Diffusion As a Driver of Turbulence in the Stratified Boundary Layer Beneath George VI Ice Shelf
Abstract: Warmer and more persistent intrusions of Circumpolar Deep Water (CDW) onto the West Antarctic Peninsula are a key driver of the recent increase in ice shelf mass loss. The relatively warm and salty CDW is thought to be...
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