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Results: 48
Pathogen genomic surveillance of typhoidal Salmonella infection in adults and children reveals no association between clinical outcomes and infecting genotypes.
Carl D Britto, Sitarah Mathias, Ashish Bosco, Zoe A Dyson, Gordon Dougan, Savitha Raveendran, VL Abin, Sanju Jose, Savitha Nagaraj, Kathryn E Holt, Andrew J Pollard
Sep 21, 2020
BACKGROUND: India is endemic for enteric fever, and it is not known whether the variations in clinical manifestations between patients are due to host, environmental or pathogen factors.Blood culture surveillance was conducted...
Accuracy of self-report of HIV viral load among people with HIV on antiretroviral treatment.
J Sewell, M Daskalopoulou, F Nakagawa, FC Lampe, S Edwards, N Perry, E Wilkins, R O'Connell, M Jones, S Collins, A Speakman, AN Phillips, AJ Rodger, Sexual Transmission Risk and Attitudes (ASTRA) Study Group Antiretrovirals
Mar 27, 2019
OBJECTIVES: The aim of the study was to assess, among people living with HIV, knowledge of their latest HIV viral load (VL) and CD4 count. METHODS: Agreement between self-report and clinic record was assessed among 2771...
CD4 count HIV knowledge HIV viral load accuracy of self-report engagement in care medical record Socioeconomic status Adult Aged Anti-Retroviral Agents CD4 Lymphocyte Count Cross-Sectional Studies Female HIV Infections Humans Male Middle Aged Self Report Surveys and Questionnaires United Kingdom Viral Load Young Adult
Understanding the Enabling and Constraining Factors in Using the Virtual Lab
It is commonly accepted that learners gain better understanding of science concepts when they perform ‘hands-on' experiments in the lab. However, the lack of lab infrastructure, particularly in most rural schools, negatively...
Published by: IGI Global Scientific Publishing
Hepatomegaly Associated with Non-Obstructive Sinusoidal Dilation in Experimental Visceral Leishmaniasis.
Kota Maeda, Sonya Sadoughi, Ayako Morimoto, Kazuyuki Uchida, James K Chambers, Chizu Sanjoba, Junya Yamagishi, Yasuyuki Goto
Oct 21, 2021
Visceral leishmaniasis (VL) is the most severe form of leishmaniasis caused by protozoan parasites of the genus Leishmania. Hepatomegaly is one of the most frequent clinical manifestations of VL, whereas immunopathology of the...
Integrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent.
Bart Cuypers, Maya Berg, Hideo Imamura, Franck Dumetz, Géraldine De Muylder, Malgorzata A Domagalska, Suman Rijal, Narayan Raj Bhattarai, Ilse Maes, Mandy Sanders, James A Cotton, Pieter Meysman, Kris Laukens, Jean-Claude Dujardin
Apr 12, 2019
Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in...
Effectiveness and efficiency of two distinct mechanisms for take-off in a derbid planthopper insect.
Analysis of the kinematics of take-off in the planthopper Proutista moesta (Hemiptera, Fulgoroidea, family Derbidae) from high-speed videos showed that these insects used two distinct mechanisms involving different appendages....
Cryptotephra as a dating and correlation tool in archaeology
A new development in archaeological chronology involves the use of far travelled volcanic ash which may form discrete but invisible layers within a site's stratigraphy. Known as cryptotephra, these horizons can provide isochrons...
Validation of a mixture of rK26 and rK39 antigens from Iranian strain of Leishmania infantum to detect anti-Leishmania antibodies in human and reservoir hosts.
Bibi Razieh Hosseini Farash, Mehdi Mohebali, Bahram Kazemi, Abdolmajid Fata, Homa Hajjaran, Behnaz Akhoundi, Reza Raoofian, Pietro Mastroeni, Elham Moghaddas, Azad Khaledi, Ghodratollah Salehi Sangani
Jul 22, 2022
Mediterranean type of visceral leishmaniasis (VL) is a zoonotic parasitic infection. Some provinces of Iran are endemic for VL while other parts are considered as sporadic areas. This study aimed to assess a combination of...
Validation of a mixture of rK26 and rK39 antigens from Iranian strain of Leishmania infantum to detect anti-Leishmania antibodies in human and reservoir hosts.
Bibi Razieh Hosseini Farash, Mehdi Mohebali, Bahram Kazemi, Abdolmajid Fata, Homa Hajjaran, Behnaz Akhoundi, Reza Raoofian, Pietro Mastroeni, Elham Moghaddas, Azad Khaledi, Ghodratollah Salehi Sangani
Jun 29, 2022
Mediterranean type of visceral leishmaniasis (VL) is a zoonotic parasitic infection. Some provinces of Iran are endemic for VL while other parts are considered as sporadic areas. This study aimed to assess a combination of...
Care home residents admitted to hospital through the emergency pathway
BACKGROUND: Routinely collected hospital information could help to understand the characteristics and outcomes of care home residents admitted to hospital as an emergency. METHODS: This retrospective 2-year service evaluation...
Structural evidence of quercetin multi-target bioactivity
Diego Carvalho, Margot Paulino, Fabio Polticelli, Florencia Arredondo, Robert J Williams, Juan A. Abin-Carriquiry
Jun 19, 2017
The ubiquitous flavonoid quercetin is broadly recognized for showing diverse biological and health-promoting effects, such as anti-cancer, anti-inflammatory and cytoprotective activities. The therapeutic potential of quercetin...
Effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose-insulin dynamics in young adult horses.
The rK39 Antigen from an Iranian Strain of Leishmania infantum
Bibi Razieh Hosseini Farash, Mehdi Mohebali, Bahram Kazemi, Homa Hajjaran, Abdolmajid Fata, Reza Raoofian, Behnaz Akhoundi, Majid Mojarrad, Pietro Mastroeni, Mohammad Kazem Sharifi-Yazdi, Mohammad Hossein Tanipour
Mar 31, 2020
BACKGROUND: Visceral leishmaniasis (VL) is the most severe form of leishmaniasis in Iran with high mortality rates in the case of inaccurate diagnosis and treatment. This study aimed to prepare and evaluate a new rk39...
Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I.
BACKGROUND: M184V/I cause high-level lamivudine (3TC) and emtricitabine (FTC) resistance and increased tenofovir disoproxil fumarate (TDF) susceptibility. Nonetheless, 3TC and FTC (collectively referred to as XTC) appear to...
HIV antiretroviral compensatory mutation Drug Resistance Lamivudine Anti-HIV Agents CD4 Lymphocyte Count Drug Resistance Viral Drug Therapy Combination Emtricitabine HIV Infections HIV Reverse Transcriptase HIV-1 Humans Lamivudine Mutation Randomized Controlled Trials as Topic Reverse Transcriptase Inhibitors Tenofovir Treatment Failure Viral Load
Results from the first English stool bank using faecal microbiota transplant as a medicinal product for the treatment of Clostridioides difficile infection.
VL McCune, MN Quraishi, S Manzoor, CE Moran, K Banavathi, H Steed, DCO Massey, GR Trafford, TH Iqbal, PM Hawkey
May 18, 2020
BACKGROUND: Faecal Microbiota Transplant (FMT) has improved outcomes for the treatment of Clostridioides difficile infection (CDI) compared to antibiotic therapy. FMT is classified as a medicinal product in the United Kingdom...
Earlier Physical Therapy Input is Associated with a Reduced Length of Hospital Stay and Reduced Care Needs on Discharge in Frail Older Inpatients
PJ Hartley, VL Keevil, L Alushi, RL Charles, EB Conroy, PM Costello, B Dixon, AM Dolinska-Grzybek, D Vajda, R Romero-Ortuno
May 23, 2017
$\textbf{Background and Purpose}$:
Pressures on hospital bed occupancy in the English National Health Service (NHS) have focused attention on enhanced service delivery models and methods by which physical therapists might...
Structural evidence of quercetin multi-target bioactivity
Diego Carvalho, Margot Paulino, Fabio Polticelli, Florencia Arredondo, Robert J Williams, Juan A. Abin-Carriquiry
Jun 19, 2017
The ubiquitous flavonoid quercetin is broadly recognized for showing diverse biological and health-promoting effects, such as anti-cancer, anti-inflammatory and cytoprotective activities. The therapeutic potential of quercetin...
Cross-sectional associations between different measures of obesity and muscle strength in men and women in a British cohort study.
Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3.
Nigel Vicker, Helen V Bailey, Joanna M Day, Mary F Mahon, Andrew Smith, Helena J Tutill, Atul Purohit, Barry VL Potter
Dec 15, 2021
17β-Hydroxysteroid dehydrogenase type 3 (17β-HSD3) is expressed at high levels in testes and seminal vesicles; it is also present in prostate tissue and involved in gonadal and non-gonadal testosterone biosynthesis. The enzyme...
X-ray crystallography chiral chromatography dehydrogenase homology modelling prostate cancer Synthesis 17-Hydroxysteroid Dehydrogenases Benzylamines Cell Line Tumor Crystallography X-Ray Enzyme Inhibitors Humans Inhibitory Concentration 50 Male Molecular Docking Simulation Prostate Prostatic Neoplasms Structure-Activity Relationship Testosterone
An observational study in an urban Ugandan clinic comparing virological outcomes of patients switched from first-line antiretroviral regimens to second-line regimens containing ritonavir-boosted atazanavir or ritonavir-boosted lopinavir.
Eva Agnes Odongpiny Laker, Maria Sarah Nabaggala, Arvind Kaimal, Damalie Nalwanga, Barbara Castelnuovo, Abdu Musubire, Agnes Kiragga, Mohammed Lamorde, Rosalind Parkes- Ratanshi
Sep 06, 2019
BACKGROUND: The World Health Organisation approved boosted atazanavir as a preferred second line protease inhibitor in 2010. This is as an alternative to the current boosted lopinavir. Atazanavir has a lower genetic barrier than...
Quantal Ca2+ release mediated by very few IP3 receptors that rapidly inactivate allows graded responses to IP3
Colin Taylor, Andrew M Riley, Genevieve Dupont, Taufiq Rahman, Barry VL Potter, Ana M Rossi
Apr 14, 2022
Ca(2+) signaling IP(3) receptor IP(3) receptor antagonist Endoplasmic Reticulum intracellular Ca(2+) stores partial agonist quantal Ca(2+) release receptor inactivation Animals Calcium Calcium Signaling Chickens Drug Partial Agonism Endoplasmic Reticulum HEK293 Cells Humans Inositol 1 4 5-Trisphosphate Inositol 1 4 5-Trisphosphate Receptors inositol phosphates Time Factors
Development and validation of a dynamic 48-hour in-hospital mortality risk stratification for COVID-19 in a UK teaching hospital
Objectives To develop a disease stratification model for COVID-19 that updates according to changes in a patient’s condition while in hospital to facilitate patient management and...
M Wiegand, SL Cowan, CS Waddington, DJ Halsall, VL Keevil, BDM Tom, V Taylor, E Gkrania-Klotsas, J Preller, RJB Goudie
Sep 08, 2022
Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*.
João PM António, Joana Inês Carvalho, Ana S André, Joana NR Dias, Sandra I Aguiar, Hélio Faustino, Ricardo MRM Lopes, Luis F Veiros, Gonçalo JL Bernardes, Frederico A da Silva, Pedro MP Gois
Oct 08, 2021
Antibody-drug conjugates (ADCs) are a new class of therapeutics that combine the lethality of potent cytotoxic drugs with the targeting ability of antibodies to selectively deliver drugs to cancer cells. In this study we show...
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