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Results: 298
Perceptual Learning, Long-Range Horizontal Connections And Top-Down Influences In Primary Visual Cortex
Valentin Piëch
Jan 01, 0001
The earliest cortical stage of visual processing, the primary visual cortex, has long been seen as a static preprocessor that finds local edges and their orientation like a linear filter bank, and passes this information on to...
Published by: Rockefeller University
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease
Siddhartha Jaiswal, Pradeep Natarajan, Alexander J Silver, Christopher J Gibson, Alexander G Bick, Eugenia Shvartz, Marie McConkey, Namrata Gupta, Stacey Gabriel, Diego Ardissino, Usman Baber, Roxana Mehran, Valentin Fuster, John Danesh, Philippe Frossard, Danish Saleheen, Olle Melander, Galina K Sukhova, Donna Neuberg, Peter Libby, Sekar Kathiresan, Benjamin L Ebert
Nov 28, 2017
The Gamification of Code
Teaching an introductory web design course is already a blended environment. Students meet face-to-face, yet have access to a myriad of online resources, YouTube videos, blogs, and forums to support their learning. However, the...
Published by: IGI Global Scientific Publishing
Assessing international alcohol consumption patterns during isolation from the COVID-19 pandemic using an online survey
Recovering World-Welcoming Words
This article presents a theological–literary response to a concern in contemporary theory with heeding and articulating the speech of nonhuman things. Drawing from Rowan Williams’ metaphysics of poetic addition, I argue...
Valentin Gerlier
Jul 07, 2021
Assessing international alcohol consumption patterns during isolation from the COVID-19 pandemic using an online survey
Objectives: The COVID-19 pandemic has required drastic safety measures to control virus spread, including an extended self-isolation period. Stressful situations increase alcohol craving and consumption in alcohol use disorder...
Fine-scale computations for adaptive processing in the human brain
Elisa Zamboni, Valentin G Kemper, Nuno Reis Goncalves, Ke Jia, Vasilis M Karlaftis, Samuel J Bell, Joseph Giorgio, Reuben Rideaux, Rainer Goebel, Zoe Kourtzi
Nov 26, 2020
Adapting to the environment statistics by reducing brain responses to repetitive sensory information is key for efficient information processing. Yet, the fine-scale computations that support this adaptive processing in the...
Update on Streptococcus suis Research and Prevention in the Era of Antimicrobial Restriction
Mariela Segura, Virginia Aragon, Susan L Brockmeier, Connie Gebhart, Astrid de Greeff, Anusak Kerdsin, Mark A O'Dea, Masatoshi Okura, Mariette Saléry, Constance Schultsz, Peter Valentin-Weigand, Lucy A Weinert, Jerry M Wells, Marcelo Gottschalk
Aug 10, 2020
Streptococcus suis is a swine pathogen and a zoonotic agent afflicting people in close contact with infected pigs or pork meat. Sporadic cases of human infections have been reported worldwide. In addition, S. suis outbreaks...
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Petar Scepanovic, Flavia Hodel, Stanislas Mondot, Valentin Partula, Allyson Byrd, Christian Hammer, Cécile Alanio, Jacob Bergstedt, Etienne Patin, Mathilde Touvier, Olivier Lantz, Matthew L Albert, Darragh Duffy, Lluis Quintana-Murci, Jacques Fellay, Milieu Intérieur Consortium
Feb 07, 2020
BACKGROUND: The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu...
A protocol for ultra-high field laminar fMRI in the human brain.
Ke Jia, Elisa Zamboni, Catarina Rua, Nuno Reis Goncalves, Valentin Kemper, Adrian Ka Tsun Ng, Christopher T Rodgers, Guy Williams, Rainer Goebel, Zoe Kourtzi
Feb 26, 2021
Ultra-High-Field Neuroimaging Reveals Fine-Scale Processing for 3D Perception.
Adrian KT Ng, Ke Jia, Nuno R Goncalves, Elisa Zamboni, Valentin G Kemper, Rainer Goebel, Andrew E Welchman, Zoe Kourtzi
Jul 09, 2021
Ferroelectric Orthorhombic ZrO2 Thin Films Achieved Through Nanosecond Laser Annealing.
Anna PS Crema, Marian C Istrate, Alexandre Silva, Veniero Lenzi, Leonardo Domingues, Megan O Hill, Valentin S Teodorescu, Corneliu Ghica, Maria JM Gomes, Mario Pereira, Luís Marques, Judith L Macmanus-Driscoll, José PB Silva
Mar 23, 2023
A new approach for the stabilization of the ferroelectric orthorhombic ZrO2 films is demonstrated through nanosecond laser annealing (NLA) of as-deposited Si/SiOx /W(14 nm)/ZrO2 (8 nm)/W(22 nm), grown by ion beam sputtering at...
Recurrent Processing Drives Perceptual Plasticity.
Ke Jia, Elisa Zamboni, Valentin Kemper, Catarina Rua, Nuno Reis Goncalves, Adrian Ka Tsun Ng, Christopher T Rodgers, Guy Williams, Rainer Goebel, Zoe Kourtzi
Aug 10, 2020
Learning and experience are critical for translating ambiguous sensory information from our environments to perceptual decisions. Yet evidence on how training molds the adult human brain remains controversial, as fMRI at...
experience-dependent plasticity layer-to-layer functional connectivity learning perceptual decisions ultra-high-field brain imaging Visual Cortex Adult Female Humans Magnetic Resonance Imaging Male Neuronal Plasticity Orientation Spatial Photic Stimulation Spatial Learning Visual Cortex Visual Perception Young Adult
Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1.
Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Christina Hetzmannseder, Gertrude Zisser, Carolin Sailer, Vasileios Kargas, Mathias Loibl, Magdalena Gerhalter, Lisa Kofler, Alan J Warren, Florian Stengel, David Haselbach, Helmut Bergler
Sep 23, 2022
The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling maturation factor Rlp24 from pre-60S particles shortly after...
A Decaheme Cytochrome as a Molecular Electron Conduit in Dye-Sensitized Photoanodes.
Ee Taek Hwang, Khizar Sheikh, Katherine L Orchard, Daisuke Hojo, Valentin Radu, Chong-Yong Lee, Emma Ainsworth, Colin Lockwood, Manuela A Gross, Tadafumi Adschiri, Erwin Reisner, Julea N Butt, Lars JC Jeuken
May 18, 2015
CyanoGate
Ravendran Vasudevan, Grant AR Gale, Alejandra A Schiavon, Anton Puzorjov, John Malin, Michael D Gillespie, Konstantinos Vavitsas, Valentin Zulkower, Baojun Wang, Christopher J Howe, David J Lea-Smith, Alistair J McCormick
Mar 14, 2019
Recent advances in synthetic biology research have been underpinned by an exponential increase in available genomic information and a proliferation of advanced DNA assembly tools. The adoption of plasmid vector assembly...
Cysteine oxidation and disulfide formation in the ribosomal exit tunnel.
Linda Schulte, Jiafei Mao, Julian Reitz, Sridhar Sreeramulu, Denis Kudlinzki, Victor-Valentin Hodirnau, Jakob Meier-Credo, Krishna Saxena, Florian Buhr, Julian D Langer, Martin Blackledge, Achilleas S Frangakis, Clemens Glaubitz, Harald Schwalbe
Nov 09, 2020
HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting
Patrick Neubert, Andrea Weichselbaum, Carmen Reitinger, Valentin Schatz, Agnes Schröder, John R Ferdinand, Michaela Simon, Anna-Lorena Bär, Christoph Brochhausen, Roman G Gerlach, Stefan Tomiuk, Karin Hammer, Stefan Wagner, Ger van Zandbergen, Katrina J Binger, Dominik N Müller, Kento Kitada, Menna R Clatworthy, Christian Kurts, Jens Titze, Zeinab Abdullah, Jonathan Jantsch
Apr 17, 2019
Autophagy cell-autonomous immunity macrophage salt sodium Animals Autophagosomes Autophagy Escherichia coli Homeodomain Proteins Hydrogen-Ion Concentration Hypoxia-Inducible Factor 1 alpha Subunit Inflammation Lysosomes MACROPHAGES Mannitol Mice Microscopy Electron Transmission Nitric Oxide Synthase Type II Oligonucleotide Array Sequence Analysis Osmotic Pressure Proto-Oncogene Proteins c-akt Reactive Oxygen Species sodium TOR Serine-Threonine Kinases Transcription Factors
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jul 30, 2021
Background
Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the...
genetic variation cardiac hypertrophy complex disease ribosome biogenesis ribosome profiling ribosomopathy Translational efficiency Spontaneously hypertensive rats (SHR) HXB/BXH rat recombinant inbred panel trans QTL mapping
Published by: Genome biology
Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting
P Natarajan, R Young, NO Stitziel, S Padmanabhan, U Baber, R Mehran, S Sartori, V Fuster, DF Reilly, A Butterworth, DJ Rader, I Ford, N Sattar, S Kathiresan
Oct 30, 2017
Background: Relative risk reduction with statin therapy has been consistent across nearly all subgroups studied to date. However, in analyses of 2 randomized controlled primary prevention trials (ASCOT [Anglo-Scandinavian...
Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Polymorphism Genetic Primary Prevention Vascular Calcification Adolescent Adult Aged Aged 80 and over Atherosclerosis Cohort Studies Cost of Illness Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Male Middle Aged Multifactorial Inheritance Primary Prevention Risk Factors Young Adult
Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion.
Valentin Gorboulev, Annette Schürmann, Volker Vallon, Helmut Kipp, Alexander Jaschke, Dirk Klessen, Alexandra Friedrich, Stephan Scherneck, Timo Rieg, Robyn Cunard, Maike Veyhl-Wichmann, Aruna Srinivasan, Daniela Balen, Davorka Breljak, Rexhep Rexhepaj, Helen E Parker, Fiona M Gribble, Frank Reimann, Florian Lang, Stefan Wiese, Ivan Sabolic, Michael Sendtner, Hermann Koepsell
Jan 31, 2020
To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose...
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jun 28, 2021
A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.
Franziska Witte, Jorge Ruiz-Orera, Camilla Ciolli Mattioli, Susanne Blachut, Eleonora Adami, Jana Felicitas Schulz, Valentin Schneider-Lunitz, Oliver Hummel, Giannino Patone, Michael Benedikt Mücke, Jan Šilhavý, Matthias Heinig, Leonardo Bottolo, Daniel Sanchis, Martin Vingron, Marina Chekulaeva, Michal Pravenec, Norbert Hubner, Sebastiaan van Heesch
Jul 02, 2021
BACKGROUND: Little is known about the impact of trans-acting genetic variation on the rates with which proteins are synthesized by ribosomes. Here, we investigate the influence of such distant genetic loci on the efficiency of...
cardiac hypertrophy complex disease genetic variation HXB/BXH rat recombinant inbred panel ribosome biogenesis ribosome profiling ribosomopathy Spontaneously hypertensive rats (SHR) Translational efficiency trans QTL mapping Animals Cardiomegaly Gene Expression Profiling Gene Expression Regulation genetic variation Male Mice Mice Inbred C57BL Mice Knockout Myocardium Organelle Biogenesis Peptide Chain Initiation Translational Quantitative Trait Loci RNA Messenger RNA Small Nucleolar Rats Rats Inbred SHR Rats Transgenic Ribosomal Proteins Ribosomes Saccharomyces cerevisiae Sarcomeres
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