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Results: 78835
Dietary energy density in relation to subsequent changes of weight and waist circumference in European men and women.
Huaidong Du, Daphne L van der A, Vanessa Ginder, Susan A Jebb, Nita G Forouhi, Nicholas J Wareham, Jytte Halkjaer, Anne Tjønneland, Kim Overvad, Marianne Uhre Jakobsen, Brian Buijsse, Annika Steffen, Domenico Palli, Giovanna Masala, Wim HM Saris, Thorkild IA Sørensen, Edith JM Feskens
Mar 21, 2018
BACKGROUND: Experimental studies show that a reduction in dietary energy density (ED) is associated with reduced energy intake and body weight. However, few observational studies have investigated the role of ED on long-term...
A re-annotation pipeline for Illumina BeadArrays
Nuno L Barbosa-Morais, Mark J Dunning, Shamith A Samarajiwa, Jeremy FJ Darot, Matthew E Ritchie, Andy G Lynch, Simon Tavaré
Feb 13, 2020
Illumina BeadArrays are among the most popular and reliable platforms for gene expression profiling. However, little external scrutiny has been given to the design, selection and annotation of BeadArray probes, which is a...
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
João Conde, Ruth A Pumroy, Charlotte Baker, Tiago Rodrigues, Ana Guerreiro, Bárbara B Sousa, Marta C Marques, Bernardo P de Almeida, Sohyon Lee, Elvira P Leites, Daniel Picard, Amrita Samanta, Sandra H Vaz, Florian Sieglitz, Maike Langini, Marc Remke, Rafael Roque, Tobias Weiss, Michael Weller, Yuhang Liu, Seungil Han, Francisco Corzana, Vanessa A Morais, Cláudia C Faria, Tânia Carvalho, Panagis Filippakopoulos, Berend Snijder, Nuno L Barbosa-Morais, Vera Y Moiseenkova-Bell, Gonçalo JL Bernardes
Apr 20, 2021
The use of computational tools to identify biological targets of natural products with anticancer properties and unknown modes of action is gaining momentum. We employed self-organizing maps to deconvolute the phenotypic effects...
Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L Seabra, Miguel Constância, Mariana P Monteiro
Aug 16, 2021
BACKGROUND: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be...
A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition.
Most solid tumors contain aneuploid cells, indicating that the mitotic checkpoint is permissive to the proliferation of chromosomally aberrant cells. However, mutated or altered expression of mitotic checkpoint genes accounts...
The Structural and Functional Analysis of a Voltage-Dependent Potassium Channel
Vanessa Ruta
Jan 01, 0001
Voltage-dependent ion channels are finely tuned to open and allow ion conduction in response to changes in the membrane voltage, a function that lies at the heart of nerve impulse generation and propagation. These channels...
voltage-dependent ion channels voltage-dependent gating KvAP channels potassium channel Life Sciences
Published by: Rockefeller University
A mycotic aneurysm related to Salmonella Rissen infection
BACKGROUND: Salmonella species commonly causes infection in humans and on occasion leads to serious complications, such as mycotic aneurysms. Here, we present the first case reported of a patient with a mycotic aneurysm likely...
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.
João Conde, Ruth A Pumroy, Charlotte Baker, Tiago Rodrigues, Ana Guerreiro, Bárbara B Sousa, Marta C Marques, Bernardo P de Almeida, Sohyon Lee, Elvira P Leites, Daniel Picard, Amrita Samanta, Sandra H Vaz, Florian Sieglitz, Maike Langini, Marc Remke, Rafael Roque, Tobias Weiss, Michael Weller, Yuhang Liu, Seungil Han, Francisco Corzana, Vanessa A Morais, Cláudia C Faria, Tânia Carvalho, Panagis Filippakopoulos, Berend Snijder, Nuno L Barbosa-Morais, Vera Y Moiseenkova-Bell, Gonçalo J L Bernardes
Jul 07, 2021
The use of computational tools to identify biological targets of natural products with anticancer properties and unknown modes of action is gaining momentum. We employed self-organizing maps to deconvolute the phenotypic effects...
Published by: ACS central science
Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L. Seabra, Miguel Constância, Mariana P. Monteiro
Jul 28, 2021
Background: Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be...
Adipose Tissue Epigenetic Profile in Obesity-Related Dysglycemia - A Systematic Review.
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L Seabra, Miguel Constância, Mariana P Monteiro
Aug 26, 2021
Background
Obesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be...
obesity DNA Methylation Insulin Resistance Adipose Tissue Type 2 diabetes Histone modifications long non-coding RNAs Dysglycemia
Published by: Frontiers in endocrinology
A mycotic aneurysm related to Salmonella Rissen infection
Abstract: Background: Salmonella species commonly causes infection in humans and on occasion leads to serious complications, such as mycotic aneurysms. Here, we present the first case reported of a patient with a mycotic...
A mycotic aneurysm related to Salmonella Rissen infection
BACKGROUND:Salmonella species commonly causes infection in humans and on occasion leads to serious complications, such as mycotic aneurysms. Here, we present the first case reported of a patient with a mycotic aneurysm likely...
Published by: BMC infectious diseases
Promoting Social Relationships Using a Couch Cooperative Video Game
Manuel Garcia, Vanessa Rull, Shirley Gunawardana, Dylan Bias, Roseanne Chua, Jairus Cruz, Ma.Corazon Raguro, Maria Perez
Jan 01, 2022
Social relationships are a fundamental aspect of human existence. Unsurprisingly, policymakers are incessantly devising strategies that accentuate the benefits of social relationships and diminish the risks of social isolation....
Published by: IGI Global Scientific Publishing
Qualitative process evaluation from a complex systems perspective
Background: Public health evaluation methods have been criticized for being overly reductionist and failing to generate suitable evidence for public health decision-making. A “complex systems approach” has been advocated to...
What is the nature of peer interactions in children with language disorders? A qualitative study of parent and practitioner views
Background & Aims: Children with Language Disorders (LDs) can exhibit increased levels of social withdrawal, aggression and problems managing social conflicts. The reasons underlying this pattern of social interaction...
Achieving robustness to aleatoric uncertainty with heteroscedastic Bayesian optimisation
Ryan-Rhys Griffiths, Alexander A Aldrick, Miguel Garcia-Ortegon, Vidhi Lalchand, Alpha A Lee
Nov 23, 2021
Abstract: Bayesian optimisation is a sample-efficient search methodology that holds great promise for accelerating drug and materials discovery programs. A frequently-overlooked modelling consideration in Bayesian optimisation...
Qualitative process evaluation from a complex systems perspective
BACKGROUND: Public health evaluation methods have been criticized for being overly reductionist and failing to generate suitable evidence for public health decision-making. A "complex systems approach" has been advocated to...
An engineered GH1 β-glucosidase displays enhanced glucose tolerance and increased sugar release from lignocellulosic materials.
Clelton A Santos, Mariana AB Morais, Oliver M Terrett, Jan J Lyczakowski, Letícia M Zanphorlin, Jaire A Ferreira-Filho, Celisa CC Tonoli, Mario T Murakami, Paul Dupree, Anete P Souza
May 27, 2019
β-glucosidases play a critical role among the enzymes in enzymatic cocktails designed for plant biomass deconstruction. By catalysing the breakdown of β-1, 4-glycosidic linkages, β-glucosidases produce free fermentable glucose...
A consensus prognostic gene expression classifier for ER positive breast cancer.
Andrew E Teschendorff, Ali Naderi, Nuno L Barbosa-Morais, Sarah E Pinder, Ian O Ellis, Sam Aparicio, James D Brenton, Carlos Caldas
Jan 03, 2018
BACKGROUND: A consensus prognostic gene expression classifier is still elusive in heterogeneous diseases such as breast cancer. RESULTS: Here we perform a combined analysis of three major breast cancer microarray data sets to...
A Serious Game for Emotion Regulation in Adolescents
Gloria Mittmann, Adam Barnard, Sonja Zehetmayer, Simon Wimmer, Vanessa Zehetner, Sylvia Doerfler, Kate Woodcock, Beate Schrank
Jan 01, 2024
Early adolescence is a major time for friendship development, and interpersonal emotion regulation (iER) is a vital skill for social interactions. Serious games are an exciting way to engage young people with psychoeducational...
Published by: IGI Global Scientific Publishing
Depression amongst interns working in a tertiary care teaching Hospital in Maharashtra
Background: Internship is a crucial stage of medical school regarding student stress which can affect the patient care negatively. Retrieving knowledge about presence of depression is therefore important in itself and if found...
Published by: IJHS Medical Association
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