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Results: 138
Correlation-Adjusted Regression Survival Scores for High-Dimensional Variable Selection
biomarker discovery Breast Cancer multigene signature personalized medicine prostate cancer survival modeling Aged Aged 80 and over Biomarkers Tumor Breast Neoplasms Computer Simulation Female Genetic Markers Humans Male Middle Aged Proportional Hazards Models Prostatic Neoplasms Regression Analysis Survival Analysis Watchful Waiting
Imminent dystopia? Media coverage of algorithmic surveillance at Berlin-Südkreuz
Anna Verena Eireiner
Apr 02, 2020
Facial-recognition software continues to create heated controversy, as illustrated by a year-long pilot run at the Berlin-Südkreuz train station. The test run at one of Berlin’s main arteries was a catalyst for media attention...
Inferring Causal Relationships Between Risk Factors and Outcomes from Genome-Wide Association Study Data.
An observational correlation between a suspected risk factor and an outcome does not necessarily imply that interventions on levels of the risk factor will have a causal impact on the outcome (correlation is not causation). If...
Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization.
Modern high-throughput experiments provide a rich resource to investigate causal determinants of disease risk. Mendelian randomization (MR) is the use of genetic variants as instrumental variables to infer the causal effect of a...
Group-based parent training programmes for improving parental psychosocial health.
BACKGROUND: Parental psychosocial health can have a significant effect on the parent-child relationship, with consequences for the later psychological health of the child. Parenting programmes have been shown to have an impact...
Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization.
Modern high-throughput experiments provide a rich resource to investigate causal determinants of disease risk. Mendelian randomization (MR) is the use of genetic variants as instrumental variables to infer the causal effect of a...
Published by: Nature Communications
Impact of Genetically Predicted Red Blood Cell Traits on Venous Thromboembolism
Background Red blood cell (RBC) transfusion and erythropoiesis-stimulating agent administration are cornerstones of clinical practice, yet concerns exist as to potential increased risk of thrombotic events. This study aims to...
High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease.
Verena Zuber, Dipender Gill, Mika Ala-Korpela, Claudia Langenberg, Adam Butterworth, Leonardo Bottolo, Stephen Burgess
Sep 21, 2020
BACKGROUND: Genetic variants can be used to prioritize risk factors as potential therapeutic targets via Mendelian randomization (MR). An agnostic statistical framework using Bayesian model averaging (MR-BMA) can disentangle the...
The relationship between pain and suicidal vulnerability in adolescence
Verena Hinze, Catherine Crane, Tamsin Ford, Ruta Buivydaite, Lin Qiu, Bergljot Gjelsvik
Dec 16, 2019
Modal-based estimation via heterogeneity-penalized weighting
BACKGROUND: A robust method for Mendelian randomization does not require all genetic variants to be valid instruments to give consistent estimates of a causal parameter. Several such methods have been developed, including a...
Reversal of murine alcoholic steatohepatitis by pepducin-based functional blockade of interleukin-8 receptors.
Verena Wieser, Timon E Adolph, Barbara Enrich, Athan Kuliopulos, Arthur Kaser, Herbert Tilg, Nicole C Kaneider
Dec 08, 2015
ALCOHOLIC LIVER DISEASE IMMUNE-MEDIATED LIVER DAMAGE INTERLEUKIN 8 Leukocytes Alanine Transaminase Animals Aspartate Aminotransferases Caspase 1 Chemokine CXCL1 Chemotaxis Fatty Liver Alcoholic Female Hep G2 Cells Hepatitis Hepatocytes Humans Interleukin-1beta Lipid Metabolism Lipopeptides Mice Mice Inbred C57BL Neutrophils Peroxidase Receptors Interleukin-8A Receptors Interleukin-8B Signal Transduction Survival Rate Transcription Genetic Triglycerides Tumor Necrosis Factor-alpha Weight Loss
Willingness to donate genomic and other medical data
Torsten H. Voigt, Verena Holtz, Emilia Niemiec, Heidi C. Howard, Anna Middleton, Barbara Prainsack
Jul 24, 2020
Abstract: This paper reports findings from Germany-based participants in the “Your DNA, Your Say” study, a collaborative effort among researchers in more than 20 countries across the world to explore public attitudes, values and...
The immunopathology of ANCA-associated vasculitis.
The small-vessel vasculitides are a group of disorders characterised by variable patterns of small blood vessel inflammation producing a markedly heterogeneous clinical phenotype. While any vessel in any organ may be involved...
Service use and costs in adolescents with pain and suicidality
Verena Hinze, Tamsin Ford, Bergljot Gjelsvik, Sarah Byford, Andrea Cipriani, Jesus Montero-Marin, Poushali Ganguli
Mar 02, 2023
BACKGROUND: Persistent/recurrent pain for more than three months and suicidality (suicide and self-harm related thoughts and behaviours) are serious and co-occurring health problems in adolescence, underscoring the need for...
Clinical indicators for bacterial co-infection in Ghanaian children with P. falciparum infection.
Maja Verena Nielsen, Solomon Amemasor, Alex Agyekum, Wibke Loag, Florian Marks, Nimako Sarpong, Denise Dekker, Yaw Adu-Sarkodie, Jürgen May
Feb 19, 2019
Differentiation of infectious causes in severely ill children is essential but challenging in sub- Saharan Africa. The aim of the study was to determine clinical indicators that are able to identify bacterial co-infections in P....
Adolescent Anthropometry Bacteremia Child Child Preschool Coinfection Cough Dehydration Ghana Humans Malaria Falciparum Odds Ratio Predictive Value of Tests prevalence Regression Analysis Rural Population Salmonella Infections Sensitivity and Specificity Socioeconomic Factors Splenomegaly Streptococcal Infections
Screw tightness and stripping rates vary between biomechanical researchers and practicing orthopaedic surgeons
James Fletcher, Verena Neumann, Lisa Wenzel, Boyko Gueorguiev-Rüegg, R. Richards, H S Gill, Michael Whitehouse, Ezio Preatoni
Oct 26, 2021
Background
Screws are the most frequently inserted orthopaedic implants. Biomechanical, laboratory-based studies are used to provide a controlled environment to investigate revolutionary and evolutionary improvements in...
Screws are the most frequently inserted orthopaedic implants. Biomechanical, laboratory-based studies are used to provide a controlled environment to investigate revolutionary and evolutionary improvements in...
Combining evidence from Mendelian randomization and colocalization
Verena Zuber, Nastasiya F Grinberg, Dipender Gill, Ichcha Manipur, Eric AW Slob, Ashish Patel, Chris Wallace, Stephen Burgess
May 24, 2022
Mendelian randomization and colocalization are two statistical approaches that can be applied to summarized data from genome-wide association studies (GWASs) to understand relationships between traits and diseases. However...
Breaking the Screen
Verena Biener, Daniel Schneider, Travis Gesslein, Alexander Otte, Bastian Kuth, Per Ola Kristensson, Eyal Ofek, Michel Pahud, Jens Grubert
Sep 23, 2020
Virtual Reality (VR) has the potential to transform knowledge work. One advantage of VR knowledge work is that it allows extending 2D displays into the third dimension, enabling new operations, such as selecting overlapping...
Screw tightness and stripping rates vary between biomechanical researchers and practicing orthopaedic surgeons
James Fletcher, Verena Neumann, Lisa Wenzel, Boyko Gueorguiev-Rüegg, R. Richards, H S Gill, Michael Whitehouse, Ezio Preatoni
Oct 26, 2021
Background
Screws are the most frequently inserted orthopaedic implants. Biomechanical, laboratory-based studies are used to provide a controlled environment to investigate revolutionary and evolutionary improvements in...
Screws are the most frequently inserted orthopaedic implants. Biomechanical, laboratory-based studies are used to provide a controlled environment to investigate revolutionary and evolutionary improvements in...
One Health Approaches to Trace Mycobacterium leprae ’s Zoonotic Potential Through Time
Christian Urban, Alette A. Blom, Saskia Pfrengle, Kathleen Walker-Meikle, Anne C. Stone, Sarah A. Inskip, Verena J. Schuenemann
Nov 04, 2021
Hansen’s disease (leprosy), mainly caused by infection with Mycobacterium leprae, has accompanied humanity for thousands of years. Although currently rare in Europe, there are over 200,000 new infections annually in South East...
MethylCal
Eguzkine Ochoa, Verena Zuber, Nora Fernandez-Jimenez, Jose Ramon Bilbao, Graeme R Clark, Eamonn R Maher, Leonardo Bottolo
May 03, 2019
Bisulfite amplicon sequencing has become the primary choice for single-base methylation quantification of multiple targets in parallel. The main limitation of this technology is a preferential amplification of an allele and...
Variations in non-locking screw insertion conditions generate unpredictable changes to achieved fixation tightness and stripping rates
James Fletcher, Verena Neumann, Lisa Wenzel, Boyko Gueorguiev, R. Geoff Richards, Richie Gill, Michael R. Whitehouse, Ezio Preatoni
Dec 01, 2020
Background Screws are the most commonly inserted orthopaedic implants. However, several variables related to screw insertion and tightening have not been evaluated. This study aimed firstly to assess the effect of insertion...
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