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Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length.
Paddy C Dempsey, Crispin Musicha, Alex V Rowlands, Melanie Davies, Kamlesh Khunti, Cameron Razieh, Iain Timmins, Francesco Zaccardi, Veryan Codd, Christopher P Nelson, Tom Yates, Nilesh J Samani
Apr 20, 2022
Walking pace is a simple and functional form of movement and a strong predictor of health status, but the nature of its association with leucocyte telomere length (LTL) is unclear. Here we investigate whether walking pace is...
Telomere Length and Risk of Incident Fracture and Arthroplasty
Elizabeth M Curtis, Veryan Codd, Christopher Nelson, Stefania D'Angelo, Qingning Wang, Elias Allara, Stephen Kaptoge, Paul M Matthews, Jonathan H Tobias, John Danesh, Cyrus Cooper, Nilesh J Samani, Nicholas C Harvey
Sep 14, 2022
aging EPIDEMIOLOGY Leucocyte telomere length Osteoarthritis Osteoporosis Female Male Humans Middle Aged Hand Strength Arthroplasty Replacement Hip Biological Specimen Banks Arthroplasty Replacement Knee Fractures Bone Bone Density Telomere United Kingdom Risk Factors Osteoporotic Fractures Hip Fractures
Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length
Paddy C. Dempsey, Crispin Musicha, Alex V. Rowlands, Melanie Davies, Kamlesh Khunti, Cameron Razieh, Iain Timmins, Francesco Zaccardi, Veryan Codd, Christopher P. Nelson, Tom Yates, Nilesh J. Samani
May 19, 2022
Abstract: Walking pace is a simple and functional form of movement and a strong predictor of health status, but the nature of its association with leucocyte telomere length (LTL) is unclear. Here we investigate whether walking...
Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length.
Paddy C Dempsey, Crispin Musicha, Alex V Rowlands, Melanie Davies, Kamlesh Khunti, Cameron Razieh, Iain Timmins, Francesco Zaccardi, Veryan Codd, Christopher P Nelson, Tom Yates, Nilesh J Samani
May 22, 2022
Walking pace is a simple and functional form of movement and a strong predictor of health status, but the nature of its association with leucocyte telomere length (LTL) is unclear. Here we investigate whether walking pace is...
Investigation of a UK biobank cohort reveals causal associations of self-reported walking pace with telomere length
Paddy C. Dempsey, Crispin Musicha, Alex V. Rowlands, Melanie Davies, Kamlesh Khunti, Cameron Razieh, Iain Timmins, Francesco Zaccardi, Veryan Codd, Christopher P. Nelson, Tom Yates, Nilesh J. Samani
May 20, 2022
Abstract: Walking pace is a simple and functional form of movement and a strong predictor of health status, but the nature of its association with leucocyte telomere length (LTL) is unclear. Here we investigate whether walking...
Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes
Qingning Wang, Veryan Codd, Zahra Raisi-Estabragh, Crispin Musicha, Vasiliki Bountziouka, Stephen Kaptoge, Elias Allara, Emanuele Di Angelantonio, Adam S Butterworth, Angela M Wood, John R Thompson, Steffen E Petersen, Nicholas C Harvey, John N Danesh, Nilesh J Samani, Christopher P Nelson
Aug 24, 2021
Association of shorter leucocyte telomere length with risk of frailty.
Vasiliki Bountziouka, Christopher P Nelson, Veryan Codd, Qingning Wang, Crispin Musicha, Elias Allara, Stephen Kaptoge, Emanuele Di Angelantonio, Adam S Butterworth, John R Thompson, Elizabeth M Curtis, Angela M Wood, John N Danesh, Nicholas C Harvey, Cyrus Cooper, Nilesh J Samani
Jun 09, 2022
Reproducibility of telomere length assessment
Carmen M Martin-Ruiz, Duncan Baird, Laureline Roger, Petra Boukamp, Damir Krunic, Richard Cawthon, Martin M Dokter, Pim van der Harst, Sofie Bekaert, Tim de Meyer, Goran Roos, Ulrika Svenson, Veryan Codd, Nilesh J Samani, Liane McGlynn, Paul G Shiels, Karen A Pooley, Alison M Dunning, Rachel Cooper, Andrew Wong, Andrew Kingston, Thomas von Zglinicki
Oct 07, 2015
Polygenic basis and biomedical consequences of telomere length variation
Veryan Codd, Qingning Wang, Elias Allara, Crispin Musicha, Stephen Kaptoge, Svetlana Stoma, Tao Jiang, Stephen E. Hamby, Peter S. Braund, Vasiliki Bountziouka, Charley A. Budgeon, Matthew Denniff, Chloe Swinfield, Manolo Papakonstantinou, Shilpi Sheth, Dominika E. Nanus, Sophie C. Warner, Minxian Wang, Amit V. Khera, James Eales, Willem H. Ouwehand, John R. Thompson, Emanuele Di Angelantonio, Angela M. Wood, Adam S. Butterworth, John N. Danesh, Christopher P. Nelson, Nilesh J. Samani
Oct 06, 2021
Polygenic basis and biomedical consequences of telomere length variation.
Veryan Codd, Qingning Wang, Elias Allara, Crispin Musicha, Stephen Kaptoge, Svetlana Stoma, Tao Jiang, Stephen E Hamby, Peter S Braund, Vasiliki Bountziouka, Charley A Budgeon, Matthew Denniff, Chloe Swinfield, Manolo Papakonstantinou, Shilpi Sheth, Dominika E Nanus, Sophie C Warner, Minxian Wang, Amit V Khera, James Eales, Willem H Ouwehand, John R Thompson, Emanuele Di Angelantonio, Angela M Wood, Adam S Butterworth, John N Danesh, Christopher P Nelson, Nilesh J Samani
Nov 06, 2021
Published by: Nature genetics
Polygenic basis and biomedical consequences of telomere length variation.
Veryan Codd, Qingning Wang, Elias Allara, Crispin Musicha, Stephen Kaptoge, Svetlana Stoma, Tao Jiang, Stephen E Hamby, Peter S Braund, Vasiliki Bountziouka, Charley A Budgeon, Matthew Denniff, Chloe Swinfield, Manolo Papakonstantinou, Shilpi Sheth, Dominika E Nanus, Sophie C Warner, Minxian Wang, Amit V Khera, James Eales, Willem H Ouwehand, John R Thompson, Emanuele Di Angelantonio, Angela M Wood, Adam S Butterworth, John N Danesh, Christopher P Nelson, Nilesh J Samani
Nov 05, 2021
Telomeres, the end fragments of chromosomes, play key roles in cellular proliferation and senescence. Here we characterize the genetic architecture of naturally occurring variation in leukocyte telomere length (LTL) and identify...
Alcohol consumption and telomere length
A Topiwala, B Taschler, KP Ebmeier, S Smith, H Zhou, DF Levey, V Codd, NJ Samani, J Gelernter, TE Nichols, S Burgess
Apr 07, 2023
Alcohol consumption and telomere length
A Topiwala, B Taschler, KP Ebmeier, S Smith, H Zhou, DF Levey, V Codd, NJ Samani, J Gelernter, TE Nichols, S Burgess
Dec 08, 2022
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length.
Chen Li, Svetlana Stoma, Luca A Lotta, Sophie Warner, Eva Albrecht, Alessandra Allione, Pascal P Arp, Linda Broer, Jessica L Buxton, Alexessander Da Silva Couto Alves, Joris Deelen, Iryna O Fedko, Scott D Gordon, Tao Jiang, Robert Karlsson, Nicola Kerrison, Taylor K Loe, Massimo Mangino, Yuri Milaneschi, Benjamin Miraglio, Natalia Pervjakova, Alessia Russo, Ida Surakka, Ashley van der Spek, Josine E Verhoeven, Najaf Amin, Marian Beekman, Alexandra I Blakemore, Federico Canzian, Stephen E Hamby, Jouke-Jan Hottenga, Peter D Jones, Pekka Jousilahti, Reedik Mägi, Sarah E Medland, Grant W Montgomery, Dale R Nyholt, Markus Perola, Kirsi H Pietiläinen, Veikko Salomaa, Elina Sillanpää, H Eka Suchiman, Diana van Heemst, Gonneke Willemsen, Antonio Agudo, Heiner Boeing, Dorret I Boomsma, Maria-Dolores Chirlaque, Guy Fagherazzi, Pietro Ferrari, Paul Franks, Christian Gieger, Johan Gunnar Eriksson, Marc Gunter, Sara Hägg, Iiris Hovatta, Liher Imaz, Jaakko Kaprio, Rudolf Kaaks, Timothy Key, Vittorio Krogh, Nicholas G Martin, Olle Melander, Andres Metspalu, Concha Moreno, N Charlotte Onland-Moret, Peter Nilsson, Ken K Ong, Kim Overvad, Domenico Palli, Salvatore Panico, Nancy L Pedersen, Brenda WJH Penninx, J Ramón Quirós, Marjo Riitta Jarvelin, Miguel Rodríguez-Barranco, Robert A Scott, Gianluca Severi, P Eline Slagboom, Tim D Spector, Anne Tjonneland, Antonia Trichopoulou, Rosario Tumino, André G Uitterlinden, Yvonne T van der Schouw, Cornelia M van Duijn, Elisabete Weiderpass, Eros Lazzerini Denchi, Giuseppe Matullo, Adam S Butterworth, John Danesh, Nilesh J Samani, Nicholas J Wareham, Christopher P Nelson, Claudia Langenberg, Veryan Codd
Feb 21, 2020
Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.
Tetsushi Nakao, Alexander G Bick, Margaret A Taub, Seyedeh M Zekavat, Md M Uddin, Abhishek Niroula, Cara L Carty, John Lane, Michael C Honigberg, Joshua S Weinstock, Akhil Pampana, Christopher J Gibson, Gabriel K Griffin, Shoa L Clarke, Romit Bhattacharya, Themistocles L Assimes, Leslie S Emery, Adrienne M Stilp, Quenna Wong, Jai Broome, Cecelia A Laurie, Alyna T Khan, Albert V Smith, Thomas W Blackwell, Veryan Codd, Christopher P Nelson, Zachary T Yoneda, Juan M Peralta, Donald W Bowden, Marguerite R Irvin, Meher Boorgula, Wei Zhao, Lisa R Yanek, Kerri L Wiggins, James E Hixson, C Charles Gu, Gina M Peloso, Dan M Roden, Muagututi'a S Reupena, Chii-Min Hwu, Dawn L DeMeo, Kari E North, Shannon Kelly, Solomon K Musani, Joshua C Bis, Donald M Lloyd-Jones, Jill M Johnsen, Michael Preuss, Russell P Tracy, Patricia A Peyser, Dandi Qiao, Pinkal Desai, Joanne E Curran, Barry I Freedman, Hemant K Tiwari, Sameer Chavan, Jennifer A Smith, Nicholas L Smith, Tanika N Kelly, Bertha Hidalgo, L Adrienne Cupples, Daniel E Weeks, Nicola L Hawley, Ryan L Minster, Lifestyle and Genetic Adaptations Study (OLaGA) Group Samoan Obesity, Ranjan Deka, Take T Naseri, Lisa de Las Fuentes, Laura M Raffield, Alanna C Morrison, Paul S Vries, Christie M Ballantyne, Eimear E Kenny, Stephen S Rich, Eric A Whitsel, Michael H Cho, M Benjamin Shoemaker, Betty S Pace, John Blangero, Nicholette D Palmer, Braxton D Mitchell, Alan R Shuldiner, Kathleen C Barnes, Susan Redline, Sharon LR Kardia, Gonçalo R Abecasis, Lewis C Becker, Susan R Heckbert, Jiang He, Wendy Post, Donna K Arnett, Ramachandran S Vasan, Dawood Darbar, Scott T Weiss, Stephen T McGarvey, Mariza de Andrade, Yii-Der Ida Chen, Robert C Kaplan, Deborah A Meyers, Brian S Custer, Adolfo Correa, Bruce M Psaty, Myriam Fornage, JoAnn E Manson, Eric Boerwinkle, Barbara A Konkle, Ruth JF Loos, Jerome I Rotter, Edwin K Silverman, Charles Kooperberg, John Danesh, Nilesh J Samani, Siddhartha Jaiswal, Peter Libby, Patrick T Ellinor, Nathan Pankratz, Benjamin L Ebert, Alexander P Reiner, Rasika A Mathias, Ron Do, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Pradeep Natarajan
May 09, 2022
Human genetic studies support an inverse causal relationship between leukocyte telomere length (LTL) and coronary artery disease (CAD), but directionally mixed effects for LTL and diverse malignancies. Clonal hematopoiesis of...