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Results: 21
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.
Matthew J Sale, Emma Minihane, Noel R Monks, Rebecca Gilley, Frances M Richards, Kevin P Schifferli, Courtney L Andersen, Emma J Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I Jodrell, Paul D Smith, Simon J Cook
Dec 16, 2019
BRAF and MEK1/2 inhibitors are effective in melanoma but resistance inevitably develops. Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2 pathway inhibition is predominantly cytostatic, reflecting residual...
Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.
Matthew J Sale, Emma Minihane, Noel R Monks, Rebecca Gilley, Frances M Richards, Kevin P Schifferli, Courtney L Andersen, Emma J Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I Jodrell, Paul D Smith, Simon J Cook
Jun 21, 2019
The Effects of a High Fat Western Diet Along With Pregnancy on the Morphology and Contractile Function of the Heart
Vikki Rueda-Juarez
Jan 01, 0001
In the United States of America the obesity rate has reached an all-time high, with 40% of Americans having a BMI above 30.0. Obesity is correlated with cardiac hypertrophy, which is the enlargement of the heart due to increased...
cardiac hypertrophy contractile dysfunction pathological physiological Hypertension Sarcomere Biology Life Sciences
Published by: Ursinus College
Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors
Matthew J. Sale, Emma Minihane, Noel R. Monks, Rebecca Gilley, Frances M. Richards, Kevin P. Schifferli, Courtney L. Andersen, Emma J. Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R. Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I. Jodrell, Paul D. Smith, Simon J. Cook
Nov 13, 2020
Analysis of Plasma Cholesterol Levels With a High Fat Diet Induced-Obesity Mouse Model
Vikki Rueda-Juarez
Jan 01, 0001
Obesity is a complex chronic disease that has been rapidly increasing in the United States. Cardiovascular diseases such as coronary artery disease, atherosclerosis, and hypertension have all been linked to obesity. Chronic...
cardiovascular disease obesity Cholesterol High fat diet plaque formation Coronary Artery Disease Biology Life Sciences
Published by: Ursinus College
A mild, copper-catalysed amide deprotection strategy
Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2 is reported. This allows use of the tert-butyl...
A mild, copper-catalysed amide deprotection strategy
Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2 is reported. This allows use of the tert-butyl...
Development and piloting of a highly tailored digital intervention to support adherence to antihypertensive medications as an adjunct to primary care consultations.
OBJECTIVES: This paper describes the systematic development and piloting of a highly tailored text and voice message intervention to increase adherence to medication in primary care. METHODS: Following the Medical Research...
Hypertension interactive voice response Medication Adherence pilot intervention text messages Antihypertensive Agents Feasibility Studies Habits Humans Hypertension Medication Adherence Patient Acceptance of Health Care Patient Participation Pilot Projects Primary Health Care qualitative research Reminder Systems social support Telemedicine Text Messaging United Kingdom
Prediction of Piezoelectric Tile Performance in Flat and Mountainous Terrains Through Deep Neural Network
Jitendra Adhikari, Kamalpreet Singh, Anjani Kumar Sagar, Vikki Kumar Sharma, Rajeev Kumar, Satish Chandra Jain
Sep 13, 2023
Piezoelectric tiles harvest mechanical vibrations and convert them into electrical energy, making them an attractive energy-harvesting technology. However, their performance is heavily influenced by the terrain where they are...
energy harvesting experiment Finite element analysis Machine Learning piezoelectric materials /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2612 name=Numerical Analysis /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1000 name=General
Prediction of Piezoelectric Tile Performance in Flat and Mountainous Terrains Through Deep Neural Network
Jitendra Adhikari, Kamalpreet Singh, Anjani Kumar Sagar, Vikki Kumar Sharma, Rajeev Kumar, Satish Chandra Jain
Sep 13, 2023
Piezoelectric tiles harvest mechanical vibrations and convert them into electrical energy, making them an attractive energy-harvesting technology. However, their performance is heavily influenced by the terrain where they are...
energy harvesting experiment Finite element analysis Machine Learning piezoelectric materials /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/2600/2612 name=Numerical Analysis /dk/atira/pure/subjectarea/asjc/2600/2611 name=Modelling and Simulation /dk/atira/pure/subjectarea/asjc/1000 name=General
RApid Primary care Initiation of Drug treatment for Transient Ischaemic Attack (RAPID-TIA)
Duncan Edwards, Kate Fletcher, Rachel Deller, Richard McManus, Daniel Lasserson, Matthew Giles, Don Sims, John Norrie, Graham McGuire, Simon Cohn, Fiona Whittle, Vikki Hobbs, Christopher Weir, Jonathan Mant
Jul 17, 2013
Antihypertensive Agents Aspirin Cardiovascular Agents Clinical Protocols Dipyridamole Drug Administration Schedule Drug Therapy Combination Emergency Service hospital England Feasibility Studies General Practice Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Ischemic Attack Transient Pilot Projects Primary Health Care Referral and Consultation Research Design Secondary Prevention Simvastatin Time Factors Treatment Outcome
Marketing and clinical trials
David Francis, Ian Roberts, Diana R Elbourne, Haleema Shakur, Rosemary C Knight, Jo Garcia, Claire Snowdon, Vikki A Entwistle, Alison M McDonald, Adrian M Grant, Marion K Campbell
Jun 14, 2011
BACKGROUND: Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous...
What influences recruitment to randomised controlled trials? A review of trials funded by two UK funding agencies.
Computational Fluorescence Suppression in Shifted Excitation Raman Spectroscopy
Nia C. Jenkins, Katjana Ehrlich, Andras Kufcsak, Stephanos Yerolatsitis, Susan Fernandes, Irene Young, Katie Hamilton, Harry A.C. Wood, Tom Quinn, Vikki Young, Ahsan R. Akram, James M. Stone, Robert R. Thomson, Keith Finlayson, Kevin Dhaliwal, Sohan Seth
Aug 31, 2023
Fiber-based Raman spectroscopy in the context of <italic>in vivo</italic> biomedical application suffers from the presence of background fluorescence from the surrounding tissue that might mask the crucial but...
Computational Fluorescence Suppression in Shifted Excitation Raman Spectroscopy
Nia C. Jenkins, Katjana Ehrlich, Andras Kufcsak, Stephanos Yerolatsitis, Susan Fernandes, Irene Young, Katie Hamilton, Harry A.C. Wood, Tom Quinn, Vikki Young, Ahsan R. Akram, James M. Stone, Robert R. Thomson, Keith Finlayson, Kevin Dhaliwal, Sohan Seth
Aug 31, 2023
Fiber-based Raman spectroscopy in the context of <italic>in vivo</italic> biomedical application suffers from the presence of background fluorescence from the surrounding tissue that might mask the crucial but...
Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma.
Alexander M Newman, Masood Zaka, Peixun Zhou, Alex E Blain, Amy Erhorn, Amy Barnard, Rachel E Crossland, Sarah Wilkinson, Amir Enshaei, Julian De Zordi, Fiona Harding, Mary Taj, Katrina M Wood, Despina Televantou, Suzanne D Turner, GA Amos Burke, Christine J Harrison, Simon Bomken, Chris M Bacon, Vikki Rand
Sep 17, 2021
Children with B-cell non-Hodgkin lymphoma (B-NHL) have an excellent chance of survival, however, current clinical risk stratification places as many as half of patients in a high-risk group receiving very intensive...
Better post-operative prediction and management of chronic pain in adults after total knee replacement
Rachael Gooberman-Hill, Vikki Wylde, Wendy Bertram, Andrew J. Moore, Rafael Pinedo-Villanueva, Emily Sanderson, Jane Dennis, Shaun Harris, Andrew Judge, Sian Noble, Andrew D. Beswick, Amanda Burston, Tim J Peters, Julie Bruce, Christopher Eccleston, Stewart Long, David A. Walsh, Nicholas Howells, Simon White, Andrew J. Price, Nigel Arden, Andrew Toms, Candida S. McCabe, Ashley W. Blom
Jun 30, 2023
Background: The treatment of osteoarthritis with knee replacement aims to reduce pain and disability. However, some people experience chronic pain.
Objectives: To improve outcomes for people with chronic pain after knee...
/dk/atira/pure/subjectarea/asjc/2700/2719 name=Health Policy /dk/atira/pure/subjectarea/asjc/2700/2718 name=Health Informatics /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Fc-null anti-PD-1 monoclonal antibodies deliver optimal checkpoint blockade in diverse immune environments.
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, HT Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers
Jan 28, 2022
BACKGROUND: Despite extensive clinical use, the mechanisms that lead to therapeutic resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain elusive. Here, we sought to determine how interactions...
Better post-operative prediction and management of chronic pain in adults after total knee replacement
Rachael Gooberman-Hill, Vikki Wylde, Wendy Bertram, Andrew J. Moore, Rafael Pinedo-Villanueva, Emily Sanderson, Jane Dennis, Shaun Harris, Andrew Judge, Sian Noble, Andrew D. Beswick, Amanda Burston, Tim J Peters, Julie Bruce, Christopher Eccleston, Stewart Long, David A. Walsh, Nicholas Howells, Simon White, Andrew J. Price, Nigel Arden, Andrew Toms, Candida S. McCabe, Ashley W. Blom
Jun 30, 2023
Background: The treatment of osteoarthritis with knee replacement aims to reduce pain and disability. However, some people experience chronic pain.
Objectives: To improve outcomes for people with chronic pain after knee...
/dk/atira/pure/subjectarea/asjc/2700/2719 name=Health Policy /dk/atira/pure/subjectarea/asjc/2700/2718 name=Health Informatics /dk/atira/pure/subjectarea/asjc/2700/2739 name=Public Health, Environmental and Occupational Health /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Chun Gong, Joanna A Krupka, Jie Gao, Nicholas F Grigoropoulos, George Giotopoulos, Ryan Asby, Michael Screen, Zelvera Usheva, Francesco Cucco, Sharon Barrans, Daniel Painter, Nurmahirah Binte Mohammed Zaini, Björn Haupl, Susanne Bornelöv, Igor Ruiz De Los Mozos, Wei Meng, Peixun Zhou, Alex E Blain, Sorcha Forde, Jamie Matthews, Michelle Guet Khim Tan, GA Amos Burke, Siu Kwan Sze, Philip Beer, Cathy Burton, Peter Campbell, Vikki Rand, Suzanne D Turner, Jernej Ule, Eve Roman, Reuben Tooze, Thomas Oellerich, Brian J Huntly, Martin Turner, Ming-Qing Du, Shamith A Samarajiwa, Daniel J Hodson
Jul 30, 2021
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here, we show that loss-of-function...
Burkitt lymphoma DDX3X Myc RNA helicase Germinal Center proteotoxic stress Translation Adolescent Adult Aged Aged 80 and over Animals B-Lymphocytes Cell Line Tumor Child Child Preschool DEAD-box RNA Helicases Endoplasmic reticulum stress Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Humans Loss of Function Mutation Lymphoma B-Cell Male Mice Transgenic Middle Aged Minor Histocompatibility Antigens Neoplasm Proteins Protein Biosynthesis Proteome Proteostasis Proto-Oncogene Proteins c-myc Young Adult
Vitamin D insufficiency in COVID-19 and influenza A, and critical illness survivors
Emma A Hurst, Richard J Mellanby, Ian Handel, David M Griffith, Adriano G Rossi, Timothy S Walsh, Manu Shankar-Hari, Jake Dunning, Natalie Z Homer, Scott G Denham, Kerri Devine, Paul A Holloway, Shona C Moore, Ryan S Thwaites, Romit J Samanta, Hayley E Hardwick, Wilna Oosthuyzen, Lance Turtle, Malcolm G Semple, Peter J M Openshaw, J Kenneth Baillie, ISARIC4C investigators, J Kenneth Baillie, Gail Carson, Beatrice Alex, Benjamin Bach, Wendy S Barclay, Debby Bogaert, Meera Chand, Graham S Cooke, Annemarie B Docherty, Ana Da Silva Filipe, Tom Fletcher, Christopher A Green, Ewen M Harrison, Julian A Hiscox, Peter W Horby, Samreen Ijaz, Saye Khoo, Paul Klenerman, Andrew Law, Wei Shen Lim, Alexander J Mentzer, Laura Merson, Alison M Meynert, Mahdad Noursadeghi, Massimo Palmarini, William A Paxton, Georgios Pollakis, Nicholas Price, Andrew Rambaut, David L Robertson, Clark D Russell, Vanessa Sancho-Shimizu, Janet T Scott, Thushan de Silva, Louise Sigfrid, Tom Solomon, Shiranee Sriskandan, David Stuart, Charlotte Summers, Richard S Tedder, Emma C Thomson, A A Roger Thompson, Lance C W Turtle, Rishi K Gupta, Maria Zambon, Hayley Hardwick, Chloe Donohue, Ruth Lyons, Fiona Griffiths, Lisa Norman, Riinu Pius, Thomas M Drake, Cameron J Fairfield, Stephen R Knight, Kenneth A Mclean, Derek Murphy, Catherine A Shaw, Jo Dalton, Michelle Girvan, Egle Saviciute, Stephanie Roberts, Janet Harrison, Laura Marsh, Marie Connor, Sophie Halpin, Clare Jackson, Carrol Gamble, Gary Leeming, Murray Wham, Sara Clohisey, Ross Hendry, James Scott-Brown, William Greenhalf, Victoria Shaw, Sara McDonald, Seán Keating, Katie A Ahmed, Jane A Armstrong, Milton Ashworth, Innocent G Asiimwe, Siddharth Bakshi, Samantha L Barlow, Laura Booth, Benjamin Brennan, Katie Bullock, Benjamin W A Catterall, Jordan J Clark, Emily A Clarke, Sarah Cole, Louise Cooper, Helen Cox, Christopher Davis, Oslem Dincarslan, Chris Dunn, Philip Dyer, Angela Elliott, Anthony Evans, Lorna Finch, Lewis W S Fisher, Terry Foster, Isabel Garcia-Dorival, Philip Gunning, Catherine Hartley, Rebecca L Jensen, Christopher B Jones, Trevor R Jones, Shadia Khandaker, Katharine King, Robyn T Kiy, Chrysa Koukorava, Annette Lake, Suzannah Lant, Diane Latawiec, Lara Lavelle-Langham, Daniella Lefteri, Lauren Lett, Lucia A Livoti, Maria Mancini, Sarah McDonald, Laurence McEvoy, John McLauchlan, Soeren Metelmann, Nahida S Miah, Joanna Middleton, Joyce Mitchell, Ellen G Murphy, Rebekah Penrice-Randal, Jack Pilgrim, Tessa Prince, Will Reynolds, P Matthew Ridley, Debby Sales, Victoria E Shaw, Rebecca K Shears, Benjamin Small, Krishanthi S Subramaniam, Agnieska Szemiel, Aislynn Taggart, Jolanta Tanianis-Hughes, Jordan Thomas, Erwan Trochu, Libby van Tonder, Eve Wilcock, J Eunice Zhang, Lisa Flaherty, Nicole Maziere, Emily Cass, Alejandra Doce Carracedo, Nicola Carlucci, Anthony Holmes, Hannah Massey, Lee Murphy, Nicola Wrobel, Sarah McCafferty, Kirstie Morrice, Alan MacLean, Kayode Adeniji, Daniel Agranoff, Ken Agwuh, Dhiraj Ail, Erin L Aldera, Ana Alegria, Brian Angus, Abdul Ashish, Dougal Atkinson, Shahedal Bari, Gavin Barlow, Stella Barnass, Nicholas Barrett, Christopher Bassford, Sneha Basude, David Baxter, Michael Beadsworth, Jolanta Bernatoniene, John Berridge, Nicola Best, Pieter Bothma, David Chadwick, Robin Brittain-Long, Naomi Bulteel, Tom Burden, Andrew Burtenshaw, Vikki Caruth, Duncan Chambler, Nigel Chee, Jenny Child, Srikanth Chukkambotla, Tom Clark, Paul Collini, Catherine Cosgrove, Jason Cupitt, Maria-Teresa Cutino-Moguel, Paul Dark, Chris Dawson, Samir Dervisevic, Phil Donnison, Sam Douthwaite, Ingrid DuRand, Ahilanadan Dushianthan, Tristan Dyer, Cariad Evans, Chi Eziefula, Chrisopher Fegan, Adam Finn, Duncan Fullerton, Sanjeev Garg, Atul Garg, Effrossyni Gkrania-Klotsas, Jo Godden, Arthur Goldsmith, Clive Graham, Elaine Hardy, Stuart Hartshorn, Daniel Harvey, Peter Havalda, Daniel B Hawcutt, Maria Hobrok, Luke Hodgson, Anil Hormis, Michael Jacobs, Susan Jain, Paul Jennings, Agilan Kaliappan, Vidya Kasipandian, Stephen Kegg, Michael Kelsey, Jason Kendall, Caroline Kerrison, Ian Kerslake, Oliver Koch, Gouri Koduri, George Koshy, Shondipon Laha, Steven Laird, Susan Larkin, Tamas Leiner, Patrick Lillie, James Limb, Vanessa Linnett, Jeff Little, Mark Lyttle, Michael MacMahon, Emily MacNaughton, Ravish Mankregod, Huw Masson, Elijah Matovu, Katherine McCullough, Ruth McEwen, Manjula Meda, Gary Mills, Jane Minton, Mariyam Mirfenderesky, Kavya Mohandas, Quen Mok, James Moon, Elinoor Moore, Patrick Morgan, Craig Morris, Katherine Mortimore, Samuel Moses, Mbiye Mpenge, Rohinton Mulla, Michael Murphy, Megan Nagel, Thapas Nagarajan, Mark Nelson, Matthew K O'Shea, Igor Otahal, Marlies Ostermann, Mark Pais, Carlo Palmieri, Selva Panchatsharam, Danai Papakonstantinou, Hassan Paraiso, Brij Patel, Natalie Pattison, Justin Pepperell, Mark Peters, Mandeep Phull, Stefania Pintus, Jagtur Singh Pooni, Frank Post, David Price, Rachel Prout, Nikolas Rae, Henrik Reschreiter, Tim Reynolds, Neil Richardson, Mark Roberts, Devender Roberts, Alistair Rose, Guy Rousseau, Brendan Ryan, Taranprit Saluja, Aarti Shah, Prad Shanmuga, Anil Sharma, Anna Shawcross, Jeremy Sizer, Richard Smith, Catherine Snelson, Nick Spittle, Nikki Staines, Tom Stambach, Richard Stewart, Pradeep Subudhi, Tamas Szakmany, Kate Tatham, JO Thomas, Chris Thompson, Robert Thompson, Ascanio Tridente, Darell Tupper-Carey, Mary Twagira, Andrew Ustianowski, Nick Vallotton, Lisa Vincent-Smith, Shico Visuvanathan, Alan Vuylsteke, Sam Waddy, Rachel Wake, Andrew Walden, Ingeborg Welters, Tony Whitehouse, Paul Whittaker, Ashley Whittington, Padmasayee Papineni, Meme Wijesinghe, Martin Williams, Lawrence Wilson, Stephen Winchester, Martin Wiselka, Adam Wolverson, Daniel G Wootton, Andrew Workman, Bryan Yates, Peter Young, Antonia Ying Wai Ho
Oct 26, 2021
Objectives: The steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy vitamin D (25(OH)D) measurements in...