Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease.
Thomas J Nicholls,
Gábor Zsurka,
Viktoriya Peeva,
Susanne Schöler,
Roman J Szczesny,
Dominik Cysewski,
Aurelio Reyes,
Cornelia Kornblum,
Monica Sciacco,
Maurizio Moggio,
Andrzej Dziembowski,
Wolfram S Kunz,
Michal Minczuk
Nov 13, 2017
MGME1, also known as Ddk1 or C20orf72, is a mitochondrial exonuclease found to be involved in the processing of mitochondrial DNA (mtDNA) during replication. Here, we present detailed insights on the role of MGME1 in mtDNA...