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Paired Nasopharyngeal and Deep Lung Testing for Severe Acute Respiratory Syndrome Coronavirus-2 Reveals a Viral Gradient in Critically Ill Patients
Islam Hamed, Nesreen Shaban, Marwan Nassar, Dilek Cayir, Sam Love, Martin D Curran, Stephen Webb, Huina Yang, Katherine Watson, Anthony Rostron, Vilas Navapurkar, Razeen Mahroof, Andrew Conway Morris
Oct 13, 2020
Ventilator-associated pneumonia in critically ill patients with COVID-19
Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Solderholm, Sally Forrest, Sushmita Sridhar, Nicholas M. Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefin Bartholdson Scott, Andrew Conway Morris
Jan 11, 2021
Abstract: Background: Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit...
Ventilator-associated pneumonia in critically ill patients with COVID-19.
Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar, Nicholas M Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefin Bartholdson Scott, Andrew Conway Morris
Jan 04, 2021
Ventilator-associated pneumonia in critically ill patients with COVID-19
Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar, Nicholas M. Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefin Bartholdson Scott, Andrew Conway Morris
Aug 02, 2021
Abstract: Background: Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit...
The Removal of Airborne Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Other Microbial Bioaerosols by Air Filtration on Coronavirus Disease 2019 (COVID-19) Surge Units.
Andrew Conway Morris, Katherine Sharrocks, Rachel Bousfield, Leanne Kermack, Mailis Maes, Ellen Higginson, Sally Forrest, Joana Pereira-Dias, Claire Cormie, Tim Old, Sophie Brooks, Islam Hamed, Alicia Koenig, Andrew Turner, Paul White, R Andres Floto, Gordon Dougan, Effrossyni Gkrania-Klotsas, Theodore Gouliouris, Stephen Baker, Vilas Navapurkar
Nov 03, 2021
Rapid Assay for Sick Children with Acute Lung infection Study (RASCALS)
John Alexander Clark, Iain Robert Louis Kean, Martin D Curran, Fahad Khokhar, Deborah White, Esther Daubney, Andrew Conway Morris, Vilas Navapurkar, Josefin Bartholdson Scott, Mailis Maes, Rachel Bousfield, Theodore Gouliouris, Shruti Agrawal, David Inwald, Zhenguang Zhang, M Estée Török, Stephen Baker, Nazima Pathan
Jan 10, 2022
INTRODUCTION: Lower respiratory tract infection (LRTI) is the most commonly treated infection in critically ill children. Pathogens are infrequently identified on routine respiratory culture, and this is a time-consuming...
Ventilator-associated pneumonia in critically ill patients with COVID-19
Mailis Maes, Ellen Higginson, Joana Pereira-Dias, Martin D. Curran, Surendra Parmar, Fahad Khokhar, Delphine Cuchet-Lourenço, Janine Lux, Sapna Sharma-Hajela, Benjamin Ravenhill, Islam Hamed, Laura Heales, Razeen Mahroof, Amelia Soderholm, Sally Forrest, Sushmita Sridhar, Nicholas M. Brown, Stephen Baker, Vilas Navapurkar, Gordon Dougan, Josefin Bartholdson Scott, Andrew Conway Morris
Apr 07, 2021
Abstract: Background: Pandemic COVID-19 caused by the coronavirus SARS-CoV-2 has a high incidence of patients with severe acute respiratory syndrome (SARS). Many of these patients require admission to an intensive care unit...
The rapid detection of respiratory pathogens in critically ill children.
John A Clark, Andrew Conway Morris, Martin D Curran, Deborah White, Esther Daubney, Iain RL Kean, Vilas Navapurkar, Josefin Bartholdson Scott, Mailis Maes, Rachel Bousfield, M Estée Török, David Inwald, Zhenguang Zhang, Shruti Agrawal, Constantinos Kanaris, Fahad Khokhar, Theodore Gouliouris, Stephen Baker, Nazima Pathan
Feb 10, 2023
The rapid detection of respiratory pathogens in critically ill children.
John A Clark, Andrew Conway Morris, Martin D Curran, Deborah White, Esther Daubney, Iain RL Kean, Vilas Navapurkar, Josefin Bartholdson Scott, Mailis Maes, Rachel Bousfield, M Estée Török, David Inwald, Zhenguang Zhang, Shruti Agrawal, Constantinos Kanaris, Fahad Khokhar, Theodore Gouliouris, Stephen Baker, Nazima Pathan
Jan 11, 2023
Do player performance, real sport experience, and gender affect movement patterns during equivalent exergame?
This study compared the movement patterns of forty-six college students, playing bouts of swimming exergame, while categorized based on their playing performance, gender, and prior experience of real swimming and exergames....
biomechanics Front crawl performance Research methods & experimental design Virtual sport /dk/atira/pure/subjectarea/asjc/1200/1201 name=Arts and Humanities (miscellaneous) /dk/atira/pure/subjectarea/asjc/1700/1709 name=Human-Computer Interaction /dk/atira/pure/subjectarea/asjc/3200/3200 name=General Psychology
Muscle activation behavior in a swimming exergame
The effects of playing intensity and prior exergame and sport experience on the activation patterns of upper limb muscles during a swimming exergame were investigated. Surface electromyography of Biceps Brachii, Triceps...
Do player performance, real sport experience, and gender affect movement patterns during equivalent exergame?
This study compared the movement patterns of forty-six college students, playing bouts of swimming exergame, while categorized based on their playing performance, gender, and prior experience of real swimming and exergames....
biomechanics Front crawl performance Research methods & experimental design Virtual sport /dk/atira/pure/subjectarea/asjc/1200/1201 name=Arts and Humanities (miscellaneous) /dk/atira/pure/subjectarea/asjc/1700/1709 name=Human-Computer Interaction /dk/atira/pure/subjectarea/asjc/3200/3200 name=General Psychology
Does exergaming drive future physical activity and sport intentions?
We studied how usability and playability of sport exergames affect future intentions of participation in physical activity or actual sport. We employed questionnaires to measure participants’ enjoyment, usability...
Does exergaming drive future physical activity and sport intentions?
We studied how usability and playability of sport exergames affect future intentions of participation in physical activity or actual sport. We employed questionnaires to measure participants’ enjoyment, usability...
Development and implementation of a customised rapid syndromic diagnostic test for severe pneumonia.
Vilas Navapurkar, Josefin Bartholdson Scott, Mailis Maes, Thomas P Hellyer, Ellen Higginson, Sally Forrest, Joana Pereira-Dias, Surendra Parmar, Emma Heasman-Hunt, Petra Polgarova, Joanne Brown, Lissamma Titti, William PW Smith, Jonathan Scott, Anthony Rostron, Matthew Routledge, David Sapsford, M Estée Török, Ronan McMullan, David A Enoch, Vanessa Wong, VAP-Rapid investigators, Martin D Curran, Nicholas M Brown, A John Simpson, Jurgen Herre, Gordon Dougan, Andrew Conway Morris
Dec 08, 2022
Muscle activation behavior in a swimming exergame
The effects of playing intensity and prior exergame and sport experience on the activation patterns of upper limb muscles during a swimming exergame were investigated. Surface electromyography of Biceps Brachii, Triceps...
Physiological demands of a swimming-based video game
Pooya Soltani, Pedro Figueiredo, João Ribeiro, Ricardo J. Fernandes, João Paulo Vilas-Boas
Dec 31, 2017
Active video games (exergames) may provide short-term increase in energy expenditure. We explored the effects of gender and prior experience on aerobic and anaerobic energy systems contributions, and the activity profiles of...
Physiological demands of a swimming-based video game
Pooya Soltani, Pedro Figueiredo, João Ribeiro, Ricardo J. Fernandes, João Paulo Vilas-Boas
Dec 31, 2017
Active video games (exergames) may provide short-term increase in energy expenditure. We explored the effects of gender and prior experience on aerobic and anaerobic energy systems contributions, and the activity profiles of...
A Titratable Cell Lysis-on-Demand System for Droplet-Compartmentalized Ultrahigh-Throughput Screening in Functional Metagenomics and Directed Evolution.
Che Fai Alex Wong, Liisa van Vliet, Swapnil Vilas Bhujbal, Chengzhi Guo, Marit Sletmoen, Bjørn Torger Stokke, Florian Hollfelder, Rahmi Lale
Aug 13, 2021
Dissecting multi drug resistance in head and neck cancer cells using multicellular tumor spheroids.
Mohammad Azharuddin, Karin Roberg, Ashis Kumar Dhara, Mayur Vilas Jain, Padraig Darcy, Jorma Hinkula, Nigel K H Slater, Hirak K Patra
Jan 29, 2020
One of the hallmarks of cancers is their ability to develop resistance against therapeutic agents. Therefore, developing effective in vitro strategies to identify drug resistance remains of paramount importance for successful...
Dissecting multi drug resistance in head and neck cancer cells using multicellular tumor spheroids.
Mohammad Azharuddin, Karin Roberg, Ashis Kumar Dhara, Mayur Vilas Jain, Padraig Darcy, Jorma Hinkula, Nigel Kh Slater, Hirak K Patra
Feb 24, 2020
One of the hallmarks of cancers is their ability to develop resistance against therapeutic agents. Therefore, developing effective in vitro strategies to identify drug resistance remains of paramount importance for successful...
In vivo alpha-V beta-3 integrin expression in human aortic atherosclerosis.
William S Jenkins, Alex T Vesey, Anna Vickers, Anoushka Neale, Catriona Moles, Martin Connell, Nikhil Vilas Joshi, Christophe Lucatelli, Alison M Fletcher, James C Spratt, Saeed Mirsadraee, Edwin JR van Beek, James HF Rudd, David E Newby, Marc R Dweck
Jul 24, 2019
OBJECTIVES: Intraplaque angiogenesis and inflammation are key promoters of atherosclerosis and are mediated by the alpha-V beta-3 (αvβ3) integrin pathway. We investigated the applicability of the αvβ3-integrin receptor-selective...
Atherosclerosis Computed tomography integrin positron emission tomography Aged Aorta Thoracic Aortic Diseases Atherosclerosis Carboxylic Acids Carotid Stenosis Cyclobutanes Female Humans Image Interpretation Computer-Assisted Integrin alphaVbeta3 Male Middle Aged Myocardial Infarction Positron Emission Tomography Computed Tomography Radiopharmaceuticals Vascular Calcification
Genomewide Association Studies of LRRK2 Modifiers of Parkinson's Disease.
Dongbing Lai, Babak Alipanahi, Pierre Fontanillas, Tae-Hwi Schwantes-An, Jan Aasly, Roy N Alcalay, Gary W Beecham, Daniela Berg, Susan Bressman, Alexis Brice, Kathrin Brockman, Lorraine Clark, Mark Cookson, Sayantan Das, Vivianna Van Deerlin, Jordan Follett, Matthew J Farrer, Joanne Trinh, Thomas Gasser, Stefano Goldwurm, Emil Gustavsson, Christine Klein, Anthony E Lang, J William Langston, Jeanne Latourelle, Timothy Lynch, Karen Marder, Connie Marras, Eden R Martin, Cory Y McLean, Helen Mejia-Santana, Eric Molho, Richard H Myers, Karen Nuytemans, Laurie Ozelius, Haydeh Payami, Deborah Raymond, Ekaterina Rogaeva, Michael P Rogers, Owen A Ross, Ali Samii, Rachel Saunders-Pullman, Birgitt Schüle, Claudia Schulte, William K Scott, Caroline Tanner, Eduardo Tolosa, James E Tomkins, Dolores Vilas, John Q Trojanowski, 23andMe Research Team, Ryan Uitti, Jeffery M Vance, Naomi P Visanji, Zbigniew K Wszolek, Cyrus P Zabetian, Anat Mirelman, Nir Giladi, Avi Orr Urtreger, Paul Cannon, Brian Fiske, Tatiana Foroud
Jul 29, 2021
OBJECTIVE: The aim of this study was to search for genes/variants that modify the effect of LRRK2 mutations in terms of penetrance and age-at-onset of Parkinson's disease. METHODS: We performed the first genomewide association...
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