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A method to infer positive selection from marker dynamics in an asexual population.
MOTIVATION: The observation of positive selection acting on a mutant indicates that the corresponding mutation has some form of functional relevance. Determining the fitness effects of mutations thus has relevance to many...
Evaluating genetic drift in time-series evolutionary analysis.
The Wright-Fisher model is the most popular population model for describing the behaviour of evolutionary systems with a finite population size. Approximations have commonly been used but the model itself has rarely been tested...
The repertoire of mutational signatures in human cancer.
Ludmil B Alexandrov, Jaegil Kim, Nicholas J Haradhvala, Mi Ni Huang, Alvin Wei Tian Ng, Yang Wu, Arnoud Boot, Kyle R Covington, Dmitry A Gordenin, Erik N Bergstrom, SM Ashiqul Islam, Nuria Lopez-Bigas, Leszek J Klimczak, John R McPherson, Sandro Morganella, Radhakrishnan Sabarinathan, David A Wheeler, Ville Mustonen, PCAWG Mutational Signatures Working Group, Gad Getz, Steven G Rozen, Michael R Stratton, PCAWG Consortium
Feb 04, 2021
Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature1. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium2 of...
How infectious diseases arrived in the colonial Americas.
Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.
human Genetics Virus microbiology HBV infectious disease Genomics Africa paleovirology b19v paleogenomics Ancient Viruses Humans Communicable Diseases Americas Mexico
Published by: eLife
How infectious diseases arrived in the colonial Americas.
Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.
Adolescent cannabis use, baseline prodromal symptoms and the risk of psychosis.
Antti Mustonen, Solja Niemelä, Tanja Nordström, Graham K Murray, Pirjo Mäki, Erika Jääskeläinen, Jouko Miettunen
May 11, 2018
BACKGROUND: The association between cannabis use and the risk of psychosis has been studied extensively but the temporal order still remains controversial. Aims To examine the association between cannabis use in adolescence and...
Nail abnormalities identified in an ageing study of 30 inbred mouse strains.
Sarah C Linn, Allison M Mustonen, Kathleen A Silva, Victoria E Kennedy, Beth A Sundberg, Lesley S Bechtold, Sarah Alghamdi, Robert Hoehndorf, Paul N Schofield, John P Sundberg
Oct 03, 2018
nail dystrophy pododermatitis circumscripta subungual intraosseous epidermoid inclusion cysts aging Animals Bone Remodeling Cross-Sectional Studies Epidermal Cyst Female Inflammation Keratin-1 Keratin-10 Keratosis Longitudinal Studies Male Metaplasia Mice Mice Inbred Strains Nails Malformed Toe Phalanges
Using Group Model Building to Describe the System Driving Unhealthy Eating and Identify Intervention Points
Leonor Guariguata, Etiënne Aja Rouwette, Madhuvanti M Murphy, Arlette Saint Ville, Leith L Dunn, Gordon M Hickey, Waneisha Jones, T Alafia Samuels, Nigel Unwin
Jan 17, 2020
Many Small Island Developing States of the Caribbean experience a triple burden of malnutrition with high rates of obesity, undernutrition in children, and iron deficiency anemia in women of reproductive age, driven by an...
Caribbean NCDs agricultural development food sovereignty group model building small islands Systems science unhealthy diet Adolescent Caribbean Region Child Child Nutrition Disorders Child Preschool Diet Feeding Behavior Female Humans Jamaica Male Nutrition Policy Policy Making Saint Kitts and Nevis Saint Vincent and the Grenadines stakeholder participation Systems Analysis Young Adult
Classification of degenerative parkinsonism subtypes by support-vector-machine analysis and striatal 123I-FP-CIT indices.
Nicolas Nicastro, Jennifer Wegrzyk, Maria Giulia Preti, Vanessa Fleury, Dimitri Van de Ville, Valentina Garibotto, Pierre R Burkhard
Apr 26, 2019
OBJECTIVES: To provide an automated classification method for degenerative parkinsonian syndromes (PS) based on semiquantitative 123I-FP-CIT SPECT striatal indices and support-vector-machine (SVM) analysis. METHODS: 123I-FP-CIT...
Residual porosity of 3D-LAM-printed stainless-steel electrodes allows galvanic exchange platinisation
James Weber, Andrew J. Wain, Heidi Piili, Ville Pekka Matilainen, Anne Vuorema, Gary A. Attard, Frank Marken
Apr 27, 2016
Stainless-steel rods were manufactured by laser additive manufacturing (LAM or "3D-printing") from a stainless-steel (316L) powder precursor, and then investigated and compared to conventional stainless steel in...
Using Group Model Building to Describe the System Driving Unhealthy Eating and Identify Intervention Points
Many Small Island Developing States of the Caribbean experience a triple burden of malnutrition with high rates of obesity, undernutrition in children, and iron deficiency anemia in women of reproductive age, driven by an...
How infectious diseases arrived in the colonial Americas
Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.
Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.
Thomas McKerrell, Thaidy Moreno, Hannes Ponstingl, Niccolo Bolli, João ML Dias, German Tischler, Vincenza Colonna, Bridget Manasse, Anthony Bench, David Bloxham, Bram Herman, Danielle Fletcher, Naomi Park, Michael A Quail, Nicla Manes, Clare Hodkinson, Joanna Baxter, Jorge Sierra, Theodora Foukaneli, Alan J Warren, Jianxiang Chi, Paul Costeas, Roland Rad, Brian Huntly, Carolyn Grove, Zemin Ning, Chris Tyler-Smith, Ignacio Varela, Mike Scott, Josep Nomdedeu, Ville Mustonen, George S Vassiliou
Mar 18, 2019
The diagnosis of hematologic malignancies relies on multidisciplinary workflows involving morphology, flow cytometry, cytogenetic, and molecular genetic analyses. Advances in cancer genomics have identified numerous recurrent...
Carrier Proteins DNA (Cytosine-5-)-Methyltransferases DNA Methyltransferase 3A Female Formins Genomics Hematologic Neoplasms Histone-Lysine N-Methyltransferase Humans Leukemia Myeloid Male Mutation Myelodysplastic Syndromes Myeloid-Lymphoid Leukemia Protein Oncogene Proteins Fusion fms-Like Tyrosine Kinase 3
Improved EEG source localization with Bayesian uncertainty modelling of unknown skull conductivity
Electroencephalography (EEG) source imaging is an ill-posed inverse problem that requires accurate conductivity modelling of the head tissues, especially the skull. Unfortunately, the conductivity values are difficult to...
A Combined Theory of Change-Group Model Building Approach to Evaluating “Farm to Fork” Models for School Feeding in the Caribbean
There is a scarcity of research on building nutrition-sensitive value chains (NSVCs) to improve diets and nutrition outcomes of populations in the Caribbean. This study contributes to filling this research gap by...
Effect of natural weathering on water absorption and pore size distribution in thermally modified wood determined by nuclear magnetic resonance
Chenyang Cai, Muhammad Asadullah Javed, Sanna Komulainen, Ville-Veikko Telkki, Antti Haapala, Henrik Heräjärvi
Jun 06, 2020
Adolescent inhalant use and psychosis risk - a prospective longitudinal study.
Antti Mustonen, Solja Niemelä, John J McGrath, Graham K Murray, Tanja Nordström, Pirjo Mäki, Jouko Miettunen, James G Scott
Nov 22, 2018
BACKGROUND: Cross-sectional studies have suggested inhalant use is associated with psychosis. This association was examined in a longitudinal study accounting for other substance use and potential confounders. METHODS: We used a...
Birth cohort Psychotic Disorders Schizophrenia Substance Abuse Adolescent Adolescent Behavior Adult Bipolar Disorder Comorbidity Depressive Disorder Major Family Follow-Up Studies Humans Incidence Inhalant Abuse Longitudinal Studies Mental Disorders Prospective Studies Psychotic Disorders Risk Factors Schizophrenia
Residual porosity of 3D-LAM-printed stainless-steel electrodes allows galvanic exchange platinisation
James Weber, Andrew J. Wain, Heidi Piili, Ville Pekka Matilainen, Anne Vuorema, Gary A. Attard, Frank Marken
Apr 27, 2016
Stainless-steel rods were manufactured by laser additive manufacturing (LAM or "3D-printing") from a stainless-steel (316L) powder precursor, and then investigated and compared to conventional stainless steel in...
Anomalous-Diffusion-Assisted Brightness in White Cellulose Nanofibril Membranes.
Matti S Toivonen, Olimpia D Onelli, Gianni Jacucci, Ville Lovikka, Orlando J Rojas, Olli Ikkala, Silvia Vignolini
Sep 27, 2018
The understanding of the interaction between light and complex, random structures is the key for designing and tailoring the optical appearance and performance of many materials that surround us, ranging from everyday consumer...
Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.
BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a...
AMP kinase Biguanide Metformin NADH:ubiquinone oxidoreductase Respiratory complex I Adenylate Kinase Animals Biguanides Cattle Cell Line Tumor Cell Membrane Permeability Cell Respiration Electron Transport Complex I Enzyme Activation Mice Mitochondria Mitochondrial Membranes Oxygen Consumption Phenformin Rats Rotenone Solubility
Perspectives on strengthening local food systems in Small Island Developing States.
Cornelia Guell, Catherine R Brown, Otto W Navunicagi, Viliamu Iese, Neela Badrie, Morgan Wairiu, Arlette Saint Ville, Nigel Unwin, Community Food and Health (CFaH) team
Jun 09, 2022
Small Island Developing States (SIDS) share high burdens of nutrition-related conditions, including non-communicable diseases, associated with an increasing reliance on imported, processed foods. Improving health through...
Perspectives on strengthening local food systems in Small Island Developing States.
Cornelia Guell, Catherine R Brown, Otto W Navunicagi, Viliamu Iese, Neela Badrie, Morgan Wairiu, Arlette Saint Ville, Nigel Unwin, Community Food and Health (CFaH) team
Oct 05, 2022
Small Island Developing States (SIDS) share high burdens of nutrition-related conditions, including non-communicable diseases, associated with an increasing reliance on imported, processed foods. Improving health through...
Improved EEG source localization with Bayesian uncertainty modelling of unknown skull conductivity
Electroencephalography (EEG) source imaging is an ill-posed inverse problem that requires accurate conductivity modelling of the head tissues, especially the skull. Unfortunately, the conductivity values are difficult to...
Laparoscopic adhesiolysis
Salomone Di Saverio, Arianna Birindelli, Richard Ten Broek, Justin R Davies, Matteo Mandrioli, Ville Sallinen
May 08, 2018
ASBO is a common cause of emergency surgery and the use of laparoscopy for the treatment of these patients is still under debate and conflicting results have been published, in particular regarding the high risk of iatrogenic...
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