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How infectious diseases arrived in the colonial Americas.
Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.
human Genetics Virus microbiology HBV infectious disease Genomics Africa paleovirology b19v paleogenomics Ancient Viruses Humans Communicable Diseases Americas Mexico
Published by: eLife
How infectious diseases arrived in the colonial Americas.
Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.
Residual porosity of 3D-LAM-printed stainless-steel electrodes allows galvanic exchange platinisation
James Weber, Andrew J. Wain, Heidi Piili, Ville Pekka Matilainen, Anne Vuorema, Gary A. Attard, Frank Marken
Apr 27, 2016
Stainless-steel rods were manufactured by laser additive manufacturing (LAM or "3D-printing") from a stainless-steel (316L) powder precursor, and then investigated and compared to conventional stainless steel in...
Using Group Model Building to Describe the System Driving Unhealthy Eating and Identify Intervention Points
Leonor Guariguata, Etiënne Aja Rouwette, Madhuvanti M Murphy, Arlette Saint Ville, Leith L Dunn, Gordon M Hickey, Waneisha Jones, T Alafia Samuels, Nigel Unwin
Jan 17, 2020
Many Small Island Developing States of the Caribbean experience a triple burden of malnutrition with high rates of obesity, undernutrition in children, and iron deficiency anemia in women of reproductive age, driven by an...
Caribbean NCDs agricultural development food sovereignty group model building small islands Systems science unhealthy diet Adolescent Caribbean Region Child Child Nutrition Disorders Child Preschool Diet Feeding Behavior Female Humans Jamaica Male Nutrition Policy Policy Making Saint Kitts and Nevis Saint Vincent and the Grenadines stakeholder participation Systems Analysis Young Adult
Classification of degenerative parkinsonism subtypes by support-vector-machine analysis and striatal 123I-FP-CIT indices.
Nicolas Nicastro, Jennifer Wegrzyk, Maria Giulia Preti, Vanessa Fleury, Dimitri Van de Ville, Valentina Garibotto, Pierre R Burkhard
Apr 26, 2019
OBJECTIVES: To provide an automated classification method for degenerative parkinsonian syndromes (PS) based on semiquantitative 123I-FP-CIT SPECT striatal indices and support-vector-machine (SVM) analysis. METHODS: 123I-FP-CIT...
Using Group Model Building to Describe the System Driving Unhealthy Eating and Identify Intervention Points
Many Small Island Developing States of the Caribbean experience a triple burden of malnutrition with high rates of obesity, undernutrition in children, and iron deficiency anemia in women of reproductive age, driven by an...
Evaluating genetic drift in time-series evolutionary analysis.
The Wright-Fisher model is the most popular population model for describing the behaviour of evolutionary systems with a finite population size. Approximations have commonly been used but the model itself has rarely been tested...
A method to infer positive selection from marker dynamics in an asexual population.
MOTIVATION: The observation of positive selection acting on a mutant indicates that the corresponding mutation has some form of functional relevance. Determining the fitness effects of mutations thus has relevance to many...
How infectious diseases arrived in the colonial Americas
Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.
Improved EEG source localization with Bayesian uncertainty modelling of unknown skull conductivity
Electroencephalography (EEG) source imaging is an ill-posed inverse problem that requires accurate conductivity modelling of the head tissues, especially the skull. Unfortunately, the conductivity values are difficult to...
A Combined Theory of Change-Group Model Building Approach to Evaluating “Farm to Fork” Models for School Feeding in the Caribbean
There is a scarcity of research on building nutrition-sensitive value chains (NSVCs) to improve diets and nutrition outcomes of populations in the Caribbean. This study contributes to filling this research gap by...
Effect of natural weathering on water absorption and pore size distribution in thermally modified wood determined by nuclear magnetic resonance
Chenyang Cai, Muhammad Asadullah Javed, Sanna Komulainen, Ville-Veikko Telkki, Antti Haapala, Henrik Heräjärvi
Jun 06, 2020
Residual porosity of 3D-LAM-printed stainless-steel electrodes allows galvanic exchange platinisation
James Weber, Andrew J. Wain, Heidi Piili, Ville Pekka Matilainen, Anne Vuorema, Gary A. Attard, Frank Marken
Apr 27, 2016
Stainless-steel rods were manufactured by laser additive manufacturing (LAM or "3D-printing") from a stainless-steel (316L) powder precursor, and then investigated and compared to conventional stainless steel in...
Anomalous-Diffusion-Assisted Brightness in White Cellulose Nanofibril Membranes.
Matti S Toivonen, Olimpia D Onelli, Gianni Jacucci, Ville Lovikka, Orlando J Rojas, Olli Ikkala, Silvia Vignolini
Sep 27, 2018
The understanding of the interaction between light and complex, random structures is the key for designing and tailoring the optical appearance and performance of many materials that surround us, ranging from everyday consumer...
Molecular features of biguanides required for targeting of mitochondrial respiratory complex I and activation of AMP-kinase.
BACKGROUND: The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a...
AMP kinase Biguanide Metformin NADH:ubiquinone oxidoreductase Respiratory complex I Adenylate Kinase Animals Biguanides Cattle Cell Line Tumor Cell Membrane Permeability Cell Respiration Electron Transport Complex I Enzyme Activation Mice Mitochondria Mitochondrial Membranes Oxygen Consumption Phenformin Rats Rotenone Solubility
Perspectives on strengthening local food systems in Small Island Developing States.
Cornelia Guell, Catherine R Brown, Otto W Navunicagi, Viliamu Iese, Neela Badrie, Morgan Wairiu, Arlette Saint Ville, Nigel Unwin, Community Food and Health (CFaH) team
Jun 09, 2022
Small Island Developing States (SIDS) share high burdens of nutrition-related conditions, including non-communicable diseases, associated with an increasing reliance on imported, processed foods. Improving health through...
Perspectives on strengthening local food systems in Small Island Developing States.
Cornelia Guell, Catherine R Brown, Otto W Navunicagi, Viliamu Iese, Neela Badrie, Morgan Wairiu, Arlette Saint Ville, Nigel Unwin, Community Food and Health (CFaH) team
Oct 05, 2022
Small Island Developing States (SIDS) share high burdens of nutrition-related conditions, including non-communicable diseases, associated with an increasing reliance on imported, processed foods. Improving health through...
Improved EEG source localization with Bayesian uncertainty modelling of unknown skull conductivity
Electroencephalography (EEG) source imaging is an ill-posed inverse problem that requires accurate conductivity modelling of the head tissues, especially the skull. Unfortunately, the conductivity values are difficult to...
Laparoscopic adhesiolysis
Salomone Di Saverio, Arianna Birindelli, Richard Ten Broek, Justin R Davies, Matteo Mandrioli, Ville Sallinen
May 08, 2018
ASBO is a common cause of emergency surgery and the use of laparoscopy for the treatment of these patients is still under debate and conflicting results have been published, in particular regarding the high risk of iatrogenic...
Genetic Evidence for Protective Effects of Angiotensin-Converting Enzyme Against Alzheimer Disease But Not Other Neurodegenerative Diseases in European Populations.
David K Ryan, Ville Karhunen, Bowen Su, Matthew Traylor, Tom G Richardson, Stephen Burgess, Ioanna Tzoulaki, Dipender Gill
Oct 01, 2022
BACKGROUND AND OBJECTIVES: Angiotensin-converting enzyme (ACE) inhibitors are a commonly prescribed class of medication used to treat heart failure, hypertension, and chronic kidney disease. However, previous observational...
Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk
Dipender Gill, Marios K Georgakis, Verena Zuber, Ville Karhunen, Stephen Burgess, Rainer Malik, Martin Dichgans
Jun 02, 2020
Background Elevated blood pressure is a major cause of cardiovascular morbidity and mortality. However, it is not known whether midlife blood pressure affects later life cardiovascular risk independent of later life blood...
Suppression of enteroendocrine cell glucagon-like peptide (GLP)-1 release by fat-induced small intestinal ketogenesis
Ville Wallenius, Erik Elias, Erik Elebring, Bauke Haisma, Anna Casselbrant, Pierre Larraufie, Emma Spak, Frank Reimann, Carel W le Roux, Neil G Docherty, Fiona M Gribble, Lars Fändriks
Nov 13, 2019
Diabetes mellitus enterocyte biology glucagen-like peptides obesity surgery small bowel 3-Hydroxybutyric Acid Anastomosis Roux-en-Y Animals Caloric Restriction Cells Cultured Dietary Fats Emulsions Enteroendocrine Cells Fat Emulsions Intravenous Female Gastric Bypass Glucagon-Like Peptide 1 Humans Hydroxymethylglutaryl-CoA Synthase Intestinal Mucosa Jejunum ketone bodies Ketones Liver Male Mice Mice Inbred C57BL Middle Aged Phospholipids Postoperative Period Preoperative Period Primary Cell Culture Soybean Oil
PET Reconstruction With an Anatomical MRI Prior Using Parallel Level Sets.
Matthias J Ehrhardt, Pawel Markiewicz, Maria Liljeroth, Anna Barnes, Ville Kolehmainen, John S Duncan, Luis Pizarro, David Atkinson, Brian F Hutton, Sebastien Ourselin, Kris Thielemans, Simon R Arridge
May 10, 2016
Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes
Dipender Gill, Verena Zuber, Jesse Dawson, Jonathan Pearson-Stuttard, Alice R. Carter, Eleanor Sanderson, Ville Karhunen, Michael G. Levin, Robyn E. Wootton, Derek Klarin, Philip S. Tsao, Konstantinos K. Tsilidis, Scott M. Damrauer, Stephen Burgess, Paul Elliott
Jun 28, 2021
Abstract: Background: Higher body mass index (BMI) and waist-to-hip ratio (WHR) increase the risk of cardiovascular disease, but the extent to which this is mediated by blood pressure, diabetes, lipid traits, and smoking is not...
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