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Results: 4512
Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients.
Hoang NH Tran, Trang Nguyen Hoang Thu, Phu Huu Nguyen, Chi Nguyen Vo, Khanh Van Doan, Chau Nguyen Ngoc Minh, Ngoc Tuan Nguyen, Van Ngoc Duc Ta, Khuong An Vu, Thanh Danh Hua, To Nguyen Thi Nguyen, Tan Trinh Van, Trung Pham Duc, Ba Lap Duong, Phuc Minh Nguyen, Vinh Chuc Hoang, Duy Thanh Pham, Guy E Thwaites, Lindsay J Hall, Daniel J Slade, Stephen Baker, Vinh Hung Tran, Hao Chung The
Nov 28, 2022
Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker. Despite its significance in the promotion of...
The Control of Typhoid Fever in Vietnam.
Tran Vu Thieu Nga, Pham Thanh Duy, Nguyen Phu Huong Lan, Nguyen Van Vinh Chau, Stephen Baker
Apr 10, 2019
Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), is a diminishing public health problem in Vietnam, and this process may represent a prototype for typhoid elimination in Asia. Here, we review typhoid...
Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam.
Hannah E Brindle, Behzad Nadjm, Marc Choisy, Rob Christley, Michael Griffiths, Stephen Baker, Juliet E Bryant, James I Campbell, Van Vinh Chau Nguyen, Thi Ngoc Diep Nguyen, Ty Thi Hang Vu, Van Hung Nguyen, Bao Long Hoang, Xuan Luat Le, Ha My Pham, Thi Dieu Ngan Ta, Dang Trung Nghia Ho, Thua Nguyen Tran, Thi Han Ny Nguyen, My Phuc Tran, Thi Hong Phuong Pham, Van Tan Le, Dac Thuan Nguyen, Thi Thu Trang Hau, Ngoc Vinh Nguyen, Heiman FL Wertheim, Guy E Thwaites, H Rogier van Doorn, VIZIONS consortium
Nov 16, 2022
An estimated 73% of emerging infections are zoonotic in origin, with animal contact and encroachment on their habitats increasing the risk of spill-over events. In Vietnam, close exposure to a wide range of animals and animal...
Viral Metagenomic Analysis of Cerebrospinal Fluid from Patients with Acute Central Nervous System Infections of Unknown Origin, Vietnam.
Nguyen To Anh, Le Nguyen Truc Nhu, Nguyen Thi Thu Hong, Tran My Phuc, Pham Thi Thanh Tam, Dang Thao Huong, Tran Tuan Anh, Xutao Deng, Ho Dang Trung Nghia, Tran Thua Nguyen, Nguyen Van Hung, Nguyen Dac Thuan, Pham Thi Hong Phuong, Nguyen Van Vinh Chau, Stephen Baker, Eric Delwart, Guy Thwaites, Le Van Tan, VIZIONS Consortium1
May 17, 2021
Central nervous system (CNS) infection is a serious neurologic condition, although the etiology remains unknown in >50% of patients. We used metagenomic next-generation sequencing to detect viruses in 204 cerebrospinal fluid...
C-reactive protein as a potential biomarker for disease progression in dengue
Nguyen Lam Vuong, Huynh Thi Le Duyen, Phung Khanh Lam, Dong Thi Hoai Tam, Nguyen Van Vinh Chau, Nguyen Van Kinh, Ngoun Chanpheaktra, Lucy Chai See Lum, Ernesto Pleités, Nick Keith Jones, Cameron Paul Simmons, Kerstin Rosenberger, Thomas Jaenisch, Christine Halleux, Piero Luigi Olliaro, Bridget Wills, Sophie Yacoub
Mar 25, 2020
BACKGROUND:Dengue infection can cause a wide spectrum of clinical outcomes. The severe clinical manifestations occur sufficiently late in the disease course, during day 4-6 of illness, to allow a window of opportunity for risk...
Published by: BMC medicine
Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients.
Hoang NH Tran, Trang Nguyen Hoang Thu, Phu Huu Nguyen, Chi Nguyen Vo, Khanh Van Doan, Chau Nguyen Ngoc Minh, Ngoc Tuan Nguyen, Van Ngoc Duc Ta, Khuong An Vu, Thanh Danh Hua, To Nguyen Thi Nguyen, Tan Trinh Van, Trung Pham Duc, Ba Lap Duong, Phuc Minh Nguyen, Vinh Chuc Hoang, Duy Thanh Pham, Guy E Thwaites, Lindsay J Hall, Daniel J Slade, Stephen Baker, Vinh Hung Tran, Hao Chung The
Oct 29, 2022
Perturbations in the gut microbiome have been associated with colorectal cancer (CRC), with the colonic overabundance of Fusobacterium nucleatum shown as the most consistent marker. Despite its significance in the promotion of...
Hospital-acquired colonization and infections in a Vietnamese intensive care unit.
Duong Bich Thuy, James Campbell, Le Thanh Hoang Nhat, Nguyen Van Minh Hoang, Nguyen Van Hao, Stephen Baker, Ronald B Geskus, Guy E Thwaites, Nguyen Van Vinh Chau, C Louise Thwaites
Apr 10, 2019
Data concerning intensive care unit (ICU)-acquired bacterial colonization and infections are scarce from low and middle-income countries (LMICs). ICU patients in these settings are at high risk of becoming colonized and infected...
Aetiology and Potential Animal Exposure in Central Nervous System Infections in Vietnam.
Hannah E Brindle, Behzad Nadjm, Marc Choisy, Rob Christley, Michael Griffiths, Stephen Baker, Juliet E Bryant, James I Campbell, Van Vinh Chau Nguyen, Thi Ngoc Diep Nguyen, Ty Thi Hang Vu, Van Hung Nguyen, Bao Long Hoang, Xuan Luat Le, Ha My Pham, Thi Dieu Ngan Ta, Dang Trung Nghia Ho, Thua Nguyen Tran, Thi Han Ny Nguyen, My Phuc Tran, Thi Hong Phuong Pham, Van Tan Le, Dac Thuan Nguyen, Thi Thu Trang Hau, Ngoc Vinh Nguyen, Heiman FL Wertheim, Guy E Thwaites, H Rogier van Doorn, VIZIONS consortium
Feb 03, 2023
An estimated 73% of emerging infections are zoonotic in origin, with animal contact and encroachment on their habitats increasing the risk of spill-over events. In Vietnam, close exposure to a wide range of animals and animal...
Retrospective analysis assessing the spatial and temporal distribution of paediatric acute respiratory tract infections in Ho Chi Minh City, Vietnam.
Nhan Thi Ho, Corinne Thompson, Le Nguyen Thanh Nhan, Hoang Minh Tu Van, Nguyen Thanh Dung, Phuc Tran My, Vo Minh Quang, Ngo Ngoc Quang Minh, Tran Anh Tuan, Nguyen Thanh Hung, Ha Manh Tuan, Nguyen Van Vinh Chau, Marcel Wolbers, Guy E Thwaites, Marc Choisy, Stephen Baker
Apr 10, 2019
BACKGROUND: Acute respiratory tract infections (ARIs) are the leading cause of morbidity and mortality in young children in low/middle-income countries. Using routine hospital data, we aimed to examine the spatial distribution...
acute respiratory infections lower respiratory infections Pediatrics spatial distribution Temporal patterns upper respiratory infections Acute Disease Adolescent Child Child Preschool Female Hospitalization Hospitals Pediatric Humans Incidence Infant Infant Newborn Male Respiratory Tract Infections Retrospective Studies Risk Factors Seasons Spatio-Temporal Analysis Vietnam weather
Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia.
Kelly L Wyres, To N T Nguyen, Margaret M C Lam, Louise M Judd, Nguyen Van Vinh Chau, David A B Dance, Margaret Ip, Abhilasha Karkey, Clare L Ling, Thyl Miliya, Paul N Newton, Nguyen Phu Huong Lan, Amphone Sengduangphachanh, Paul Turner, Balaji Veeraraghavan, Phat Voong Vinh, Manivanh Vongsouvath, Nicholas R Thomson, Stephen Baker, Kathryn E Holt
Feb 19, 2020
BACKGROUND:Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI). Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new treatment...
Published by: Genome medicine
C-reactive protein as a potential biomarker for disease progression in dengue
Nguyen Lam Vuong, Huynh Thi Le Duyen, Phung Khanh Lam, Dong Thi Hoai Tam, Nguyen Van Vinh Chau, Nguyen Van Kinh, Ngoun Chanpheaktra, Lucy Chai See Lum, Ernesto Pleités, Nick Keith Jones, Cameron Paul Simmons, Kerstin Rosenberger, Thomas Jaenisch, Christine Halleux, Piero Luigi Olliaro, Bridget Wills, Sophie Yacoub
Feb 16, 2021
BACKGROUND: Dengue infection can cause a wide spectrum of clinical outcomes. The severe clinical manifestations occur sufficiently late in the disease course, during day 4-6 of illness, to allow a window of opportunity for risk...
Factors associated with a low prevalence of exclusive breastfeeding during hospital stay in urban and semi-rural areas of southern Vietnam.
Quynh-Nhi Thi Le, Khanh-Lam Phung, Van-Thuy Thi Nguyen, Katherine L Anders, Minh-Nguyet Nguyen, Diem-Tuyet Thi Hoang, Thuy-Tien Thi Bui, Vinh-Chau Van Nguyen, Guy E Thwaites, Cameron Simmons, Stephen Baker
Apr 10, 2019
BACKGROUND: There is a paucity of data regarding risk factors associated with suboptimal breastfeeding practices in urbanized areas of low-middle income countries (LMICs). METHODS: Through a large prospective birth cohort, which...
C-reactive protein as a potential biomarker for disease progression in dengue
Nguyen Lam Vuong, Huynh Thi Le Duyen, Phung Khanh Lam, Dong Thi Hoai Tam, Nguyen Van Vinh Chau, Nguyen Van Kinh, Ngoun Chanpheaktra, Lucy Chai See Lum, Ernesto Pleités, Nick Keith Jones, Cameron Paul Simmons, Kerstin Rosenberger, Thomas Jaenisch, Christine Halleux, Piero Luigi Olliaro, Bridget Wills, Sophie Yacoub
Jun 06, 2020
Abstract: Background: Dengue infection can cause a wide spectrum of clinical outcomes. The severe clinical manifestations occur sufficiently late in the disease course, during day 4–6 of illness, to allow a window of opportunity...
Comparative genomics of Cryptococcus neoformans var. grubii associated with meningitis in HIV infected and uninfected patients in Vietnam.
Jeremy N Day, Seet Qihui, Lam Tuan Thanh, Phan Hai Trieu, Anh Duong Van, Nha Hoang Thu, Tran Thi Hong Chau, Nguyen PH Lan, Nguyen Van Vinh Chau, Philip M Ashton, Guy E Thwaites, Maciej F Boni, Marcel Wolbers, Niranjan Nagarajan, Patrick BO Tan, Stephen Baker
Apr 10, 2019
The vast burden of cryptococcal meningitis occurs in immunosuppressed patients, driven by HIV, and is caused by Cryptococcus neoformans var. grubii. We previously reported cryptococcal meningitis in Vietnam arising atypically in...
A Double-blind, Randomized, Placebo-controlled Trial of Lactobacillus acidophilus for the Treatment of Acute Watery Diarrhea in Vietnamese Children.
Tran Thi Hong Chau, Nguyen Ngoc Minh Chau, Nhat Thanh Hoang Le, Hao Chung The, Phat Voong Vinh, Nguyen Thi Nguyen To, Nguyen Minh Ngoc, Ha Manh Tuan, Tang Le Chau Ngoc, Marion-Eliette Kolader, Jeremy J Farrar, Marcel Wolbers, Guy E Thwaites, Stephen Baker, Oxford-Vietnam Probiotics Study Group
Aug 02, 2019
Invasive Non-typhoidal Salmonella Infections in Asia
Nguyen Phu Huong Lan, Tu Le Thi Phuong, Hien Nguyen Huu, Le Thuy, Alison E Mather, Se Eun Park, Florian Marks, Guy E Thwaites, Nguyen Van Vinh Chau, Corinne N Thompson, Stephen Baker
Feb 19, 2019
Invasive non-typhoidal Salmonella (iNTS) infections are now a well-described cause of morbidity and mortality in children and HIV-infected adults in sub-Saharan Africa. In contrast, the epidemiology and clinical manifestations...
Adult Aged Anti-Infective Agents Ceftriaxone Drug Therapy Combination Female Fluoroquinolones HIV Infections Hospitals Humans Logistic Models Male Middle Aged Multilocus Sequence Typing Multivariate Analysis Retrospective Studies Salmonella Infections Salmonella enterica Serogroup Sex Factors Trimethoprim Sulfamethoxazole Drug Combination Typhoid Fever Vietnam
A randomised controlled trial of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDITOF-MS) versus conventional microbiological methods for identifying pathogens
Behzad Nadjm, Vu Quoc Dat, James I Campbell, Vu Tien Viet Dung, Alessandro Torre, Nguyen Thi Cam Tu, Ninh Thi Thanh Van, Dao Tuyet Trinh, Nguyen Phu Huong Lan, Nguyen Vu Trung, Nguyen Thi Thuy Hang, Le Thi Hoi, Stephen Baker, Marcel Wolbers, Nguyen Van Vinh Chau, Nguyen Van Kinh, Guy E Thwaites, H Rogier van Doorn, Heiman FL Wertheim
Apr 18, 2019
OBJECTIVES: We assessed the impact of MALDITOF-MS on the timeliness of optimal antimicrobial therapy through a parallel-arm randomised controlled trial in two hospitals in Vietnam. METHODS: We recruited patients with a pathogen...
antibacterial agents bacteraemia Matrix-assisted laser desorption-ionization mass spectrometry Microbiological Techniques Vietnam Adult Anti-Bacterial Agents Antifungal Agents Bacteremia Bacteria Female fungi Humans Male Microbiological Techniques Middle Aged Mycoses Prospective Studies Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Time Factors Treatment Outcome Vietnam
Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia.
Kelly L Wyres, To NT Nguyen, Margaret MC Lam, Louise M Judd, Nguyen Van Vinh Chau, David AB Dance, Margaret Ip, Abhilasha Karkey, Clare L Ling, Thyl Miliya, Paul N Newton, Nguyen Phu Huong Lan, Amphone Sengduangphachanh, Paul Turner, Balaji Veeraraghavan, Phat Voong Vinh, Manivanh Vongsouvath, Nicholas R Thomson, Stephen Baker, Kathryn E Holt
Mar 02, 2020
BACKGROUND: Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI). Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new treatment...
Structure of general-population antibody titer distributions to influenza A virus.
Nguyen Thi Duy Nhat, Stacy Todd, Erwin de Bruin, Tran Thi Nhu Thao, Nguyen Ha Thao Vy, Tran Minh Quan, Dao Nguyen Vinh, Janko van Beek, Pham Hong Anh, Ha Minh Lam, Nguyen Thanh Hung, Nguyen Thi Le Thanh, Huynh Le Anh Huy, Vo Thi Hong Ha, Stephen Baker, Guy E Thwaites, Nguyen Thi Nam Lien, Tran Thi Kim Hong, Jeremy Farrar, Cameron P Simmons, Nguyen Van Vinh Chau, Marion Koopmans, Maciej F Boni
Apr 10, 2019
Seroepidemiological studies aim to understand population-level exposure and immunity to infectious diseases. Their results are normally presented as binary outcomes describing the presence or absence of pathogen-specific...
Current challenges and possible solutions to improve access to care and treatment for hepatitis C infection in Vietnam
Alessandra Berto, Jeremy Day, Nguyen Van Vinh Chau, Guy E Thwaites, Ngoc Nghiem My, Stephen Baker, Thomas C Darton
Apr 10, 2019
BACKGROUND: Hepatitis C infection is a major public health concern in low- and middle-income countries where an estimated 71.1 million individuals are living with chronic infection. The World Health Organization (WHO) has...
The Role of Maternally Acquired Antibody in Providing Protective Immunity Against Nontyphoidal Salmonella in Urban Vietnamese Infants
Ruklanthi de Alwis, Le Thi Phuong Tu, Nhi Le Thi Quynh, Corinne N Thompson, Katherine L Anders, Nguyen Thi Van Thuy, Nguyen Trong Hieu, Lu Lan Vi, Nguyen Van Vinh Chau, Vu Thuy Duong, Tran Thi Hong Chau, Ha Thanh Tuyen, Tran Vu Thieu Nga, Pham Van Minh, Trinh Van Tan, Trang Nguyen Hoang Thu, Tran Do Hoang Nhu, Guy E Thwaites, Cameron Simmons, Stephen Baker
Apr 09, 2019
BACKGROUND: Nontyphoidal Salmonella (NTS) organisms are a major cause of gastroenteritis and bacteremia, but little is known about maternally acquired immunity and natural exposure in infant populations residing in areas where...
Differential prevalence and geographic distribution of hepatitis C virus genotypes in acute and chronic hepatitis C patients in Vietnam.
Chau Le Ngoc, Thanh Tran Thi Thanh, Phuong Tran Thi Lan, Trinh Nguyen Mai, Trang Nguyen Hoa, Ngoc Nghiem My, Tan Le Van, Hung Le Manh, Phuong Le Thanh, Chau Nguyen Van Vinh, Guy Thwaites, Graham Cooke, Gabrielle M Heilek, Cecilia Shikuma, Thuy Le, Stephen Baker, Motiur Rahman, VIZIONS consortium
Apr 10, 2019
BACKGROUND: The highest burden of disease from hepatitis C virus (HCV) is found in Southeast Asia, but our understanding of the epidemiology of infection in many heavily burdened countries is still limited. In particular, there...
Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia
Kelly L. Wyres, To N. T. Nguyen, Margaret M. C. Lam, Louise M. Judd, Nguyen Van Vinh Chau, David A. B. Dance, Margaret Ip, Abhilasha Karkey, Clare L. Ling, Thyl Miliya, Paul N. Newton, Nguyen Phu Huong Lan, Amphone Sengduangphachanh, Paul Turner, Balaji Veeraraghavan, Phat Voong Vinh, Manivanh Vongsouvath, Nicholas R. Thomson, Stephen Baker, Kathryn E. Holt
Jan 15, 2021
Abstract: Background: Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI). Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new...
Prognostic models for 9 month mortality in tuberculous meningitis
Le Thi Phuong Thao, A Dorothee Heemskerk, Ronald B Geskus, Nguyen Thi Hoang Mai, Dang Thi Minh Ha, Tran Thi Hong Chau, Nguyen Hoan Phu, Nguyen Van Vinh Chau, Maxine Caws, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Thuy Thuong Thuong, Jeremy Day, Jeremy J Farrar, M Estee Torok, Nguyen Duc Bang, Guy E Thwaites, Marcel Wolbers
May 02, 2018
Genomic surveillance for hypervirulence and multi-drug resistance in invasive Klebsiella pneumoniae from South and Southeast Asia
Kelly L. Wyres, To N. T. Nguyen, Margaret M. C. Lam, Louise M. Judd, Nguyen Van Vinh Chau, David A. B. Dance, Margaret Ip, Abhilasha Karkey, Clare L. Ling, Thyl Miliya, Paul N. Newton, Nguyen Phu Huong Lan, Amphone Sengduangphachanh, Paul Turner, Balaji Veeraraghavan, Phat Voong Vinh, Manivanh Vongsouvath, Nicholas R. Thomson, Stephen Baker, Kathryn E. Holt
Jun 06, 2020
Abstract: Background: Klebsiella pneumoniae is a leading cause of bloodstream infection (BSI). Strains producing extended-spectrum beta-lactamases (ESBLs) or carbapenemases are considered global priority pathogens for which new...
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