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MiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer.
Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio
Nov 25, 2022
The telomeric repeat-binding factor 2 (TRF2) is a telomere-capping protein that plays a key role in the maintenance of telomere structure and function. It is highly expressed in different cancer types, and it contributes to...
Apobec1-Mediated RNA Editing in Monocytes Contributes to Genetic Heterogeneity and Modulates Monocyte Activity and Development
Violeta Rayón Estrada
Jan 01, 0001
Post-transcriptional modifications such as alternative splicing have been shown to add to the complexity needed to compensate for the relatively low number of genes found in higher organisms. Many other modifications recently...
Published by: Rockefeller University
Optimal searching behaviour generated intrinsically by the central pattern generator for locomotion.
Efficient searching for resources such as food by animals is key to their survival. It has been proposed that diverse animals from insects to sharks and humans adopt searching patterns that resemble a simple Lévy random walk...
D. melanogaster central pattern generator Ecology Exploration levy walk Locomotion neuroscience Animals Apoptosis Appetitive Behavior Brain Central pattern generators Cues Drosophila Proteins Drosophila melanogaster Dynamins Exploratory Behavior Feeding Behavior Larva Locomotion Probability Temperature
Genetics of Gland-in-situ or Hypoplastic Congenital Hypothyroidism in Macedonia.
Nikolina Zdraveska, Mirjana Kocova, Adeline K Nicholas, Violeta Anastasovska, Nadia Schoenmakers
May 27, 2020
congenital hypothyroidism dyshormonogenesis Genes Goiter Iodine screening thyroid hypoplasia Child Child Preschool congenital hypothyroidism High-Throughput Nucleotide Sequencing Humans Infant Infant Newborn Mutation PAX8 Transcription Factor Phenotype Receptors Thyrotropin Republic of North Macedonia Thyroid Dysgenesis
Heteropolynuclear Pt(II)–M(I) clusters with a C∧N∧C biscyclometalated ligand
The mononuclear complex [(EtO2C-CNC)Pt(dmpyz)] (1) (dmpyz = 2,5-dimethylpyrazine) has been synthesized by reaction of [(EtO2C-CNC)Pt(dmso)] (A) with dmpyz in a 1:1 molar ratio in dichloromethane. Complex 1 is the precursor for...
Ion-Pair-Directed Borylation of Aromatic Phosphonium Salts.
Control of positional selectivity in C-H activation reactions remains a challenge for synthetic chemists. Noncovalent catalysis has the potential to be a powerful strategy to address this challenge. As a part of our ongoing...
Genetics of Gland- in-situ or Hypoplastic Congenital Hypothyroidism in Macedonia
Nikolina Zdraveska, Mirjana Kocova, Adeline K. Nicholas, Violeta Anastasovska, Nadia Schoenmakers
Jul 28, 2020
Neonatal screening in Macedonia detects congenital hypothyroidism (CH) with an incidence of 1 in 1,585, and more than 50% of cases exhibit a normally located gland-in-situ (GIS). Monogenic mutations causing dyshormonogenesis may...
Heteropolynuclear Pt(II)–M(I) clusters with a C∧N∧C biscyclometalated ligand
The mononuclear complex [(EtO2C-CNC)Pt(dmpyz)] (1) (dmpyz = 2,5-dimethylpyrazine) has been synthesized by reaction of [(EtO2C-CNC)Pt(dmso)] (A) with dmpyz in a 1:1 molar ratio in dichloromethane. Complex 1 is the precursor for...
Plant cell divisions
In plants, the spatial arrangement of cells within tissues and organs is a direct consequence of the positioning of the new cell walls during cell division. Since the nineteenth century, scientists have proposed rules to explain...
cellular reproduction developmental biology plant biology Arabidopsis Cell Division Cell Nucleus Cell Polarity Cell Proliferation Cell Shape Cell Wall Gene Expression Regulation Plant Hormones Indoleacetic Acids Microtubules Models Biological Plant Cells Plant Physiological Phenomena Signal Transduction Stress Mechanical
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.
Dimitra Georgopoulou, Maurizio Callari, Oscar M Rueda, Abigail Shea, Alistair Martin, Agnese Giovannetti, Fatime Qosaj, Ali Dariush, Suet-Feung Chin, Larissa S Carnevalli, Elena Provenzano, Wendy Greenwood, Giulia Lerda, Elham Esmaeilishirazifard, Martin O'Reilly, Violeta Serra, Dario Bressan, IMAXT Consortium, Gordon B Mills, H Raza Ali, Sabina S Cosulich, Gregory J Hannon, Alejandra Bruna, Carlos Caldas
Mar 04, 2021
The heterogeneity of breast cancer plays a major role in drug response and resistance and has been extensively characterized at the genomic level. Here, a single-cell breast cancer mass cytometry (BCMC) panel is optimized to...
An order restricted multi-arm multi-stage clinical trial design.
One family of designs that can noticeably improve efficiency in later stages of drug development are multi-arm multi-stage (MAMS) designs. They allow several arms to be studied concurrently and gain efficiency by dropping poorly...
Interhomolog polymorphism shapes meiotic crossover within the Arabidopsis RAC1 and RPP13 disease resistance genes.
Heïdi Serra, Kyuha Choi, Xiaohui Zhao, Alexander R Blackwell, Juhyun Kim, Ian R Henderson
Jan 02, 2019
Network equilibration and first-principles liquid water.
Motivated by the very low diffusivity recently found in ab initio simulations of liquid water, we have studied its dependence with temperature, system size, and duration of the simulations. We use ab initio molecular dynamics...
Room temperature compressibility and diffusivity of liquid water from first principles.
The isothermal compressibility of water is essential to understand its anomalous properties. We compute it by ab initio molecular dynamics simulations of 200 molecules at five densities, using two different van der Waals density...
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RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display...
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells.
Harveer Dev, Ting-Wei Will Chiang, Chloe Lescale, Inge de Krijger, Alistair G Martin, Domenic Pilger, Julia Coates, Matylda Sczaniecka-Clift, Wenming Wei, Matthias Ostermaier, Mareike Herzog, Jonathan Lam, Abigail Shea, Mukerrem Demir, Qian Wu, Fengtang Yang, Beiyuan Fu, Zhongwu Lai, Gabriel Balmus, Rimma Belotserkovskaya, Violeta Serra, Mark J O'Connor, Alejandra Bruna, Petra Beli, Luca Pellegrini, Carlos Caldas, Ludovic Deriano, Jacqueline JL Jacobs, Yaron Galanty, Stephen P Jackson
Sep 29, 2018
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome...
Animals BRCA1 Protein Bone Neoplasms Breast Neoplasms Cell Cycle Proteins Cell Line Tumor cisplatin DNA Breaks Double-Stranded DNA End-Joining Repair DNA-Binding Proteins Dose-Response Relationship Drug Drug Resistance Neoplasm Female HEK293 Cells Humans Mad2 Proteins Mice Multiprotein Complexes Osteosarcoma Ovarian Neoplasms Poly(ADP-ribose) Polymerase Inhibitors Proteins Recombinational DNA Repair Telomere-Binding Proteins Tumor Suppressor p53-Binding Protein 1 Xenograft Model Antitumor Assays
Optimal finite-range atomic basis sets for liquid water and ice.
Finite-range numerical atomic orbitals are the basis functions of choice for several first principles methods, due to their flexibility and scalability. Generating and testing such basis sets, however, remains a significant...
Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway.
Amparo Romero-Picó, Marta G Novelle, Omar Al-Massadi, Daniel Beiroa, Marta Tojo, Violeta Heras, Francisco Ruiz-Pino, Ana Senra, Miguel López, Clemence Blouet, Manuel Tena-Sempere, Rubén Nogueiras, Carlos Diéguez
Apr 24, 2022
Weight gain is a hallmark of decreased estradiol (E2) levels because of menopause or following surgical ovariectomy (OVX) at younger ages. Of note, this weight gain tends to be around the abdomen, which is frequently associated...
Ustekinumab and Vedolizumab Are Equally Safe and Effective in Elderly Crohn's Disease Patients.
Gerum Gashaw Gebeyehu, Joseph Fiske, Eleanor Liu, Jimmy K Limdi, Giacomo Broglio, Christian Selinger, Violeta Razsanskaite, Philip J Smith, Paul K Flanagan, Sreedhar Subramanian
Jan 04, 2023
BACKGROUND: Anti-tumour necrosis factor (anti-TNF) agents are associated with increased infection risk among elderly inflammatory bowel disease (IBD) patients, and thus, alternative biologics may be preferable. However, little...
Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway.
Amparo Romero-Picó, Marta G Novelle, Omar Al-Massadi, Daniel Beiroa, Marta Tojo, Violeta Heras, Francisco Ruiz-Pino, Ana Senra, Miguel López, Clemence Blouet, Manuel Tena-Sempere, Rubén Nogueiras, Carlos Diéguez
Jun 07, 2022
Weight gain is a hallmark of decreased estradiol (E2) levels because of menopause or following surgical ovariectomy (OVX) at younger ages. Of note, this weight gain tends to be around the abdomen, which is frequently associated...
Economic assessment of wild bird mortality induced by the use of lead gunshot in European wetlands.
Alessandro Andreotti, Vittorio Guberti, Riccardo Nardelli, Simone Pirrello, Lorenzo Serra, Stefano Volponi, Rhys E Green
Apr 26, 2018
In European wetlands, at least 40 bird species are exposed to the risk of lead poisoning caused by ingestion of spent lead gunshot. Adopting a methodology developed in North America, we estimated that about 700,000 individuals...
Easy Generation of Facial Animation Using Motion Graphs
Jose Figueiredo Serra, O Cetinaslan, Shridhar Ravikumar, Veronica Orvalho, Darren Cosker
Feb 01, 2018
Facial animation is a time-consuming and cumbersome task that requires years of experience and/or a complex and expensive set-up. This becomes an issue, especially when animating the multitude of secondary characters required...
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