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Results: 11551
VGEA
Paul E Oluniyi, Fehintola Ajogbasile, Judith Oguzie, Jessica Uwanibe, Adeyemi Kayode, Anise Happi, Alphonsus Ugwu, Testimony Olumade, Olusola Ogunsanya, Philomena Ehiaghe Eromon, Onikepe Folarin, Simon DW Frost, Jonathan Heeney, Christian T Happi
Nov 09, 2021
Next generation sequencing (NGS)-based studies have vastly increased our understanding of viral diversity. Viral sequence data obtained from NGS experiments are a rich source of information, these data can be used to study their...
Duration of Hybrid Closed-Loop Insulin Therapy to Achieve Representative Glycemic Outcomes in Adults With Type 1 Diabetes.
A Study of Prevalence of Intestinal Helminthic Infections and Associated Risk Factors among the Tea Estates workers of Ilam District, Eastern Region of Nepal
Introduction: Intestinal parasites are widely prevalent in developing countries, probably due to poor sanitation and inadequate personal hygiene. It is estimated that as much as 60% of the world’s population is infected with...
Published by: IJHS Medical Association
Viral infections in critical care
Viral infections form a substantial part of the intensive care workload, even before the recent and ongoing COVID-19 pandemic. The growing availability of molecular diagnostics for viral infections has led to increased...
A Study of Prevalence of Intestinal Helminthic Infections and Associated Risk Factors among the Tea Estates workers of Ilam District, Eastern Region of Nepal
Introduction: Intestinal parasites are widely prevalent in developing countries, probably due to poor sanitation and inadequate personal hygiene. It is estimated that as much as 60% of the world’s population is infected with...
Published by: IJHS Medical Association
Young Children Have Higher Variability of Insulin Requirements
Klemen Dovc, Charlotte Boughton, Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Carlo L Acerini, Sabine Arnolds, Carine de Beaufort, Richard M Bergenstal, Fiona Campbell, Amy Criego, David B Dunger, Daniella Elleri, Mark L Evans, Elke Fröhlich-Reiterer, Sabine Hofer, Thomas Kapellen, Lalantha Leelarathna, Thomas R Pieber, Birgit Rami-Merhar, Viral N Shah, Judy Sibayan, Malgorzata E Wilinska, Roman Hovorka, AP@Home, and KidsAP Consortia APCam11
Apr 30, 2019
OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young...
Adolescent Adult Age Factors Aged Blood Glucose Blood Glucose Self-Monitoring Child Child Preschool Cross-Over Studies Diabetes mellitus Type 1 Dose-Response Relationship Drug Female Humans Hypoglycemic Agents Individuality Infant Insulin Insulin Infusion Systems Male Middle Aged Multicenter Studies as Topic Randomized Controlled Trials as Topic Retrospective Studies Young Adult
Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time.
A Sarah Walker, Emma Pritchard, Thomas House, Julie V Robotham, Paul J Birrell, Iain Bell, John I Bell, John N Newton, Jeremy Farrar, Ian Diamond, Ruth Studley, Jodie Hay, Karina-Doris Vihta, Timothy EA Peto, Nicole Stoesser, Philippa C Matthews, David W Eyre, Koen B Pouwels, COVID-19 Infection Survey team
Oct 04, 2021
BACKGROUND: Information on SARS-CoV-2 in representative community surveillance is limited, particularly cycle threshold (Ct) values (a proxy for viral load). METHODS: We included all positive nose and throat swabs 26 April 2020...
The association between a detectable HIV viral load and non-communicable diseases comorbidity in HIV positive adults on antiretroviral therapy in Western Cape, South Africa.
BACKGROUND: Past studies have found a relationship between detectable HIV viral load and non-communicable diseases (NCDs) in HIV-infected individuals on antiretroviral therapy in high-income settings, however there is little...
Transgene codon usage drives viral fitness and therapeutic efficacy in oncolytic adenoviruses.
Estela Núñez-Manchón, Martí Farrera-Sal, Marc Otero-Mateo, Giancarlo Castellano, Rafael Moreno, David Medel, Ramon Alemany, Eneko Villanueva, Cristina Fillat
Aug 28, 2021
Arming oncolytic adenoviruses with therapeutic transgenes is a well-established strategy for multimodal tumour attack. However, this strategy sometimes leads to unexpected attenuated viral replication and a loss of oncolytic...
Modelling upper respiratory viral load dynamics of SARS-CoV-2.
Joseph D Challenger, Cher Y Foo, Yue Wu, Ada WC Yan, Mahdi Moradi Marjaneh, Felicity Liew, Ryan S Thwaites, Lucy C Okell, Aubrey J Cunnington
Jan 28, 2022
Relationships between viral load, severity of illness, and transmissibility of virus are fundamental to understanding pathogenesis and devising better therapeutic and prevention strategies for COVID-19. Here we present...
Modelling upper respiratory viral load dynamics of SARS-CoV-2.
Joseph D Challenger, Cher Y Foo, Yue Wu, Ada WC Yan, Mahdi Moradi Marjaneh, Felicity Liew, Ryan S Thwaites, Lucy C Okell, Aubrey J Cunnington
Feb 13, 2022
Relationships between viral load, severity of illness, and transmissibility of virus are fundamental to understanding pathogenesis and devising better therapeutic and prevention strategies for COVID-19. Here we present...
A Comparative Analysis of Deep Learning Approaches for Network Intrusion Detection Systems (N-IDSs)
Recently, due to the advance and impressive results of deep learning techniques in the fields of image recognition, natural language processing and speech recognition for various long-standing artificial intelligence (AI) tasks...
Published by: IGI Global Scientific Publishing
Exploiting Connections for Viral Replication.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 (coronavirus disease 2019) pandemic, is a positive strand RNA (+RNA) virus. Like other +RNA viruses, SARS-CoV-2 is dependent on host cell...
Viral dynamics of acute SARS-CoV-2 infection and applications to diagnostic and public health strategies.
Stephen M Kissler, Joseph R Fauver, Christina Mack, Scott W Olesen, Caroline Tai, Kristin Y Shiue, Chaney C Kalinich, Sarah Jednak, Isabel M Ott, Chantal BF Vogels, Jay Wohlgemuth, James Weisberger, John DiFiori, Deverick J Anderson, Jimmie Mancell, David D Ho, Nathan D Grubaugh, Yonatan H Grad
Sep 14, 2021
SARS-CoV-2 infections are characterized by viral proliferation and clearance phases and can be followed by low-level persistent viral RNA shedding. The dynamics of viral RNA concentration, particularly in the early stages of...
Exploiting Connections for Viral Replication
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 (coronavirus disease 2019) pandemic, is a positive strand RNA (+RNA) virus. Like other +RNA viruses, SARS-CoV-2 is dependent on host cell...
Superinfection exclusion
Viral superinfection occurs when multiple viral particles subsequently infect the same host. In nature, several viral species are found to have evolved diverse mechanisms to prevent superinfection (superinfection exclusion) but...
Closed-loop insulin delivery in suboptimally controlled type 1 diabetes
Martin Tauschmann, Hood Thabit, Lia Bally, Janet M Allen, Sara Hartnell, Malgorzata E Wilinska, Yue Ruan, Judy Sibayan, Craig Kollman, Peiyao Cheng, Roy W Beck, Carlo L Acerini, Mark L Evans, David B Dunger, Daniela Elleri, Fiona Campbell, Richard M Bergenstal, Amy Criego, Viral N Shah, Lalantha Leelarathna, Roman Hovorka, APCam11 Consortium
Sep 08, 2018
BACKGROUND: The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop insulin delivery compared with sensor-augmented pump...
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Jan 15, 2020
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins...
A swine arterivirus deubiquitinase stabilizes two major envelope proteins and promotes production of viral progeny.
Rui Guo, Xingyu Yan, Yanhua Li, Jin Cui, Saurav Misra, Andrew E Firth, Eric J Snijder, Ying Fang
Mar 18, 2021
Arteriviruses are enveloped positive-strand RNA viruses that assemble and egress using the host cell's exocytic pathway. In previous studies, we demonstrated that most arteriviruses use a unique -2 ribosomal frameshifting...
DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation.
The transcription factors IRF3 and NF-κB are crucial in innate immune signalling in response to many viral and bacterial pathogens. However, mechanisms leading to their activation remain incompletely understood. Viral RNA can be...
Mini viral RNAs act as innate immune agonists during influenza virus infection.
Aartjan JW Te Velthuis, Joshua C Long, David LV Bauer, Rebecca LY Fan, Hui-Ling Yen, Jane Sharps, Jurre Y Siegers, Marian J Killip, Hollie French, Maria José Oliva-Martín, Richard E Randall, Emmie de Wit, Debby van Riel, Leo LM Poon, Ervin Fodor
Sep 08, 2018
The molecular processes that determine the outcome of influenza virus infection in humans are multifactorial and involve a complex interplay between host, viral and bacterial factors1. However, it is generally accepted that a...
The neural basis of hot and cold cognition in depressed patients, unaffected relatives, and low-risk healthy controls
BACKGROUND: Modern cognitive neuropsychological models of depression posit that negatively biased emotional ("hot") processing confers risk for depression, while preserved executive function ("cold") cognition promotes...
Viral Metagenomic Analysis of Cerebrospinal Fluid from Patients with Acute Central Nervous System Infections of Unknown Origin, Vietnam.
Nguyen To Anh, Le Nguyen Truc Nhu, Nguyen Thi Thu Hong, Tran My Phuc, Pham Thi Thanh Tam, Dang Thao Huong, Tran Tuan Anh, Xutao Deng, Ho Dang Trung Nghia, Tran Thua Nguyen, Nguyen Van Hung, Nguyen Dac Thuan, Pham Thi Hong Phuong, Nguyen Van Vinh Chau, Stephen Baker, Eric Delwart, Guy Thwaites, Le Van Tan, VIZIONS Consortium1
May 17, 2021
Central nervous system (CNS) infection is a serious neurologic condition, although the etiology remains unknown in >50% of patients. We used metagenomic next-generation sequencing to detect viruses in 204 cerebrospinal fluid...
Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions.
Luis V Nobre, Katie Nightingale, Benjamin J Ravenhill, Robin Antrobus, Lior Soday, Jenna Nichols, James A Davies, Sepehr Seirafian, Eddie CY Wang, Andrew J Davison, Gavin WG Wilkinson, Richard J Stanton, Edward L Huttlin, Michael P Weekes
Jan 29, 2020
Human cytomegalovirus (HCMV) extensively modulates host cells, downregulating >900 human proteins during viral replication and degrading ≥133 proteins shortly after infection. The mechanism of degradation of most host proteins...
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