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Probing the Solution Structure of IκB Kinase (IKK) Subunit γ and Its Interaction with Kaposi Sarcoma-associated Herpes Virus Flice-interacting Protein and IKK Subunit β by EPR Spectroscopy.
Claire Bagnéris, Kacper B Rogala, Mehdi Baratchian, Vlad Zamfir, Micha BA Kunze, Selina Dagless, Katharina F Pirker, Mary K Collins, Benjamin A Hall, Tracey E Barrett, Christopher WM Kay
Sep 05, 2018
Viral flice-interacting protein (vFLIP), encoded by the oncogenic Kaposi sarcoma-associated herpes virus (KSHV), constitutively activates the canonical nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) pathway....
IKKγ NEMO NF-kappa B (NF-κB) electron paramagnetic resonance (EPR) Molecular dynamics molecular modeling Protein Structure signalosome vFLIP Virology Amino Acid Motifs Binding Sites Electron Spin Resonance Spectroscopy Herpesvirus 8 Human Humans I-kappa B Kinase Protein Binding Sarcoma Kaposi Viral Proteins
An Asymptotic Radius of Convergence for the Loewner Equation and Simulation of SLE <sub>κ</sub> Traces via Splitting
In this paper, we study the convergence of Taylor approximations for the backward SLE maps near the origin. In addition, this result highlights the limitations of using stochastic Taylor methods for approximating SLE...
MRI of Bladder Cancer
Iztok Caglic, Valeria Panebianco, Hebert A Vargas, Vlad Bura, Sungmin Woo, Martina Pecoraro, Stefano Cipollari, Evis Sala, Tristan Barrett
Jan 27, 2020
Accurate staging of bladder cancer (BC) is critical, with local tumor staging directly influencing management decisions and affecting prognosis. However, clinical staging based on clinical examination, including cystoscopy and...
An Asymptotic Radius of Convergence for the Loewner Equation and Simulation of SLE <sub>κ</sub> Traces via Splitting
In this paper, we study the convergence of Taylor approximations for the backward SLE maps near the origin. In addition, this result highlights the limitations of using stochastic Taylor methods for approximating SLE...
CT/MRI LI-RADS v2018 vs. CEUS LI-RADS v2017-Can Things Be Put Together?
Different LI-RADS core documents were released for CEUS and for CT/MRI. Both documents rely on major and ancillary diagnostic criteria. The present paper offers an exhaustive comparison of the two documents focusing on the...
Published by: Biology
CT/MRI LI-RADS v2018 vs. CEUS LI-RADS v2017—Can Things Be Put Together?
Different LI-RADS core documents were released for CEUS and for CT/MRI. Both documents rely on major and ancillary diagnostic criteria. The present paper offers an exhaustive comparison of the two documents focusing on the...
CT/MRI LI-RADS v2018 vs. CEUS LI-RADS v2017-Can Things Be Put Together?
Different LI-RADS core documents were released for CEUS and for CT/MRI. Both documents rely on major and ancillary diagnostic criteria. The present paper offers an exhaustive comparison of the two documents focusing on the...
MRI features of the normal prostatic peripheral zone
Vlad Bura, Iztok Caglic, Ziga Snoj, Nikita Sushentsev, Alexandra S Berghe, Andrew N Priest, Tristan Barrett
Nov 16, 2020
OBJECTIVES: To assess the multiparametric MRI (mpMRI) appearances of normal peripheral zone (PZ) across age groups in a biopsy-naïve population, where prostate cancer (PCa) was subsequently excluded, and propose a scoring system...
Oxidising and carburising catalyst conditioning for the controlled growth and transfer of large crystal monolayer hexagonal boron nitride
Vitaliy Babenko, Ye Fan, Vlad-Petru Veigang-Radulescu, Barry Brennan, Andrew J Pollard, Oliver Burton, Jack A Alexander-Webber, Robert S Weatherup, Barbara Canto, Martin Otto, Daniel Neumaier, Stephan Hofmann
Nov 16, 2020
Oxidising and carburising catalyst conditioning for the controlled growth and transfer of large crystal monolayer hexagonal boron nitride
Vitaliy Babenko, Ye Fan, Vlad-Petru Veigang-Radulescu, Barry Brennan, Andrew J Pollard, Oliver Burton, Jack A Alexander-Webber, Robert S Weatherup, Barbara Canto, Martin Otto, Daniel Neumaier, Stephan Hofmann
Nov 16, 2020
A highly stable, nanotube-enhanced, CMOS-MEMS thermal emitter for mid-IR gas sensing
Daniel Popa, Richard Hopper, Syed Zeeshan Ali, Matthew Cole, Ye Fan, Vlad-Petru Veigang-Radulescu, Rohit Chikkaraddy, Jayakrupakar Nallala, Yuxin Xing, Jack Allen Alexander-Webber, Stephan Hofmann, Andrea De Luca, Julian William Gardner, Florin Udrea
Dec 15, 2021
Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease.
Partho Sen, Olivier Govaere, Tim Sinioja, Aidan McGlinchey, Dawei Geng, Vlad Ratziu, Elisabetta Bugianesi, Jörn M Schattenberg, Antonio Vidal-Puig, Michael Allison, Simon Cockell, Ann K Daly, Tuulia Hyötyläinen, Quentin M Anstee, Matej Orešič
Oct 06, 2022
Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent disease that is associated with multiple metabolic disturbances, yet the metabolic pathways underlying its progression are poorly understood. Here, we studied...
Understanding metal organic chemical vapour deposition of monolayer WS2
Integrated Wafer Scale Growth of Single Crystal Metal Films and High Quality Graphene.
Oliver J Burton, Fabien C-P Massabuau, Vlad-Petru Veigang-Radulescu, Barry Brennan, Andrew J Pollard, Stephan Hofmann
Oct 07, 2020
We report on an approach to bring together single crystal metal catalyst preparation and graphene growth in a combined process flow using a standard cold-wall chemical vapor deposition (CVD) reactor. We employ a sandwich...
Low AC Loss Inkjet-Printed Multifilamentary YBCO Coated Conductors
SC Hopkins, TB Mitchell-Williams, DR Vanden Bussche, A Calleja, VR Vlad, M Vilardell, X Granados, T Puig, X Obradors, A Usoskin, M Soloviov, M Vojenciak, F Gomory, IV Driessche, M Backer, BA Glowacki
Mar 18, 2016
A single promoter-TALE system for tissue-specific and tuneable expression of multiple genes in rice.
Florence Danila, Tom Schreiber, Maria Ermakova, Lei Hua, Daniela Vlad, Shuen-Fang Lo, Yi-Shih Chen, Julia Lambret-Frotte, Anna S Hermanns, Benedikt Athmer, Susanne Von Caemmerer, Su-May Yu, Julian M Hibberd, Alain Tissier, Robert T Furbank, Steven Kelly, Jane A Langdale
Jun 29, 2022
Lesion-specific 3D-printed moulds for image-guided tissue multi-sampling of ovarian tumours
Maria Delgado-Ortet, Marika Av Reinius, Cathal McCague, Vlad Bura, Ramona Woitek, Leonardo Rundo, Andrew B Gill, Marcel Gehrung, Stephan Ursprung, Helen Bolton, Krishnayan Haldar, Pubudu Pathiraja, James D Brenton, Mireia Crispin-Ortuzar, Mercedes Jimenez-Linan, Lorena Escudero Sanchez, Evis Sala
Feb 27, 2023
Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.
Aidan J McGlinchey, Olivier Govaere, Dawei Geng, Vlad Ratziu, Michael Allison, Jerome Bousier, Salvatore Petta, Claudia de Oliviera, Elisabetta Bugianesi, Jörn M Schattenberg, Ann K Daly, Tuulia Hyötyläinen, Quentin M Anstee, Matej Orešič
May 18, 2022
2-HB 2-hydroxybutanoic acid 3-HB 3-hydroxybutanoic acid ALT alanine aminotransferase AST aspartate aminotransferase Ce cholesterol ester Cer ceramide FFA free fatty acid FLIP Fatty Liver Inhibition of Progression Fibrosis GC gas chromatography HCC hepatocellular carcinoma HSD honest significant difference LC lipid cluster LDL low-density lipoprotein LM lipid and metabolite LMC lipid metabolite and clinical variable LPC lysophosphatidylcholine lipidomics Mass Spectrometry Metabolomics NAFL non-alcoholic fatty liver NAFLD non-alcoholic fatty liver disease NAS NASH activity score NASH non-alcoholic steatohepatitis NIDDK NASH-CRN National Institute of Digestive Diseases and Kidney NASH Clinical Research Network NRR non-rejection rate Non-alcoholic steatohepatitis PC(O) ether PC PC phosphatidylcholine PCA principal component analysis PE phosphatidylethanolamine QTOFMS quadrupole-time-of-flight mass spectrometry ROC receiving operator characteristic SAF steatosis activity and fibrosis SM sphingomyelin T2DM type 2 diabetes mellitus TG triacylglycerol UHPLC ultrahigh-performance liquid chromatography
Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.
Michele Vacca, Jack Leslie, Samuel Virtue, Brian YH Lam, Olivier Govaere, Dina Tiniakos, Sophie Snow, Susan Davies, Kasparas Petkevicius, Zhen Tong, Vivian Peirce, Mette Juul Nielsen, Zsuzsanna Ament, Wei Li, Tomasz Kostrzewski, Diana Julie Leeming, Vlad Ratziu, Michael ED Allison, Quentin M Anstee, Julian L Griffin, Fiona Oakley, Antonio Vidal-Puig
May 04, 2020
Clinically Interpretable Radiomics-Based Prediction of Histopathologic Response to Neoadjuvant Chemotherapy in High-Grade Serous Ovarian Carcinoma.
Leonardo Rundo, Lucian Beer, Lorena Escudero Sanchez, Mireia Crispin-Ortuzar, Marika Reinius, Cathal McCague, Hilal Sahin, Vlad Bura, Roxana Pintican, Marta Zerunian, Stephan Ursprung, Iris Allajbeu, Helen Addley, Paula Martin-Gonzalez, Thomas Buddenkotte, Naveena Singh, Anju Sahdev, Ionut-Gabriel Funingana, Mercedes Jimenez-Linan, Florian Markowetz, James D Brenton, Evis Sala, Ramona Woitek
Jun 30, 2022
BACKGROUND: Pathological response to neoadjuvant treatment for patients with high-grade serous ovarian carcinoma (HGSOC) is assessed using the chemotherapy response score (CRS) for omental tumor deposits. The main limitation of...
The European NAFLD Registry
Timothy Hardy, Kristy Wonders, Ramy Younes, Guruprasad P Aithal, Rocio Aller, Michael Allison, Pierre Bedossa, Fay Betsou, Jerome Boursier, M Julia Brosnan, Alastair Burt, Jeremy Cobbold, Helena Cortez-Pinto, Chris P Day, Jean-Francois Dufour, Mattias Ekstedt, Sven Francque, Stephen Harrison, Luca Miele, Patrik Nasr, George Papatheodoridis, Salvatore Petta, Dina Tiniakos, Richard Torstenson, Luca Valenti, Adriaan G Holleboom, Hannele Yki-Jarvinen, Andreas Geier, Manuel Romero-Gomez, Vlad Ratziu, Elisabetta Bugianesi, Jörn M Schattenberg, Quentin M Anstee, LITMUS Consortium
Dec 16, 2020
Non-Alcoholic Fatty Liver Disease (NAFLD), a progressive liver disease that is closely associated with obesity, type 2 diabetes, hypertension and dyslipidaemia, represents an increasing global public health challenge. There is...
NASH limits anti-tumour surveillance in immunotherapy-treated HCC.
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D'Alessio, Nicola Personeni, Lorenza Rimassa, Ann K Daly, Bernhard Scheiner, Katharina Pomej, Martha M Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N Marche, Thomas Decaens, David J Pinato, Roland Rad, Joachim C Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M Llovet, Mathias Heikenwalder
May 05, 2021
Hepatocellular carcinoma (HCC) can have viral or non-viral causes1-5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of...
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Dominik Pfister, Nicolás Gonzalo Núñez, Roser Pinyol, Olivier Govaere, Matthias Pinter, Marta Szydlowska, Revant Gupta, Mengjie Qiu, Aleksandra Deczkowska, Assaf Weiner, Florian Müller, Ankit Sinha, Ekaterina Friebel, Thomas Engleitner, Daniela Lenggenhager, Anja Moncsek, Danijela Heide, Kristin Stirm, Jan Kosla, Eleni Kotsiliti, Valentina Leone, Michael Dudek, Suhail Yousuf, Donato Inverso, Indrabahadur Singh, Ana Teijeiro, Florian Castet, Carla Montironi, Philipp K. Haber, Dina Tiniakos, Pierre Bedossa, Simon Cockell, Ramy Younes, Michele Vacca, Fabio Marra, Jörn M. Schattenberg, Michael Allison, Elisabetta Bugianesi, Vlad Ratziu, Tiziana Pressiani, Antonio D’Alessio, Nicola Personeni, Lorenza Rimassa, Ann K. Daly, Bernhard Scheiner, Katharina Pomej, Martha M. Kirstein, Arndt Vogel, Markus Peck-Radosavljevic, Florian Hucke, Fabian Finkelmeier, Oliver Waidmann, Jörg Trojan, Kornelius Schulze, Henning Wege, Sandra Koch, Arndt Weinmann, Marco Bueter, Fabian Rössler, Alexander Siebenhüner, Sara De Dosso, Jan-Philipp Mallm, Viktor Umansky, Manfred Jugold, Tom Luedde, Andrea Schietinger, Peter Schirmacher, Brinda Emu, Hellmut G. Augustin, Adrian Billeter, Beat Müller-Stich, Hiroto Kikuchi, Dan G. Duda, Fabian Kütting, Dirk-Thomas Waldschmidt, Matthias Philip Ebert, Nuh Rahbari, Henrik E. Mei, Axel Ronald Schulz, Marc Ringelhan, Nisar Malek, Stephan Spahn, Michael Bitzer, Marina Ruiz de Galarreta, Amaia Lujambio, Jean-Francois Dufour, Thomas U. Marron, Ahmed Kaseb, Masatoshi Kudo, Yi-Hsiang Huang, Nabil Djouder, Katharina Wolter, Lars Zender, Parice N. Marche, Thomas Decaens, David J. Pinato, Roland Rad, Joachim C. Mertens, Achim Weber, Kristian Unger, Felix Meissner, Susanne Roth, Zuzana Macek Jilkova, Manfred Claassen, Quentin M. Anstee, Ido Amit, Percy Knolle, Burkhard Becher, Josep M. Llovet, Mathias Heikenwalder
Apr 14, 2021
Abstract: Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based...