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Results: 5
Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
Vojislav Jovanović, Nurhuda Abdul Aziz, Yan Ting Lim, Amanda Ng Ai Poh, Sherlynn Jin Hui Chan, Eliza Ho Xin Pei, Fei Chuin Lew, Guanghou Shui, Andrew M Jenner, Li Bowen, Eoin F McKinney, Paul A Lyons, Michael D Kemeny, Kenneth GC Smith, Markus R Wenk, Paul A Macary
Sep 20, 2018
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and...
A CD8+ T cell transcription signature predicts prognosis in autoimmune disease.
Eoin F McKinney, Paul A Lyons, Edward J Carr, Jane L Hollis, David RW Jayne, Lisa C Willcocks, Maria Koukoulaki, Alvis Brazma, Vojislav Jovanovic, D Michael Kemeny, Andrew J Pollard, Paul A Macary, Afzal N Chaudhry, Kenneth GC Smith
Nov 24, 2020
Autoimmune diseases are common and debilitating, but their severe manifestations could be reduced if biomarkers were available to allow individual tailoring of potentially toxic immunosuppressive therapy. Gene expression-based...
Antibodies Antineutrophil Cytoplasmic Autoimmune Diseases Autoimmunity CD8-Positive T-Lymphocytes Cohort Studies Dose-Response Relationship Drug Gene Expression Humans Immunosuppressive Agents Inflammation Interleukin-7 Lupus Erythematosus Systemic Prognosis Receptors Antigen T-Cell Signal Transduction T-Lymphocytes Vasculitis
EN1 Is a Transcriptional Dependency in Triple-Negative Breast Cancer Associated with Brain Metastasis.
Guillermo Peluffo, Ashim Subedee, Nicholas W Harper, Natalie Kingston, Bojana Jovanović, Felipe Flores, Laura E Stevens, Francisco Beca, Anne Trinh, Chandra Sekhar Reddy Chilamakuri, Evangelia K Papachristou, Katherine Murphy, Ying Su, Andriy Marusyk, Clive S D'Santos, Oscar M Rueda, Andrew H Beck, Carlos Caldas, Jason S Carroll, Kornelia Polyak
Jul 09, 2019
To define transcriptional dependencies of triple-negative breast cancer (TNBC), we identified transcription factors highly and specifically expressed in primary TNBCs and tested their requirement for cell growth in a panel of...
Phenotypic screening reveals TNFR2 as a promising target for cancer immunotherapy.
Geoffrey S Williams, Bina Mistry, Sandrine Guillard, Jane Coates Ulrichsen, Alan M Sandercock, Jun Wang, Andrea González-Muñoz, Julie Parmentier, Chelsea Black, Jo Soden, Jim Freeth, Jelena Jovanović, Rebecca Leyland, Rafia S Al-Lamki, Andrew J Leishman, Steven J Rust, Ross Stewart, Lutz Jermutus, John R Bradley, Vahe Bedian, Viia Valge-Archer, Ralph Minter, Robert W Wilkinson
Jul 20, 2018
TNFR2 cancer immunotherapy Drug Discovery phenotypic screening Regulatory T cell Animals Antineoplastic Agents Cell Line Tumor Drug Screening Assays Antitumor Female HEK293 Cells Humans Immunotherapy Jurkat Cells Mice Inbred BALB C NF-kappa B Neoplasms Neoplasms Experimental Phenotype Receptors Tumor Necrosis Factor Type II Signal Transduction T-Lymphocytes Regulatory
Leucocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases.