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Time course of functional changes in locomotor and sensory systems after spinal cord lesions in lamprey.
Changes in motor and sensory properties occur either side of spinal cord lesion sites from lower vertebrates to humans. We have previously examined these changes in the lamprey, a model system for studying recovery after spinal...
Noncanonical mitochondrial unfolded protein response impairs placental oxidative phosphorylation in early-onset preeclampsia.
Hong Wa Yung, Francesca Colleoni, Emilie Dommett, Tereza Cindrova-Davies, John Kingdom, Andrew J Murray, Graham J Burton
Jul 31, 2019
Preeclampsia (PE) is a dangerous complication of pregnancy, especially when it presents at <34 wk of gestation (PE < 34 wk). It is a major cause of maternal and fetal morbidity and mortality and also increases the risk of...
Mitochondria Preeclampsia Unfolded Protein Response Activating Transcription Factors Chaperonin 60 Eukaryotic Initiation Factor-2 Female HSP70 Heat-Shock Proteins Humans Mitochondria Mitochondrial Proteins Oxidative Phosphorylation pre-eclampsia Pregnancy Trophoblasts Unfolded Protein Response eIF-2 Kinase
Climate-Smart Cocoa in Ghana
Climate-smart agriculture (CSA) aims to transform and reorient farming systems to decrease greenhouse gas emissions, boost adaptive capacity, and improve productivity while supporting incomes and, ostensibly, food security. In...
Institutional complexity and paradox theory
Organizational success increasingly depends on leaders’ abilities to address competing demands simultaneously. Scholars have applied both institutional theory and paradox theory to better understand the nature and responses to...
A crosssectional analysis of Facebook comments to study public perception of a new diagnostic test called the Cytosponge.
Social media provides a useful platform for informal discussions about healthcare. Acceptability is key to the uptake of diagnostic devices and this can be difficult to gauge from questionnaires and qualitative studies. The aim...
A temperature-dependent multilayer model for direct current carrying HTS coated-conductors under perpendicular AC magnetic fields
Abstract
When a type II superconductor carrying a direct current is subjected to a perpendicular oscillating magnetic field, a direct current (DC) voltage will appear. This voltage...
Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice.
Kirsty Foote, Johannes Reinhold, Emma PK Yu, Nichola L Figg, Alison Finigan, Michael P Murphy, Martin R Bennett
Jun 28, 2018
Aging is the largest risk factor for cardiovascular disease, yet the molecular mechanisms underlying vascular aging remain unclear. Mitochondrial DNA (mtDNA) damage is linked to aging, but whether mtDNA damage or mitochondrial...
Impacts of changes in environmental exposures and health behaviours due to the COVID-19 pandemic on cardiovascular and mental health
Sarah Koch, Sasha Khomenko, Marta Cirach, Mònica Ubalde-Lopez, Sacha Baclet, Carolyn Daher, Laura Hidalgo, Mare Lõhmus, Debora Rizzuto, Romain Rumpler, Yusak Susilo, Siddharth Venkataraman, Sandra Wegener, Gregory A Wellenius, James Woodcock, Mark Nieuwenhuijsen
May 09, 2022
Responses to COVID-19 altered environmental exposures and health behaviours associated with non-communicable diseases. We aimed to (1) quantify changes in nitrogen dioxide (NO2), noise, physical activity, and greenspace visits...
Dendritic Cells Charged with Apoptotic Tumor Cells Induce Long-Lived Protective CD4+ and CD8+ T Cell Immunity against B16 Melanoma
Dendritic cells (DCs) are potent APCs and attractive vectors for cancer immunotherapy. Using the B16 melanoma, a poorly immunogenic experimental tumor that expresses low levels of MHC class I products, we investigated whether...
Apoptosis bone marrow cell antigen recognition cytokine release lymph node lymphatic drainage melanoma cell tumor immunity
Published by: Rockefeller University
Identification of proliferating dendritic cell precursors in mouse blood
While it has been known that dendritic cells arise from proliferating precursors in situ, it has been difficult to identify progenitors in culture. We find that aggregates of growing dendritic cells develop in cultures of mouse...
Autoradiography blood culture Cell Aggregation dendritic cell immunoperoxidase staining mixed lymphocyte reaction t lymphocyte activation stem cell
Published by: Rockefeller University
Hyperventilation Syndrome
Christopher YK Williams, Robert WK Williams, Richard Knight, Syed Hashmi, Neil Donnelly, Manohar Bance
Apr 17, 2020
OBJECTIVE: To explore the Nijmegen Questionnaire (NQ) and its relationship to vestibular function tests and symptoms in patients with dizziness; to compare patient characteristics between those with a positive Nijmegen score and...
CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
In the nonobese diabetic (NOD) mouse model of type 1 diabetes, the immune system recognizes many autoantigens expressed in pancreatic islet ? cells. To silence autoimmunity, we used dendritic cells (DCs) from NOD mice to expand...
Autoimmunity BDC2.5 CD25+ CD4+ regulatory T cells dendritic cell insulin-dependent diabetes mellitus
Published by: Rockefeller University
Etiologic Classification Criteria of ARCO on Femoral Head Osteonecrosis Part 2
Byung-Ho Yoon, Lynne C Jones, Chung-Hwan Chen, Edward Y Cheng, Quanjun Cui, Wolf Drescher, Wakaba Fukushima, Valerie Gangji, Stuart B Goodman, Yong-Chan Ha, Philippe Hernigou, Marc Hungerford, Richard Iorio, Woo-Lam Jo, Vikas Khanduja, Harry Kim, Shin-Yoon Kim, Tae-Young Kim, Hee Young Lee, Mel S Lee, Young-Kyun Lee, Yun Jong Lee, Michael A Mont, Takashi Sakai, Nobuhiko Sugano, Masaki Takao, Takuaki Yamamoto, Kyung-Hoi Koo
Apr 04, 2019
BACKGROUND: Although alcohol is a leading risk factor for osteonecrosis of the femoral head (ONFH) and its prevalence reportedly ranges from 20% to 45%, there are no unified classification criteria for this subpopulation. In...
Salivary Immunoendocrine and Self-Report Monitoring Profiles Across an Elite-Level Professional Football Season
Matthew Springham, Sean Williams, Mark Waldron, Anthony J Strudwick, Chris Mclellan, Robert Newton
May 31, 2021
PURPOSE: This investigation examined the longitudinal changes and interrelationships of salivary and self-report monitoring measures across a professional football season. METHODS: Measures were collected biweekly from 18...
Geminate and Nongeminate Pathways for Triplet Exciton Formation in Organic Solar Cells
A Privitera, J Grüne, A Karki, WK Myers, V Dyakonov, TQ Nguyen, MK Riede, RH Friend, A Sperlich, AJ Gillett
Mar 17, 2022
Abstract: Organic solar cells (OSCs) have recently shown a rapid improvement in their performance, bringing power conversion efficiencies to above 18%. However, the open‐circuit voltage of OSCs remains low relative to their...
Low-dose thiamine supplementation of lactating Cambodian mothers improves human milk thiamine concentrations
Jelisa Gallant, Kathleen Chan, Tim J Green, Frank T Wieringa, Shalem Leemaqz, Rem Ngik, Jeffrey R Measelle, Dare A Baldwin, Mam Borath, Prak Sophonneary, Lisa N Yelland, Daniela Hampel, Setareh Shahab-Ferdows, Lindsay H Allen, Kerry S Jones, Albert Koulman, Damon A Parkington, Sarah R Meadows, Hou Kroeun, Kyly C Whitfield
Apr 19, 2021
BACKGROUND: Infantile beriberi-related mortality is still common in South and Southeast Asia. Interventions to increase maternal thiamine intakes, and thus human milk thiamine, are warranted; however, the required dose remains...
Salivary Immunoendocrine and Self-Report Monitoring Profiles Across an Elite-Level Professional Football Season
Matthew Springham, Sean Williams, Mark Waldron, Anthony J Strudwick, Chris Mclellan, Robert Newton
May 31, 2021
PURPOSE: This investigation examined the longitudinal changes and interrelationships of salivary and self-report monitoring measures across a professional football season. METHODS: Measures were collected biweekly from 18...
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