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Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer.
Nicolas J Walker, Mamunur Rashid, Shirong Yu, Helen Bignell, Casper K Lumby, Carmen M Livi, Kate Howell, David J Morley, Sandro Morganella, Daniel Barrell, Shabhonam Caim, Walraj Gosal, Jens Füllgrabe, Thomas J Charlesworth, Louella Vasquez, Miika Ahdesmäki, Jordan Eizenga, Parul Prabhat, Vitali Proutski, Marie Laurie Murat-Onana, Catherine J Greenwood, Lisa Kirkwood, Meeta Maisuria-Armer, Mengjie Li, Emma Coats, Victoria Winfield, Lachlan MacBean, Toby Stock, Alice Tomé-Fernandez, Yat Chan, Nasir Sheikh, Paula Golder, Michael Steward, Tobias WB Ost, Douglas Stewart, Albert Vilella, Mojtaba Noursalehi, Benedict Paten, Debora Lucarelli, Joanne Mason, Gareth Ridge, Jason Mellad, Suman Shirodkar, Shankar Balasubaramanian, Joanna D Holbrook
Oct 04, 2022
Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we...
Investigating genotype-phenotype relationship of extreme neuropathic pain disorders in a UK national cohort.
Andreas C Themistocleous, Georgios Baskozos, Iulia Blesneac, Maddalena Comini, Karyn Megy, Sam Chong, Sri VV Deevi, Lionel Ginsberg, David Gosal, Robert DM Hadden, Rita Horvath, Mohamed Mahdi-Rogers, Adnan Manzur, Rutendo Mapeta, Andrew Marshall, Emma Matthews, Mark I McCarthy, Mary M Reilly, Tara Renton, Andrew SC Rice, Tom A Vale, Natalie van Zuydam, Suellen M Walker, Christopher Geoffrey Woods, David LH Bennett
Apr 09, 2023
The aims of our study were to use whole genome sequencing in a cross-sectional cohort of patients to identify new variants in genes implicated in neuropathic pain, to determine the prevalence of known pathogenic variants and to...