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Molecular Mechanism of Z α1-Antitrypsin Deficiency.
Xin Huang, Ying Zheng, Fei Zhang, Zhenquan Wei, Yugang Wang, Robin W Carrell, Randy J Read, Guo-Qiang Chen, Aiwu Zhou
Feb 12, 2020
The Z mutation (E342K) of α1-antitrypsin (α1-AT), carried by 4% of Northern Europeans, predisposes to early onset of emphysema due to decreased functional α1-AT in the lung and to liver cirrhosis due to accumulation of polymers...
Application of English Multi-Modal Reading Teaching Mode in the Context of “Internet Plus”
Wei Guo
Jan 01, 2024
Under the background of “Internet plus”, the application of English multi-modal reading teaching mode is of great significance. With the continuous development of Internet technology, the field of education has also been deeply...
Published by: IGI Global Scientific Publishing
Cracking the enigma of mitochondrial-DNA variants and cancer.
A recent study by Yuan et al., [Ref. 11] published in Nature Genetics, demonstrated multidimensional molecular alterations of mitochondrial DNA in human cancers and provide an on-line catalogue of mitochondrial genomes in many...
Optimisation for interconnected energy hub system with combined ground source heat pump and borehole thermal storage
Ground source heat pumps (GSHP) give zero-carbon emission heating at a residential level. However, as the heat is discharged, the temperature of the ground drops, leading to a poorer efficiency. Borehole inter-seasonal thermal...
Cell reprogramming shapes the mitochondrial DNA landscape
Abstract: Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC...
Biparental inheritance of mitochondrial DNA revisited.
Evidence for a biparental mode of mitochondrial DNA (mtDNA) inheritance has been sparse and remains controversial. Recent studies using a range of complementary techniques do not support paternal transmission of mtDNA, and...
Cell reprogramming shapes the mitochondrial DNA landscape.
Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC and...
Water Resources Assessment and Management for Nuclear Power Plants in China
To deal with global warming and energy shortage, nuclear power plants are constructed or planning to be constructed in China presently. The operation of a nuclear power plant consumes a great amount of water and discharges a lot...
Cell reprogramming shapes the mitochondrial DNA landscape.
Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC and...
FIBROBLASTS Humans DNA Mitochondrial Gene Expression Mutation Adult Aged Middle Aged Female Male Genome Mitochondrial Young Adult Induced Pluripotent Stem Cells Cellular Reprogramming Cellular Senescence heteroplasmy
Published by: Nature Communications
Optimisation for interconnected energy hub system with combined ground source heat pump and borehole thermal storage
Ground source heat pumps (GSHP) give zero-carbon emission heating at a residential level. However, as the heat is discharged, the temperature of the ground drops, leading to a poorer efficiency. Borehole inter-seasonal thermal...
Optimal Borehole Energy Storage Charging Strategy in a Low Carbon Space Heat System
Domestic heating is the major demand of energy systems, which can bring significant uncertainties to system operation and shrink the security margin. From this aspect, the borehole system, as an interseasonal heating storage...
air source heat pump (ASHP) ground source heat pump (GSHP) Inter-seasonal borehole thermal energy storage (BTES) optimal charging strategy photovoltaic (PV) /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Energy Harvesting from Ultra-low-Frequency Vibrations Through a Quasi-zero Stiffness Electromagnetic Energy Harvester
Purpose: To scavenge vibrational energy from ultra-low frequency vibrations with low excitation levels, this paper presents a novel quasi-zero stiffness electromagnetic energy harvester (QZS-EMEH) by exploiting a rolling...
Energy Harvesting from Ultra-low-Frequency Vibrations Through a Quasi-zero Stiffness Electromagnetic Energy Harvester
Purpose: To scavenge vibrational energy from ultra-low frequency vibrations with low excitation levels, this paper presents a novel quasi-zero stiffness electromagnetic energy harvester (QZS-EMEH) by exploiting a rolling...
3, 4-dihydroxyl-phenyl lactic acid restores NADH dehydrogenase 1 α subunit 10 to ameliorate cardiac reperfusion injury.
Xiao-Yuan Yang, Ke He, Chun-Shui Pan, Quan Li, Yu-Ying Liu, Li Yan, Xiao-Hong Wei, Bai-He Hu, Xin Chang, Xiao-Wei Mao, Dan-Dan Huang, Li-Jun Wang, Shui-Wang Hu, Yong Jiang, Guo-Cheng Wang, Jing-Yu Fan, Tai-Ping Fan, Jing-Yan Han
Jan 10, 2018
The present study aimed to detect the role of 3, 4-dihydroxyl-phenyl lactic acid (DLA) during ischemia/reperfusion (I/R) induced myocardial injury with emphasis on the underlying mechanism of DLA antioxidant. Male Spragu-Dawley...
Animals Apoptosis Cardiotonic Agents Cell Line Disease Models Animal Electron Transport Complex I Gene Expression Lactic Acid Leukocytes Male Mitochondria Myocardial Infarction Myocardial Reperfusion Injury NADH Dehydrogenase Protein Binding Protein Subunits Rats Reactive Oxygen Species Sirtuin 1 Ventricular Function Left
Water Resources Assessment and Management for Nuclear Power Plants in China
To deal with global warming and energy shortage, nuclear power plants are constructed or planning to be constructed in China presently. The operation of a nuclear power plant consumes a great amount of water and discharges a lot...
Optimal operation of interconnected energy hubs by using decomposed hybrid particle swarm and interior-point approach
The Energy Hub has become an important concept for formally optimizing multi-carrier energy infrastructure to increase system flexibility and efficiency. The existence of energy storage within energy hubs enables the dynamic...
energy hub Energy sharing Energy storage Multi-period optimization Particle swarm optimization /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations.
Inherited mitochondrial DNA (mtDNA) mutations have emerged as a common cause of human disease, with mutations occurring multiple times in the world population. The clinical presentation of three pathogenic mtDNA mutations is...
Chance-Constrained Optimization for MultiEnergy Hub Systems in a Smart City
The energy hub is a powerful conceptualization of how to acquire, convert, and distribute energy resources in the smart city. However, uncertainties such as intermittent renewable energy injection present challenges to energy...
Chance-constrained programming (CCP) Cornish-Fisher expansion energy hub optimal flow /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
Chance-Constrained Optimization for MultiEnergy Hub Systems in a Smart City
The energy hub is a powerful conceptualization of how to acquire, convert, and distribute energy resources in the smart city. However, uncertainties such as intermittent renewable energy injection present challenges to energy...
Chance-constrained programming (CCP) Cornish-Fisher expansion energy hub optimal flow /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
Optimal operation of interconnected energy hubs by using decomposed hybrid particle swarm and interior-point approach
The Energy Hub has become an important concept for formally optimizing multi-carrier energy infrastructure to increase system flexibility and efficiency. The existence of energy storage within energy hubs enables the dynamic...
energy hub Energy sharing Energy storage Multi-period optimization Particle swarm optimization /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis.
Bone Morphogenetic Protein (BMP) Cell Signaling Crystal structure Disulfide Endothelial Cell Redox Regulation Animals Cell Line Crystallization Crystallography X-Ray DNA Complementary Dimerization Disulfides Endothelial Cells Gene Expression Regulation Growth Differentiation Factor 2 Growth Differentiation Factors Humans Ligands Mice Oxidation-Reduction Phenotype Proteolysis Recombinant Proteins Signal Transduction
A Bone Morphogenetic Protein (BMP)-derived Peptide Based on the Type I Receptor-binding Site Modifies Cell-type Dependent BMP Signalling.
Cross-Module Enoylreduction in the Azalomycin F Polyketide Synthase.
Guifa Zhai, Wenyan Wang, Wei Xu, Guo Sun, Chaoqun Hu, Xiangming Wu, Zisong Cong, Liang Deng, Yanrong Shi, Peter F Leadlay, Heng Song, Kui Hong, Zixin Deng, Yuhui Sun
Oct 19, 2020
The colinearity of canonical modular polyketide synthases, which creates a direct link between multienzyme structure and the chemical structure of the biosynthetic end-product, has become a cornerstone of knowledge-based genome...
Formulation of Locational Marginal Electricity-Carbon Price in Power Systems
Decarbonisation of power systems is essential for realising carbon neutrality, in which the economic cost caused by carbon is needed to be qualified. Based on the formulation of locational marginal price (LMP), this paper...
Formulation of Locational Marginal Electricity-Carbon Price in Power Systems
Decarbonisation of power systems is essential for realising carbon neutrality, in which the economic cost caused by carbon is needed to be qualified. Based on the formulation of locational marginal price (LMP), this paper...
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