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Results: 1294
IL-21 promotes myocardial ischaemia/reperfusion injury through the modulation of neutrophil infiltration.
Kejing Wang, Shuang Wen, Jiao Jiao, Tingting Tang, Xin ZHAO, Min Zhang, Bingjie Lv, Yuzhi Lu, Xingdi Zhou, Jingyong Li, Shaofang Nie, Yuhua Liao, Qing Wang, Xin Tu, Ziad Mallat, Ni Xia, Xiang Cheng
Mar 25, 2019
BACKGROUND AND PURPOSE: The immune system plays an important role in driving the acute inflammatory response following myocardial ischaemia/reperfusion injury (MIRI). IL-21 is a pleiotropic cytokine with multiple...
Cracking the enigma of mitochondrial-DNA variants and cancer.
A recent study by Yuan et al., [Ref. 11] published in Nature Genetics, demonstrated multidimensional molecular alterations of mitochondrial DNA in human cancers and provide an on-line catalogue of mitochondrial genomes in many...
Optimisation for interconnected energy hub system with combined ground source heat pump and borehole thermal storage
Ground source heat pumps (GSHP) give zero-carbon emission heating at a residential level. However, as the heat is discharged, the temperature of the ground drops, leading to a poorer efficiency. Borehole inter-seasonal thermal...
Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures.
Jiao Li, Jakob Seidlitz, John Suckling, Feiyang Fan, Gong-Jun Ji, Yao Meng, Siqi Yang, Kai Wang, Jiang Qiu, Huafu Chen, Wei Liao
Mar 18, 2021
Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between brain structural changes in MDD and gene expression...
Cell reprogramming shapes the mitochondrial DNA landscape.
Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC and...
Water Resources Assessment and Management for Nuclear Power Plants in China
To deal with global warming and energy shortage, nuclear power plants are constructed or planning to be constructed in China presently. The operation of a nuclear power plant consumes a great amount of water and discharges a lot...
Cell reprogramming shapes the mitochondrial DNA landscape
Abstract: Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC...
Biparental inheritance of mitochondrial DNA revisited.
Evidence for a biparental mode of mitochondrial DNA (mtDNA) inheritance has been sparse and remains controversial. Recent studies using a range of complementary techniques do not support paternal transmission of mtDNA, and...
Optimisation for interconnected energy hub system with combined ground source heat pump and borehole thermal storage
Ground source heat pumps (GSHP) give zero-carbon emission heating at a residential level. However, as the heat is discharged, the temperature of the ground drops, leading to a poorer efficiency. Borehole inter-seasonal thermal...
Cell reprogramming shapes the mitochondrial DNA landscape.
Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC and...
FIBROBLASTS Humans DNA Mitochondrial Gene Expression Mutation Adult Aged Middle Aged Female Male Genome Mitochondrial Young Adult Induced Pluripotent Stem Cells Cellular Reprogramming Cellular Senescence heteroplasmy
Published by: Nature Communications
Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase.
Yaoyao Shen, Fan Sun, Liu Zhang, Yijia Cheng, Hongrui Zhu, Shu-Ping Wang, Wei-Hua Jiao, Peter F Leadlay, Yongjun Zhou, Hou-Wen Lin
Sep 11, 2020
Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS)...
Antibiotics anticancer drug chorismatase enzyme catalysis natural product biosynthesis non-ribosomal peptide synthetase (NRPS) polyketide synthase (PKS) Secondary Metabolism unantimycins Antibiotics Antineoplastic Bacterial Proteins Cell Line Tumor Cell Survival Depsipeptides Humans Hydroxybenzoates Organic Chemicals Polyketide Synthases Streptomyces
Optimal Borehole Energy Storage Charging Strategy in a Low Carbon Space Heat System
Domestic heating is the major demand of energy systems, which can bring significant uncertainties to system operation and shrink the security margin. From this aspect, the borehole system, as an interseasonal heating storage...
air source heat pump (ASHP) ground source heat pump (GSHP) Inter-seasonal borehole thermal energy storage (BTES) optimal charging strategy photovoltaic (PV) /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Energy Harvesting from Ultra-low-Frequency Vibrations Through a Quasi-zero Stiffness Electromagnetic Energy Harvester
Purpose: To scavenge vibrational energy from ultra-low frequency vibrations with low excitation levels, this paper presents a novel quasi-zero stiffness electromagnetic energy harvester (QZS-EMEH) by exploiting a rolling...
Energy Harvesting from Ultra-low-Frequency Vibrations Through a Quasi-zero Stiffness Electromagnetic Energy Harvester
Purpose: To scavenge vibrational energy from ultra-low frequency vibrations with low excitation levels, this paper presents a novel quasi-zero stiffness electromagnetic energy harvester (QZS-EMEH) by exploiting a rolling...
Water Resources Assessment and Management for Nuclear Power Plants in China
To deal with global warming and energy shortage, nuclear power plants are constructed or planning to be constructed in China presently. The operation of a nuclear power plant consumes a great amount of water and discharges a lot...
Optimal operation of interconnected energy hubs by using decomposed hybrid particle swarm and interior-point approach
The Energy Hub has become an important concept for formally optimizing multi-carrier energy infrastructure to increase system flexibility and efficiency. The existence of energy storage within energy hubs enables the dynamic...
energy hub Energy sharing Energy storage Multi-period optimization Particle swarm optimization /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Background sequence characteristics influence the occurrence and severity of disease-causing mtDNA mutations.
Inherited mitochondrial DNA (mtDNA) mutations have emerged as a common cause of human disease, with mutations occurring multiple times in the world population. The clinical presentation of three pathogenic mtDNA mutations is...
Chance-Constrained Optimization for MultiEnergy Hub Systems in a Smart City
The energy hub is a powerful conceptualization of how to acquire, convert, and distribute energy resources in the smart city. However, uncertainties such as intermittent renewable energy injection present challenges to energy...
Chance-constrained programming (CCP) Cornish-Fisher expansion energy hub optimal flow /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
Chance-Constrained Optimization for MultiEnergy Hub Systems in a Smart City
The energy hub is a powerful conceptualization of how to acquire, convert, and distribute energy resources in the smart city. However, uncertainties such as intermittent renewable energy injection present challenges to energy...
Chance-constrained programming (CCP) Cornish-Fisher expansion energy hub optimal flow /dk/atira/pure/subjectarea/asjc/2200/2207 name=Control and Systems Engineering /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
Optimal operation of interconnected energy hubs by using decomposed hybrid particle swarm and interior-point approach
The Energy Hub has become an important concept for formally optimizing multi-carrier energy infrastructure to increase system flexibility and efficiency. The existence of energy storage within energy hubs enables the dynamic...
energy hub Energy sharing Energy storage Multi-period optimization Particle swarm optimization /dk/atira/pure/subjectarea/asjc/2100/2102 name=Energy Engineering and Power Technology /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Regulation of bone morphogenetic protein 9 (BMP9) by redox-dependent proteolysis.
Bone Morphogenetic Protein (BMP) Cell Signaling Crystal structure Disulfide Endothelial Cell Redox Regulation Animals Cell Line Crystallization Crystallography X-Ray DNA Complementary Dimerization Disulfides Endothelial Cells Gene Expression Regulation Growth Differentiation Factor 2 Growth Differentiation Factors Humans Ligands Mice Oxidation-Reduction Phenotype Proteolysis Recombinant Proteins Signal Transduction
Cortical structural differences in major depressive disorder correlate with cell type-specific transcriptional signatures
Jiao Li, Jakob Seidlitz, John Suckling, Feiyang Fan, Gong-Jun Ji, Yao Meng, Siqi Yang, Kai Wang, Jiang Qiu, Huafu Chen, Wei Liao
Mar 12, 2021
Abstract: Major depressive disorder (MDD) has been shown to be associated with structural abnormalities in a variety of spatially diverse brain regions. However, the correlation between brain structural changes in MDD and gene...
Optimal Borehole Energy Storage Charging Strategy in a Low Carbon Space Heat System
Domestic heating is the major demand of energy systems, which can bring significant uncertainties to system operation and shrink the security margin. From this aspect, the borehole system, as an interseasonal heating storage...
air source heat pump (ASHP) ground source heat pump (GSHP) Inter-seasonal borehole thermal energy storage (BTES) optimal charging strategy photovoltaic (PV) /dk/atira/pure/subjectarea/asjc/1700/1700 name=General Computer Science /dk/atira/pure/subjectarea/asjc/2500/2500 name=General Materials Science /dk/atira/pure/subjectarea/asjc/2200/2200 name=General Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Towards a well-functioning stock market in context
The purpose of this paper is to summarise and reflect upon key issues at the interface of prices, information and regulation with a focus upon the stock market in context. Reflecting upon academic research in the area of...
Formulation of Locational Marginal Electricity-Carbon Price in Power Systems
Decarbonisation of power systems is essential for realising carbon neutrality, in which the economic cost caused by carbon is needed to be qualified. Based on the formulation of locational marginal price (LMP), this paper...
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