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The human DNA damage response (DDR) triggers profound changes in gene expression, whose nature and regulation remain uncertain. Although certain micro-(mi)RNA species including miR34, miR-18, miR-16 and miR-143 have been...

AP-1 activator protein-1 DDR DNA damage response DNA damage response E2F1 transcription factor E2F1 FOXM1 forkhead box protein M1 NF-k B nuclear factor-k B NGS next-generation sequencing TF transcription factor TP53 tumour protein p53 clinical outcome computational analysis double stranded DNA breaks DSBs ionizing radiation IR miRNA micro-RNA micro-RNA misc RNA miscellaneous RNA next-generation sequencing p53 scRNA small cytoplasmic RNA snRNA small nuclear RNA snoRNA small nucleolar RNA tRNA transfer RNA Cell Line DNA Damage DNA Repair Gene Expression Regulation Gene Expression Regulation Neoplastic Genome Genome Human Humans MicroRNAs Neoplasms Organ Specificity Tumor Suppressor Protein p53

Utility is the fundamental variable thought to underlie economic choices. In particular, utility functions are believed to reflect preferences toward risk, a key decision variable in many real-life situations. To assess the...

choice Decision Making experimental economics neuroeconomics stochastic dominance Animals Choice Behavior Decision Making Logistic Models Macaca mulatta Male Models Statistical Photic Stimulation Reward Risk-Taking

By observing their social partners, primates learn about reward values of objects. Here, we show that monkeys' amygdala neurons derive object values from observation and use these values to simulate a partner monkey's decision...

attractor network autism decision-making mirror neuron observational learning Reward Social cognition Theory of mind Amygdala Animals Behavior Animal Choice Behavior Decision Making Interpersonal Relations learning Macaca mulatta Male Neurons Reward

Bacterial Proteins Base Sequence Cloning Molecular Gene Transfer Horizontal Models Genetic Molecular Sequence Data Multigene Family Phylogeny Plasmids Rahnella Sequence Alignment Vegetables

An increasing observation is that some patients with COVID-19 have normal lung compliance but significant hypoxaemia different from typical acute respiratory distress syndrome (ARDS). We hypothesised that changes in pulmonary...

ARDS MRI Critical Care imaging/CT covid-19 Humans Lung Lung Compliance Pandemics Pulmonary Circulation Respiratory Function Tests Respiratory Mechanics Retrospective Studies SARS-CoV-2 Tomography X-Ray Computed

BACKGROUND AND PURPOSE: Autonomic nervous system (ANS) seems to play an important role in the post-stroke immunosuppression syndrome with increased susceptibility to infections. The aim of this study was to investigate if ANS...

autonomic baroreflex Infection Pneumonia stroke Adolescent Adult Aged Aged 80 and over baroreflex Brain Ischemia Cross Infection Female Humans Male Middle Aged Prospective Studies stroke Young Adult

BACKGROUND: Functional characterisation of the compact genome of the model organism Caenorhabditis elegans remains incomplete despite its sequencing 20 years ago. The last decade of research has seen a tremendous increase in the...

C. elegans CRISPR long non-coding RNA Non-coding LincRNA lncRNA Animals Caenorhabditis elegans Gene Expression Profiling Genome RNA Long Noncoding Transcriptome

We investigate the relationship between maternal cardiovascular (CV) function and fetal Doppler changes in healthy pregnancies and those with pre-eclampsia (PE), small for gestational age (SGA) or fetal growth restriction (FGR)....

Doppler cardiac output cardiovascular function fetal growth restriction pre-eclampsia

The 2005 banlieue uprisings were the most important acts of contestation in France since May 1968, yet unlike the earlier student protests, they were largely interpreted as aimless violence rather than political dissent. While...

banlieue Police justice discrimination narrative /dk/atira/pure/subjectarea/asjc/1200/1200 name=General Arts and Humanities /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions

The 2005 banlieue uprisings were the most important acts of contestation in France since May 1968, yet unlike the earlier student protests, they were largely interpreted as aimless violence rather than political dissent. While...

banlieue Police justice discrimination narrative /dk/atira/pure/subjectarea/asjc/1200/1200 name=General Arts and Humanities /dk/atira/pure/sustainabledevelopmentgoals/peace_justice_and_strong_institutions name=SDG 16 - Peace, Justice and Strong Institutions

DNA Methylation PM2.5 Asthma epigenetics Pregnancy wildfire Air Pollutants Air Pollution Child Child Preschool Environmental Exposure Epigenesis Genetic Female Fires Humans Pregnancy Smoke

Earth BioGenome Project ethics genome assembly Genomics Animals Base Sequence Biodiversity Eukaryota Genomics Humans Reference Standards Reference Values Sequence Analysis DNA

Abstract: Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2...

article /631/181/735 /631/181/757 /631/326/421 /692/699/255/2514 article

Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage -...

Africa Central Antibodies Neutralizing covid-19 Europe Humans Immune Evasion Mutation Phylogeny Phylogeography SARS-CoV-2 Spike Glycoprotein Coronavirus Travel