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Reward prediction error.
Wolfram Schultz
Feb 28, 2019
In this quick guide, Wolfram Schultz provides an introduction of reward prediction error, exploring the signal of dopamine neurons and describing its potential role in reward accumulation, decision-making and everyday life.
Wolfram syndrome
Wolfram Syndrome (WS) is an ultra-rare, progressive neurodegenerative disease characterized by early-onset diabetes mellitus and irreversible loss of vision, secondary to optic nerve degeneration. Visual loss in WS is...
A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions.
Cécile Rouzier, David Moore, Cécile Delorme, Sandra Lacas-Gervais, Samira Ait-El-Mkadem, Konstantina Fragaki, Florence Burté, Valérie Serre, Sylvie Bannwarth, Annabelle Chaussenot, Martin Catala, Patrick Yu-Wai-Man, Véronique Paquis-Flucklinger
Jun 28, 2018
Wolfram syndrome (WS) is a progressive neurodegenerative disease characterized by early-onset optic atrophy and diabetes mellitus, which can be associated with more extensive central nervous system and endocrine complications....
A mutant wfs1 zebrafish model of Wolfram syndrome manifesting visual dysfunction and developmental delay.
G Cairns, F Burté, R Price, E O'Connor, M Toms, R Mishra, M Moosajee, A Pyle, JA Sayer, P Yu-Wai-Man
Sep 29, 2021
Wolfram syndrome (WS) is an ultra-rare progressive neurodegenerative disorder defined by early-onset diabetes mellitus and optic atrophy. The majority of patients harbour recessive mutations in the WFS1 gene, which encodes for...
Is Tuition Free College the Golden Ticket? A Time Series Analysis of Germany's Higher Education Policy, 1990-2017
Hannah Wolfram
Jan 01, 0001
Countries which have been able to offer free tertiary education are being applauded while the United States tries to find a way to rectify its high tertiary education costs. Germany has accomplished a system of subsidized higher...
Free College Tertiary Education Subsidies Tertiary Unemployment Germany unemployment benefits First-Difference Model Business Economics Education Economics Higher Education International and Comparative Education Modern Languages secondary education
Published by: Ursinus College
WFS1 protein expression correlates with clinical progression of optic atrophy in patients with Wolfram syndrome.
Kun Hu, Malgorzata Zatyka, Dewi Astuti, Nicola Beer, Renuka P Dias, Archana Kulkarni, John Ainsworth, Benjamin Wright, Anna Majander, Patrick Yu-Wai-Man, Denise Williams, Timothy Barrett
May 21, 2021
BACKGROUND: Wolfram syndrome (WFS) is a rare disorder characterised by childhood-onset diabetes mellitus and progressive optic atrophy. Most patients have variants in the WFS1 gene. We undertook functional studies of WFS1...
Helicobacter pylori Eradication Therapy
Background. Though Helicobacter pylori (HP) infections have progressively declined throughout most of the industrialized countries, a gradual increase in failure of HP eradication treatments is observed. Aim. To critically...
Labile Photo‐Induced Free Radical in α‐Ketoglutaric Acid
Adam P Gaunt, Jennifer S Lewis, Friederike Hesse, Tian Cheng, Irene Marco‐Rius, Kevin M Brindle, Arnaud Comment
Dec 15, 2021
Abstract: Hyperpolarized (HP) 13C magnetic resonance enables non‐invasive probing of metabolism in vivo. To date, only 13C‐molecules hyperpolarized with persistent trityl radicals have been injected in humans. We show here that...
Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma-A Proof of Principle Study.
Stephan Ursprung, Ramona Woitek, Mary McLean, Andrew N Priest, Mireia Crispin-Ortuzar, Cara R Brodie, Andrew Gill, Marcel Gehrung, Lucian Beer, Antony CP Riddick, Johanna Field-Rayner, James T Grist, Surrin S Deen, Frank Riemer, Joshua Kaggie, Fulvio Zaccagna, Joao AG Duarte, Matthew J Locke, Amy Frary, Tevita F Aho, James N Armitage, Ruth Casey, Iosif A Mendichovszky, Sarah Welsh, Tristan Barrett, Martin Graves, Tim Eisen, Thomas J Mitchell, Anne Warren, Kevin Brindle, Evis Sala, Grant Stewart, Ferdia Gallagher
Jan 28, 2022
Differentiating aggressive clear cell renal cell carcinoma (ccRCC) from indolent lesions is challenging using conventional imaging. This work prospectively compared the metabolic imaging phenotype of renal tumors using carbon-13...
Retrospective evaluation of hyperproteinorrachia without pleocytosis (albuminocytologic dissociation) and survival in dogs.
BACKGROUND: Hyperproteinorrachia (raised cerebrospinal fluid total protein [CSF-TP]) without pleocytosis (HP) (also known as albuminocytologic dissociation) is identified in dogs with different neurologic diseases. However, the...
On the Hughes' model for pedestrian flow
In this paper we investigate the mathematical theory of Hughes' model for the flow of pedestrians (cf. Hughes (2002) [17]), consisting of a non-linear conservation law for the density of pedestrians coupled with an eikonal...
Functions of primate amygdala neurons in economic decisions and social decision simulation.
Long implicated in aversive processing, the amygdala is now recognized as a key component of the brain systems that process rewards. Beyond reward valuation, recent findings from single-neuron recordings in monkeys indicate that...
On the Hughes' model for pedestrian flow
In this paper we investigate the mathematical theory of Hughes' model for the flow of pedestrians (cf. Hughes (2002) [17]), consisting of a non-linear conservation law for the density of pedestrians coupled with an eikonal...
A Pili-Driven Bacterial Turbine
Work generated by self-propelled bacteria can be harnessed with the help of microdevices. Such nanofabricated microdevices, immersed in a bacterial bath, may exhibit unidirectional rotational or translational motion....
Atomistic Simulations of Methylammonium Lead Halide Layers on PbTiO<sub>3</sub> (001) Surfaces
Neculai Plugaru, George Alexandru Nemnes, Lucian Filip, Ioana Pintilie, Lucian Pintilie, Keith Tobias Butler, Andrei Manolescu
May 04, 2017
The substantial increase in the power conversion efficiency of hybrid perovskite solar cells, to date reaching more than 20% in the laboratory, has strongly motivated research on this class of organic-inorganic materials and...
/dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2100/2100 name=General Energy /dk/atira/pure/subjectarea/asjc/2500/2508 name=Surfaces, Coatings and Films /dk/atira/pure/subjectarea/asjc/1600/1606 name=Physical and Theoretical Chemistry
Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma-A Proof of Principle Study.
Stephan Ursprung, Ramona Woitek, Mary A McLean, Andrew N Priest, Mireia Crispin-Ortuzar, Cara R Brodie, Andrew B Gill, Marcel Gehrung, Lucian Beer, Antony CP Riddick, Johanna Field-Rayner, James T Grist, Surrin S Deen, Frank Riemer, Joshua D Kaggie, Fulvio Zaccagna, Joao AG Duarte, Matthew J Locke, Amy Frary, Tevita F Aho, James N Armitage, Ruth Casey, Iosif A Mendichovszky, Sarah J Welsh, Tristan Barrett, Martin J Graves, Tim Eisen, Thomas J Mitchell, Anne Y Warren, Kevin M Brindle, Evis Sala, Grant D Stewart, Ferdia A Gallagher
Feb 20, 2022
Differentiating aggressive clear cell renal cell carcinoma (ccRCC) from indolent lesions is challenging using conventional imaging. This work prospectively compared the metabolic imaging phenotype of renal tumors using carbon-13...
First-in-human in vivo non-invasive assessment of intra-tumoral metabolic heterogeneity in renal cell carcinoma.
Maxine Tran, Arash Latifoltojar, Joana B Neves, Marianthi-Vasiliki Papoutsaki, Fiona Gong, Arnaud Comment, Ana SH Costa, Matthias Glaser, My-Anh Tran-Dang, Soha El Sheikh, Wivijin Piga, Alan Bainbridge, Anna Barnes, Tim Young, Hassan Jeraj, Ramla Awais, Sola Adeleke, Christopher Holt, James O'Callaghan, Frazer Twyman, David Atkinson, Christian Frezza, Erik Årstad, David Gadian, Mark Emberton, Shonit Punwani
Feb 22, 2019
Intratumoral genetic heterogeneity and the role of metabolic reprogramming in renal cell carcinoma (RCC) have been extensively documented. However, the distribution of these metabolic changes within the tissue has not been...
2022 roadmap on neuromorphic computing and engineering
Dennis V Christensen, Regina Dittmann, Bernabe Linares-Barranco, Abu Sebastian, Manuel Le Gallo, Andrea Redaelli, Stefan Slesazeck, Thomas Mikolajick, Sabina Spiga, Stephan Menzel, Ilia Valov, Gianluca Milano, Carlo Ricciardi, Shi-Jun Liang, Feng Miao, Mario Lanza, Tyler J Quill, Scott Keene, Alberto Salleo, Julie Grollier, Danijela Marković, Alice Mizrahi, Peng Yao, J Joshua Yang, Giacomo Indiveri, John Paul Strachan, Suman Datta, Elisa Vianello, Alexandre Valentian, Johannes Feldmann, Xuan Li, Wolfram HP Pernice, Harish Bhaskaran, Steve Furber, Emre Neftci, Franz Scherr, Wolfgang Maass, Srikanth Ramaswamy, Jonathan Tapson, Priyadarshini Panda, Youngeun Kim, Gouhei Tanaka, Simon Thorpe, Chiara Bartolozzi, Thomas A Cleland, Christoph Posch, ShihChii Liu, Gabriella Panuccio, Mufti Mahmud, Arnab Neelim Mazumder, Morteza Hosseini, Tinoosh Mohsenin, Elisa Donati, Silvia Tolu, Roberto Galeazzi, Martin Ejsing Christensen, Sune Holm, Daniele Ielmini, N Pryds
Jun 07, 2022
Planning activity for internally generated reward goals in monkey amygdala neurons.
The best rewards are often distant and can only be achieved by planning and decision-making over several steps. We designed a multi-step choice task in which monkeys followed internal plans to save rewards toward self-defined...
Orbitofrontal signals for two-component choice options comply with indifference curves of Revealed Preference Theory
Abstract: Economic choice options contain multiple components and constitute vectorial bundles. The question arises how they are represented by single-dimensional, scalar neuronal signals that are suitable for economic...
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