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Reward prediction error.
Wolfram Schultz
Feb 28, 2019
In this quick guide, Wolfram Schultz provides an introduction of reward prediction error, exploring the signal of dopamine neurons and describing its potential role in reward accumulation, decision-making and everyday life.
Of Cell Shapes and Motion
Motile cells have developed a variety of migration modes relying on diverse traction-force-generation mechanisms. Before the behavior of intracellular components could be easily imaged, cell movements were mostly classified by...
Single-cell morphometrics reveals ancestral principles of notochord development.
Toby GR Andrews, Wolfram Pönisch, Ewa K Paluch, Benjamin J Steventon, Elia Benito-Gutierrez
Jul 23, 2021
Wolfram syndrome
Wolfram Syndrome (WS) is an ultra-rare, progressive neurodegenerative disease characterized by early-onset diabetes mellitus and irreversible loss of vision, secondary to optic nerve degeneration. Visual loss in WS is...
A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions.
Cécile Rouzier, David Moore, Cécile Delorme, Sandra Lacas-Gervais, Samira Ait-El-Mkadem, Konstantina Fragaki, Florence Burté, Valérie Serre, Sylvie Bannwarth, Annabelle Chaussenot, Martin Catala, Patrick Yu-Wai-Man, Véronique Paquis-Flucklinger
Jun 28, 2018
Wolfram syndrome (WS) is a progressive neurodegenerative disease characterized by early-onset optic atrophy and diabetes mellitus, which can be associated with more extensive central nervous system and endocrine complications....
A mutant wfs1 zebrafish model of Wolfram syndrome manifesting visual dysfunction and developmental delay.
G Cairns, F Burté, R Price, E O'Connor, M Toms, R Mishra, M Moosajee, A Pyle, JA Sayer, P Yu-Wai-Man
Sep 29, 2021
Wolfram syndrome (WS) is an ultra-rare progressive neurodegenerative disorder defined by early-onset diabetes mellitus and optic atrophy. The majority of patients harbour recessive mutations in the WFS1 gene, which encodes for...
Is Tuition Free College the Golden Ticket? A Time Series Analysis of Germany's Higher Education Policy, 1990-2017
Hannah Wolfram
Jan 01, 0001
Countries which have been able to offer free tertiary education are being applauded while the United States tries to find a way to rectify its high tertiary education costs. Germany has accomplished a system of subsidized higher...
Free College Tertiary Education Subsidies Tertiary Unemployment Germany unemployment benefits First-Difference Model Business Economics Education Economics Higher Education International and Comparative Education Modern Languages secondary education
Published by: Ursinus College
WFS1 protein expression correlates with clinical progression of optic atrophy in patients with Wolfram syndrome.
Kun Hu, Malgorzata Zatyka, Dewi Astuti, Nicola Beer, Renuka P Dias, Archana Kulkarni, John Ainsworth, Benjamin Wright, Anna Majander, Patrick Yu-Wai-Man, Denise Williams, Timothy Barrett
May 21, 2021
BACKGROUND: Wolfram syndrome (WFS) is a rare disorder characterised by childhood-onset diabetes mellitus and progressive optic atrophy. Most patients have variants in the WFS1 gene. We undertook functional studies of WFS1...
On the Hughes' model for pedestrian flow
In this paper we investigate the mathematical theory of Hughes' model for the flow of pedestrians (cf. Hughes (2002) [17]), consisting of a non-linear conservation law for the density of pedestrians coupled with an eikonal...
Functions of primate amygdala neurons in economic decisions and social decision simulation.
Long implicated in aversive processing, the amygdala is now recognized as a key component of the brain systems that process rewards. Beyond reward valuation, recent findings from single-neuron recordings in monkeys indicate that...
On the Hughes' model for pedestrian flow
In this paper we investigate the mathematical theory of Hughes' model for the flow of pedestrians (cf. Hughes (2002) [17]), consisting of a non-linear conservation law for the density of pedestrians coupled with an eikonal...
A Pili-Driven Bacterial Turbine
Work generated by self-propelled bacteria can be harnessed with the help of microdevices. Such nanofabricated microdevices, immersed in a bacterial bath, may exhibit unidirectional rotational or translational motion....
Planning activity for internally generated reward goals in monkey amygdala neurons.
The best rewards are often distant and can only be achieved by planning and decision-making over several steps. We designed a multi-step choice task in which monkeys followed internal plans to save rewards toward self-defined...
Orbitofrontal signals for two-component choice options comply with indifference curves of Revealed Preference Theory
Abstract: Economic choice options contain multiple components and constitute vectorial bundles. The question arises how they are represented by single-dimensional, scalar neuronal signals that are suitable for economic...
Adaptation of utility functions to reward distribution in rhesus monkeys.
This study investigated how the experience of different reward distributions would shape the utility functions that can be inferred from economic choice. Despite the generally accepted notion that utility functions are not...
Reward functions of the basal ganglia.
Wolfram Schultz
Dec 16, 2019
Besides their fundamental movement function evidenced by Parkinsonian deficits, the basal ganglia are involved in processing closely linked non-motor, cognitive and reward information. This review describes the reward functions...
Predictive coding of the statistical parameters of uncertain rewards by orbitofrontal neurons.
Monkeys choose as if maximizing utility compatible with basic principles of revealed preference theory.
Revealed preference theory provides axiomatic tools for assessing whether individuals make observable choices "as if" they are maximizing an underlying utility function. The theory evokes a tradeoff between goods whereby...
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