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Functional connexin35 increased in the myopic chicken retina.
Seema Banerjee, Qing Wang, George Tang, Chunghim So, Sze Wan Shan, King Kit Li, Chi-Wai Do, Feng Pan
Jun 14, 2021
Our previous research showed that increased phosphorylation of connexin (Cx)36 indicated extended coupling of AII amacrine cells (ACs) in the rod-dominant mouse myopic retina. This research will determine whether...
Airway secretory cell fate conversion via YAP‐mTORC1‐dependent essential amino acid metabolism
Hae Yon Jeon, Jinwook Choi, Lianne Kraaier, Young Hoon Kim, David Eisenbarth, Kijong Yi, Ju‐Gyeong Kang, Jin Woo Kim, Hyo Sup Shim, Joo‐Hyeon Lee, Dae‐Sik Lim
Mar 14, 2022
One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs
Esther C. Y. Woon, Peter T. Sunderland, Helen A. Paine, Matthew D. Lloyd, Andrew S. Thompson, Michael D. Threadgill
Sep 01, 2013
Poly(ADP-ribose)polymerase-1 (PARP-1) is an important target for drug design for several therapeutic applications. 5-Aminoisoquinolin-1-one (5-AIQ) is a highly water-soluble lead compound; synthetic routes to 3-substituted...
One-pot tandem Hurtley–retro-Claisen–cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs
Esther C. Y. Woon, Peter T. Sunderland, Helen A. Paine, Matthew D. Lloyd, Andrew S. Thompson, Michael D. Threadgill
Sep 01, 2013
Poly(ADP-ribose)polymerase-1 (PARP-1) is an important target for drug design for several therapeutic applications. 5-Aminoisoquinolin-1-one (5-AIQ) is a highly water-soluble lead compound; synthetic routes to 3-substituted...
A global analysis of the impact of COVID-19 stay-at-home restrictions on crime
Amy E. Nivette, Renee Zahnow, Raul Aguilar, Andri Ahven, Shai Amram, Barak Ariel, María José Arosemena Burbano, Roberta Astolfi, Dirk Baier, Hyung-Min Bark, Joris E. H. Beijers, Marcelo Bergman, Gregory Breetzke, I. Alberto Concha-Eastman, Sophie Curtis-Ham, Ryan Davenport, Carlos Díaz, Diego Fleitas, Manne Gerell, Kwang-Ho Jang, Juha Kääriäinen, Tapio Lappi-Seppälä, Woon-Sik Lim, Rosa Loureiro Revilla, Lorraine Mazerolle, Gorazd Meško, Noemí Pereda, Maria F. T. Peres, Rubén Poblete-Cazenave, Simon Rose, Robert Svensson, Nico Trajtenberg, Tanja van der Lippe, Joran Veldkamp, Carlos J. Vilalta Perdomo, Manuel P. Eisner
Jul 28, 2021
A global analysis of the impact of COVID-19 stay-at-home restrictions on crime.
Amy E Nivette, Renee Zahnow, Raul Aguilar, Andri Ahven, Shai Amram, Barak Ariel, María José Arosemena Burbano, Roberta Astolfi, Dirk Baier, Hyung-Min Bark, Joris EH Beijers, Marcelo Bergman, Gregory Breetzke, I Alberto Concha-Eastman, Sophie Curtis-Ham, Ryan Davenport, Carlos Díaz, Diego Fleitas, Manne Gerell, Kwang-Ho Jang, Juha Kääriäinen, Tapio Lappi-Seppälä, Woon-Sik Lim, Rosa Loureiro Revilla, Lorraine Mazerolle, Gorazd Meško, Noemí Pereda, Maria FT Peres, Rubén Poblete-Cazenave, Simon Rose, Robert Svensson, Nico Trajtenberg, Tanja van der Lippe, Joran Veldkamp, Carlos J Vilalta Perdomo, Manuel P Eisner
Jun 22, 2021
Online Prediction via Continuous Artificial Prediction Markets
Fatemeh Jahedpari, Talal Rahwan, Sattar Hashemi, Tomasz P Michalak, Marina De Vos, Julian Padget, Wei Lee Woon
Feb 13, 2017
Prediction markets are well-established tools for aggregating information from diverse sources into accurate forecasts. Their success has been demonstrated in a wide range applications, including presidential campaigns, sporting...
Unleashing Continuous Improvement and Competitive Advantage Through BP-Driven Knowledge Management Processes
The knowledge management process (KMP) requires continuous enhancement and is closely intertwined with the corresponding organizational business processes (BPs). Despite efforts to improve the integration of KMP and BPs, many...
Published by: IGI Global Scientific Publishing
The effect of crystal structure on the electromechanical properties of piezoelectric Nylon-11 nanowires.
Yeon Sik Choi, Sung Kyun Kim, Findlay Williams, Yonatan Calahorra, James A Elliott, Sohini Kar-Narayan
Aug 16, 2018
Crystal structure is crucial in determining the properties of piezoelectric polymers, particularly at the nanoscale where precise control of the crystalline phase is possible. Here, we investigate the electromechanical...
Online Prediction via Continuous Artificial Prediction Markets
Fatemeh Jahedpari, Talal Rahwan, Sattar Hashemi, Tomasz P Michalak, Marina De Vos, Julian Padget, Wei Lee Woon
Feb 13, 2017
Prediction markets are well-established tools for aggregating information from diverse sources into accurate forecasts. Their success has been demonstrated in a wide range applications, including presidential campaigns, sporting...
Hydrodynamic voltammetry at a rocking disc electrode
Sunyhik D. Ahn, Karthik Somasundaram, H. Viet Nguyen, Erik Birgersson, Jim Yang Lee, Xiangming Gao, Adrian C. Fisher, Paul E. Frith, Frank Marken
Jan 10, 2016
Rocking disc electrode voltammetry (RoDE) is introduced as an experimentally convenient and versatile alternative to rotating disc voltammetry. A 1.6 mm diameter disc electrode is employed with an overall rocking angle of θ =...
Hydrodynamic voltammetry at a rocking disc electrode
Sunyhik D. Ahn, Karthik Somasundaram, H. Viet Nguyen, Erik Birgersson, Jim Yang Lee, Xiangming Gao, Adrian C. Fisher, Paul E. Frith, Frank Marken
Jan 10, 2016
Rocking disc electrode voltammetry (RoDE) is introduced as an experimentally convenient and versatile alternative to rotating disc voltammetry. A 1.6 mm diameter disc electrode is employed with an overall rocking angle of θ =...
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors <em>in vitro</em>
Helen A. Paine, Amit Nathubhai, Esther C. Y. Woon, Peter T. Sunderland, Pauline J. Wood, Mary F. Mahon, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Mohit Narwal, Lari Lehtio, Michael D. Threadgill
Sep 01, 2015
Tankyrases-1 and -2 (TNKS-1 and TNKS-2) have three cellular roles which make them important targets in cancer. Using NAD+ as a substrate, they poly(ADP-ribosyl)ate TRF1 (regulating lengths of telomeres), NuMA...
Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models
Peh Joo Ho, Weang Kee Ho, Alexis J Khng, Yen Shing Yeoh, Benita Kiat-Tee Tan, Ern Yu Tan, Geok Hoon Lim, Su-Ming Tan, Veronique Kiak Mien Tan, Cheng-Har Yip, Nur-Aishah Mohd-Taib, Fuh Yong Wong, Elaine Hsuen Lim, Joanne Ngeow, Wen Yee Chay, Lester Chee Hao Leong, Wei Sean Yong, Chin Mui Seah, Siau Wei Tang, Celene Wei Qi Ng, Zhiyan Yan, Jung Ah Lee, Kartini Rahmat, Tania Islam, Tiara Hassan, Mei-Chee Tai, Chiea Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Xueling Sim, Alison M Dunning, Manjeet K Bolla, Antonis C Antoniou, Soo-Hwang Teo, Jingmei Li, Mikael Hartman
May 27, 2022
BACKGROUND: Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. METHODS...
Appropriate(d) nursery reading; or, Charles Lamb’s (implied) child reader and the adaptation of ‘adult’ fiction for the Godwins’ Juvenile Library
Jessica Lim
Mar 17, 2016
One does not have to look hard to find the British Romantics’ anxiety concerning early nineteenth-century children’s booksor scholarly debates about Romanticism and children’s literature. Often brandished about in this fray is...
Slippery Moral Messages and Political Pedagogues
Jessica WH Lim
Oct 03, 2016
The accepted narrative of the eighteenth-century English fable is one of peak and decline. Fable scholars (already scant in number) tend to associate the politicized Augustan fable with the political turmoil surrounding the...
A Niche for Adult Neurogenesis: Analysis of BMP Signaling and Transcriptional Profiles of Adult Subventricular Zone Cells
Daniel A Lim
Jan 01, 0001
Neurogenesis persists in restricted regions of the adult vertebrate brain. The largest region of adult neurogenesis is the subventricular zone (SVZ) of the lateral ventricle wall. Neural stem cells reside in the SVZ. The S V Z...
Published by: Rockefeller University
Skin models for cutaneous melioidosis reveal Burkholderia infection dynamics at wound's edge with inflammasome activation, keratinocyte extrusion and epidermal detachment.
Joanne Wei Kay Ku, Supatra Tharinee Marsh, Mui Hoon Nai, Kim Samirah Robinson, Daniel Eng Thiam Teo, Franklin Lei Zhong, Katherine A Brown, Thiam Chye Lim, Chwee Teck Lim, Yunn-Hwen Gan
Jan 07, 2022
5-benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2)
Peter T Sunderland, Esther C Y Woon, Archana Dhami, Aoife B Bergin, Mary F Mahon, Pauline J Wood, Louise A Jones, Sophie R Tully, Matthew D Lloyd, Andrew S Thompson, Hashim Javaid, Niall M B Martin, Michael D Threadgill
Jan 01, 0001
PARP-2 is a member of the poly(ADP-ribose) polymerase family, with some activities similar to those of PARP-1 but with other distinct roles. Two series of isoquinolin-1-ones were designed, synthesized, and evaluated as selective...
A semilinear elliptic equation with competing powers and a radial potential
We verify the existence of radial positive solutions for the semilinear equation (Formula presented.) where N ≥ 3, p is close to p* ≔ (N+ 2)/(N − 2), and V is a radial smooth potential. If q is super-critical, namely q >...
Detecting and quantifying insider trading and stock manipulation in Asian markets
This paper focuses on insider trading, where the perpetrators exploit market sensitive information to earn profits or avoid losses. The paper's objectives are as follows. First, we seek to examine whether we can detect possible...
A semilinear elliptic equation with competing powers and a radial potential
We verify the existence of radial positive solutions for the semilinear equation (Formula presented.) where N ≥ 3, p is close to p* ≔ (N+ 2)/(N − 2), and V is a radial smooth potential. If q is super-critical, namely q >...
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