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Results: 90
Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models.
Gertjan Kramer, Wouter Wegdam, Wilma Donker-Koopman, Roelof Ottenhoff, Paulo Gaspar, Marri Verhoek, Jessica Nelson, Tanit Gabriel, Wouter Kallemeijn, Rolf G Boot, Jon D Laman, Johannes PC Vissers, Timothy Cox, Elena Pavlova, Mary Teresa Moran, Johannes M Aerts, Marco van Eijk
Feb 18, 2019
Gaucher disease is caused by inherited deficiency of lysosomal glucocerebrosidase. Proteome analysis of laser-dissected splenic Gaucher cells revealed increased amounts of glycoprotein nonmetastatic melanoma protein B (gpNMB)....
Behaviour change to address climate change
Addressing climate change requires profound behaviour change, not only in consumer action, but also in action as members of communities and organisations, and as citizens who can influence policies. However, while many...
Behaviour change to address climate change
Addressing climate change requires profound behaviour change, not only in consumer action, but also in action as members of communities and organisations, and as citizens who can influence policies. However, while many...
Historical flood events in Europe
The purpose of this ETC/ICM Technical Report is to support the discussion on the practices of reporting for the preliminary flood risk assessment (PFRA). The focus is on the economic and environmental impacts of flooding. This...
Explaining intention to reduce red and processed meat in the UK and Italy using the theory of planned behaviour, meat-eater identity, and the Transtheoretical model
Emily Wolstenholme, Valentina Carfora, Patrizia Catellani, Wouter Poortinga, Lorraine Whitmarsh
Nov 01, 2021
This study aimed to contribute to the growing literature investigating the psychosocial factors associated with intentions to reduce red and processed meat consumption, given the significant negative impact of meat on public...
behavior change Cross-national comparison Meat consumption Meat-eater identity theory of planned behavior TRANSTHEORETICAL MODEL /dk/atira/pure/subjectarea/asjc/3200/3200 name=General Psychology /dk/atira/pure/subjectarea/asjc/2900/2916 name=Nutrition and Dietetics /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Explaining intention to reduce red and processed meat in the UK and Italy using the theory of planned behaviour, meat-eater identity, and the Transtheoretical model
Emily Wolstenholme, Valentina Carfora, Patrizia Catellani, Wouter Poortinga, Lorraine Whitmarsh
Nov 01, 2021
This study aimed to contribute to the growing literature investigating the psychosocial factors associated with intentions to reduce red and processed meat consumption, given the significant negative impact of meat on public...
behavior change Cross-national comparison Meat consumption Meat-eater identity theory of planned behavior TRANSTHEORETICAL MODEL /dk/atira/pure/subjectarea/asjc/3200/3200 name=General Psychology /dk/atira/pure/subjectarea/asjc/2900/2916 name=Nutrition and Dietetics /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being /dk/atira/pure/sustainabledevelopmentgoals/climate_action name=SDG 13 - Climate Action
Historical flood events in Europe
The purpose of this ETC/ICM Technical Report is to support the discussion on the practices of reporting for the preliminary flood risk assessment (PFRA). The focus is on the economic and environmental impacts of flooding. This...
The connection between subjective wellbeing and pro-environmental behaviour
Stuart Capstick, Nicholas Nash, Lorraine Whitmarsh, Wouter Poortinga, Paul Haggar, Adrian Brügger
Jul 31, 2022
A positive and reciprocal relationship between subjective wellbeing and pro-environmental behaviour (PEB) has been observed across a range of countries worldwide. There is good reason however to think that the nature of the...
Cross-cultural materialism motivations Pro-environmental behaviour values Wellbeing /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
The connection between subjective wellbeing and pro-environmental behaviour
Stuart Capstick, Nicholas Nash, Lorraine Whitmarsh, Wouter Poortinga, Paul Haggar, Adrian Brügger
Jul 31, 2022
A positive and reciprocal relationship between subjective wellbeing and pro-environmental behaviour (PEB) has been observed across a range of countries worldwide. There is good reason however to think that the nature of the...
Cross-cultural materialism motivations Pro-environmental behaviour values Wellbeing /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/2300/2308 name=Management, Monitoring, Policy and Law /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants.
Peter Willeit, Paul Welsh, Jonathan DW Evans, Lena Tschiderer, Charles Boachie, J Wouter Jukema, Ian Ford, Stella Trompet, David J Stott, Patricia M Kearney, Simon P Mooijaart, Stefan Kiechl, Emanuele Di Angelantonio, Naveed Sattar
Nov 16, 2018
BACKGROUND: High-sensitivity assays can quantify cardiac troponins I and T (hs-cTnI, hs-cTnT) in individuals with no clinically manifest myocardial injury. OBJECTIVES: The goal of this study was to assess associations of cardiac...
Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48
SP Jackson, Georgia Velimezi, Lydia Robinson-Garcia, Francisco Muñoz-Martínez, Wouter Wiegant, Joana Ferreira da Silva, Michel Owusu, Martin Moder, Marc Wiedner, Sara Rosenthal, Kathleen Fisch, Jason Moffat, Jörg Menche, Haico Van Attikum, Joanna Loizou
Sep 25, 2018
Defects in DNA repair can cause various genetic diseases with severe pathological phenotypes. Fanconi anemia (FA) is a rare disease characterized by bone marrow failure, developmental abnormalities and increased cancer risk that...
When Time Is Critical, Is Informed Consent Less So? A Discussion of Patient Autonomy in Emergency Neurosurgery.
Ivo S Muskens, Saksham Gupta, Faith C Robertson, Wouter A Moojen, Angelos G Kolias, Wilco C Peul, Marike LD Broekman
Feb 06, 2019
Neurosurgical interventions frequently occur in an emergency setting. In this setting, patients often have impaired consciousness and are unable to directly express their values and wishes regarding their treatment. The limited...
Synthetic long peptide booster immunization in rhesus macaques primed with replication-competent NYVAC-C-KC induces a balanced CD4/CD8 T-cell and antibody response against the conserved regions of HIV-1.
Petra Mooij, Gerrit Koopman, Jan Wouter Drijfhout, Ivonne G Nieuwenhuis, Niels Beenhakker, Josef Koestler, Willy MJM Bogers, Ralf Wagner, Mariano Esteban, Giuseppe Pantaleo, Jonathan L Heeney, Bertram L Jacobs, Cornelis JM Melief
Jun 11, 2015
Skull base repair following endonasal pituitary and skull base tumour resection
Danyal Z Khan, Ahmad MS Ali, Chan Hee Koh, Neil L Dorward, Joan Grieve, Hugo Layard Horsfall, William Muirhead, Thomas Santarius, Wouter R Van Furth, Amir H Zamanipoor Najafabadi, Hani J Marcus
Sep 03, 2021
PURPOSE: Postoperative cerebrospinal fluid rhinorrhoea (CSFR) remains a frequent complication of endonasal approaches to pituitary and skull base tumours. Watertight skull base reconstruction is important in preventing CSFR. We...
CSF cerebrospinal fluid Cerebrospinal Fluid Leak Cerebrospinal fluid rhinorrhoea Endoscopic endonasal Endoscopic transsphenoidal surgery Skull base surgery Cerebrospinal Fluid Leak Cerebrospinal Fluid Rhinorrhea endoscopy Humans Postoperative Complications Retrospective Studies Skull Base Skull Base Neoplasms
A MT-TL1 variant identified by whole exome sequencing in an individual with intellectual disability, epilepsy, and spastic tetraparesis.
Elke de Boer, Charlotte W Ockeloen, Leslie Matalonga, Rita Horvath, Solve-RD SNV-indel working group, Richard J Rodenburg, Marieke JH Coenen, Mirian Janssen, Dylan Henssen, Christian Gilissen, Wouter Steyaert, Ida Paramonov, Solve-RD-DITF-ITHACA, Aurélien Trimouille, Tjitske Kleefstra, Alain Verloes, Lisenka ELM Vissers
Sep 24, 2021
Splice-Modulating Oligonucleotide QR-110 Restores CEP290 mRNA and Function in Human c.2991+1655A>G LCA10 Models.
Kalyan Dulla, Monica Aguila, Amelia Lane, Katarina Jovanovic, David A Parfitt, Iris Schulkens, Hee Lam Chan, Iris Schmidt, Wouter Beumer, Lars Vorthoren, Rob WJ Collin, Alejandro Garanto, Lonneke Duijkers, Anna Brugulat-Panes, Ma'ayan Semo, Anthony A Vugler, Patricia Biasutto, Peter Adamson, Michael E Cheetham
Aug 07, 2019
Implementation of functional imaging using 11C-methionine PET-CT co-registered with MRI for advanced surgical planning and decision making in prolactinoma surgery.
Leontine EH Bakker, Marco JT Verstegen, Eidrees Ghariq, Berit M Verbist, Pieter J Schutte, Waiel A Bashari, Mark C Kruit, Alberto M Pereira, Mark Gurnell, Nienke R Biermasz, Wouter R Van Furth, Lenka M Pereira Arias Bouda
Aug 02, 2022
PURPOSE: To report the first experience of our multidisciplinary team with functional imaging using 11C-methionine positron emission tomography-computed tomography (11C-methionine PET-CT) co-registered with MRI (Met-PET/MRICR)...
Dopamine agonist intolerance functional imaging positron emission tomography Prolactinoma Surgical decision making Transsphenoidal surgery Decision Making Humans Magnetic Resonance Imaging Methionine Pituitary Neoplasms Positron Emission Tomography Computed Tomography Positron-Emission Tomography Prolactinoma Retrospective Studies
Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2.
Xin-Ran Li, Jongho Sun, Doris Albinsky, Darius Zarrabian, Raphaella Hull, Tak Lee, Edwin Jarratt-Barnham, Chai Hao Chiu, Amy Jacobsen, Eleni Soumpourou, Alessio Albanese, Wouter Kohlen, Leonie H Luginbuehl, Bruno Guillotin, Tom Lawrensen, Hui Lin, Jeremy Murray, Emma Wallington, Wendy Harwood, Jeongmin Choi, Uta Paszkowski, Giles ED Oldroyd
Nov 28, 2022
Many plants associate with arbuscular mycorrhizal fungi for nutrient acquisition, while legumes also associate with nitrogen-fixing rhizobial bacteria. Both associations rely on symbiosis signaling and here we show that cereals...
Novel Insights Into Rheumatoid Arthritis Through Characterization of Concordant Changes in DNA Methylation and Gene Expression in Synovial Biopsies of Patients With Differing Numbers of Swollen Joints.
Andrew YF Li Yim, Enrico Ferrero, Klio Maratou, Huw D Lewis, George Royal, David F Tough, Chris Larminie, Marcel MAM Mannens, Peter Henneman, Wouter J de Jonge, Marleen GH van de Sande, Danielle M Gerlag, Rab K Prinjha, Paul P Tak
May 06, 2021
In this study, we sought to characterize synovial tissue obtained from individuals with arthralgia and disease-specific auto-antibodies and patients with established rheumatoid arthritis (RA), by applying an integrative...
DNA Methylation Arthralgia multi-omics analyses rheumatoid arthritis synovial biopsies target identification transcriptomics Adult Aged Aged 80 and over Arthralgia Arthritis Rheumatoid Arthroscopy Biopsy DNA Methylation Epigenesis Genetic Female Humans Male Middle Aged RNA-seq Severity of Illness Index Synovial Membrane whole genome sequencing Young Adult
Genomic signals of migration and continuity in Britain before the Anglo-Saxons.
Rui Martiniano, Anwen Caffell, Malin Holst, Kurt Hunter-Mann, Janet Montgomery, Gundula Müldner, Russell L McLaughlin, Matthew D Teasdale, Wouter Van Rheenen, Jan H Veldink, Leonard H Van den Berg, Orla Hardiman, Maureen Carroll, Steve Roskams, John Oxley, Colleen Morgan, Mark G Thomas, Ian Barnes, Christine McDonnell, Matthew J Collins, Daniel G Bradley
Nov 22, 2018
The purported migrations that have formed the peoples of Britain have been the focus of generations of scholarly controversy. However, this has not benefited from direct analyses of ancient genomes. Here we report nine ancient...
Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2.
Xin-Ran Li, Jongho Sun, Doris Albinsky, Darius Zarrabian, Raphaella Hull, Tak Lee, Edwin Jarratt-Barnham, Chai Hao Chiu, Amy Jacobsen, Eleni Soumpourou, Alessio Albanese, Wouter Kohlen, Leonie H Luginbuehl, Bruno Guillotin, Tom Lawrensen, Hui Lin, Jeremy Murray, Emma Wallington, Wendy Harwood, Jeongmin Choi, Uta Paszkowski, Giles ED Oldroyd
Oct 28, 2022
Many plants associate with arbuscular mycorrhizal fungi for nutrient acquisition, while legumes also associate with nitrogen-fixing rhizobial bacteria. Both associations rely on symbiosis signaling and here we show that cereals...
Mobile PEAR transcription factors integrate positional cues to prime cambial growth.
Shunsuke Miyashima, Pawel Roszak, Iris Sevilem, Koichi Toyokura, Bernhard Blob, Jung-Ok Heo, Nathan Mellor, Hanna Help-Rinta-Rahko, Sofia Otero, Wouter Smet, Mark Boekschoten, Guido Hooiveld, Kayo Hashimoto, Ondřej Smetana, Riccardo Siligato, Eva-Sophie Wallner, Ari Pekka Mähönen, Yuki Kondo, Charles W Melnyk, Thomas Greb, Keiji Nakajima, Rosangela Sozzani, Anthony Bishopp, Bert De Rybel, Ykä Helariutta
Feb 06, 2019
Neurosurgical procedures performed during residency in Europe-preliminary numbers and time trends.
Martin N Stienen, Jiri Bartek, Marcus A Czabanka, Christian F Freyschlag, Angelos Kolias, Sandro M Krieg, Wouter Moojen, Mirjam Renovanz, Nicolas Sampron, Sasan D Adib, Gerrit A Schubert, Andreas K Demetriades, Florian Ringel, Luca Regli, Karl Schaller, Torstein R Meling, EANS Young Neurosurgeons and EANS Training Committee
Mar 08, 2019
BACKGROUND: Differences in the postgraduate training programs of neurosurgical residents are suspected throughout Europe. The influence of working hour restrictions by the European Working Time Directive (WTD) 2003/88/EC on the...
Liver Transplantation for Acute Intermittent Porphyria.
Mattias Lissing, Greg Nowak, René Adam, Vincent Karam, Alexander Boyd, Laurent Gouya, Wouter Meersseman, Espen Melum, Urszula Ołdakowska-Jedynak, Florian P Reiter, Jordi Colmenero, Rosario Sanchez, Uta Herden, Janneke Langendonk, Paolo Ventura, Helena Isoniemi, Olivier Boillot, Felix Braun, Stéphanie Perrodin, Elizabeth Mowlem, Staffan Wahlin, European Liver and Intestine Transplant Association
Apr 21, 2021
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