A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans.
Hugo Zeberg,
Michael Dannemann,
Kristoffer Sahlholm,
Kristin Tsuo,
Tomislav Maricic,
Victor Wiebe,
Wulf Hevers,
Hugh PC Robinson,
Janet Kelso,
Svante Pääbo
Aug 03, 2020
The sodium channel Nav1.7 is crucial for impulse generation and conduction in peripheral pain pathways [1]. In Neanderthals, the Nav1.7 protein carried three amino acid substitutions (M932L, V991L, and D1908G) relative to modern...