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Results: 665
Realizing the classical XY Hamiltonian in polariton simulators.
Natalia G Berloff, Matteo Silva, Kirill Kalinin, Alexis Askitopoulos, Julian D Töpfer, Pasquale Cilibrizzi, Wolfgang Langbein, Pavlos G Lagoudakis
Sep 03, 2019
The vast majority of real-life optimization problems with a large number of degrees of freedom are intractable by classical computers, since their complexity grows exponentially fast with the number of variables. Many of these...
Pressure-stabilized divalent ozonide CaO3 and its impact on Earth's oxygen cycles.
Yanchao Wang, Meiling Xu, Liuxiang Yang, Bingmin Yan, Qin Qin, Xuecheng Shao, Yunwei Zhang, Dajian Huang, Xiaohuan Lin, Jian Lv, Dongzhou Zhang, Huiyang Gou, Ho-Kwang Mao, Changfeng Chen, Yanming Ma
Nov 16, 2020
High pressure can drastically alter chemical bonding and produce exotic compounds that defy conventional wisdom. Especially significant are compounds pertaining to oxygen cycles inside Earth, which hold key to understanding...
A Single-Center, Observational Study of 607 Children and Young People Presenting With Differences of Sex Development (DSD).
Elim Man, Imran Mushtaq, Angela Barnicoat, Polly Carmichael, Claire R Hughes, Kate Davies, Helen Aitkenhead, Rakesh Amin, Charles R Buchanan, Abraham Cherian, Nikola J Costa, Sarah M Creighton, Patrick G Duffy, Emma Hewson, Peter C Hindmarsh, Louisa C Monzani, Catherine J Peters, Philip G Ransley, Naima Smeulders, Helen A Spoudeas, Dan Wood, Ieuan A Hughes, Harshini Katugampola, Caroline E Brain, Mehul T Dattani, John C Achermann
Dec 24, 2022
CONTEXT: Differences of sex development (DSD) represent a wide range of conditions presenting at different ages to various health professionals. Establishing a diagnosis, supporting the family, and developing a management plan...
Genetic sex determination of mice by simplex PCR.
Simon James Tunster
Nov 07, 2018
BACKGROUND: Investigating fetal development in mice necessitates the determination of fetal sex. However, whilst the sex of adult and juvenile mice can be readily distinguished from anogenital distance, the sex of fetal and...
Intra- and inter-chromosomal interactions correlate with CTCF binding genome wide.
A prime goal in systems biology is the comprehensive use of existing high-throughput genomic datasets to gain a better understanding of chromatin organization and genome function. In this report, we use chromatin...
Power, false discovery rate and Winner's Curse in eQTL studies.
Investigation of the genetic architecture of gene expression traits has aided interpretation of disease and trait-associated genetic variants; however, key aspects of expression quantitative trait loci (eQTL) study design and...
Steady states of a driven dissipative dipolar XXZ chain
We study theoretically a driven dissipative one-dimensional XXZ spin$-1/2$
chain with dipole coupling and a tunable strength of the Ising and XY
interaction. Within a mean-field approximation, we find a rich phase diagram
with...
Genetic sex determination of mice by simplex PCR
Simon J Tunster
Oct 18, 2017
Abstract
Background
Investigating fetal development in mice necessitates the determination of fetal sex. However, whilst the sex of adult and juvenile mice can be readily...
MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.
Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.
Double-stranded RNA (dsRNA) is a potent proinflammatory signature of viral infection. Long cytosolic dsRNA is recognized by MDA5. The cooperative assembly of MDA5 into helical filaments on dsRNA nucleates the assembly of a...
AGS ATPase Aicardi-Goutières syndrome DExD/H-box RNA helicase RIG-I-like receptor RLR SF2 helicases SMS Singleton-Merten syndrome cryo-EM Cryoelectron Microscopy helical reconstruction innate immune pattern recognition nucleic acid sensing superfamily 2 helicases Adenosine Triphosphate Cryoelectron Microscopy HEK293 Cells Humans Hydrolysis Hydrophobic and Hydrophilic Interactions Interferon-Induced Helicase IFIH1 Interferon-beta Molecular Docking Simulation Mutation Nucleic Acid Conformation Protein Conformation RNA Double-Stranded Signal Transduction Structure-Activity Relationship
Surface chromium on Terracotta Army bronze weapons is neither an ancient anti-rust treatment nor the reason for their good preservation.
Marcos Martinón-Torres, Xiuzhen Li, Yin Xia, Agnese Benzonelli, Andrew Bevan, Shengtao Ma, Jianhua Huang, Liang Wang, Desheng Lan, Jiangwei Liu, Siran Liu, Zhen Zhao, Kun Zhao, Thilo Rehren
May 10, 2019
For forty years, there has been a widely held belief that over 2,000 years ago the Chinese Qin developed an advanced chromate conversion coating technology (CCC) to prevent metal corrosion. This belief was based on the detection...
Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition.
Epithelial-mesenchymal transition (EMT) is a dedifferentiation program in which polarized, differentiated epithelial cells lose their cell-cell adhesions and transform into matrix-producing mesenchymal cells. EMT of retinal...
Mitochondria metabolism proliferative vitreoretinopathy Metabolomics age-related macular degeneration Glycolysis OXPHOS epithelial-mesenchymal transition (EMT) retinal pigment epithelium (RPE) tumor necrosis factor-alpha (TNFα) transforming growth factor-beta (TGFβ)
Published by: Metabolites
Water Supply-Demand Management under Climate Change
This study aimed to investigate optimal multiple reservoir operations and water demand management considering climate change impact. In this study, conditional density estimation network creation and evaluation (CaDENCE) method...
Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition.
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