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Results: 27
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice
Most treatments that prevent autoimmune diabetes in nonobese diabetic (NOD) mice require intervention at early pathogenic stages, when insulitis is first developing. We tested whether dendritic cell (DC)-expanded, islet...
Published by: Rockefeller University
Analysis on the Legal System of International Technology Trade Management Based on Data Mining Analysis
With the rapid development of computer and information technology, people can obtain and store data in a faster and cheaper way, which makes the amount of data and information grow exponentially. Based on data mining technology...
Published by: IGI Global Scientific Publishing
Reading Both Single and Multiple Digital Video Clocks Using Context-Aware Pixel Periodicity and Deep Learning
This article presents an algorithm for reading both single and multiple digital video clocks by using a context-aware pixel periodicity method and a deep learning technique. Reading digital video clocks in real time is a very...
Published by: IGI Global Scientific Publishing
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
Juraj Konč, Libby Brown, Daniel R. Whiten, Yukun Zuo, Peter Ravn, David Klenerman, Gonçalo J. L. Bernardes
Nov 03, 2021
Abstract: Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site‐specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for...
RESEARCH ARTICLE RESEARCH ARTICLES Antibodies bioconjugation Imaging Mass Spectrometry Nucleic Acids
Published by: Angewandte Chemie International Edition
A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides
Juraj Konč, Libby Brown, Daniel R Whiten, Yukun Zuo, Peter Ravn, David Klenerman, Gonçalo JL Bernardes
Nov 24, 2021
Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site-specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for biological...
The Effects of the Transformational Leadership Model on Teachers' Organizational Justice and Job Satisfaction in Private Universities in Shandong Province
This study analyze how transformational leadership affects job satisfaction and explore the relationship between transformational leadership and teachers' satisfaction through organizational justice and psychological capital in...
Published by: IGI Global Scientific Publishing
Recent Progress in Mixed A‐Site Cation Halide Perovskite Thin‐Films and Nanocrystals for Solar Cells and Light‐Emitting Diodes
Mahdi Malekshahi Byranvand, Clara Otero‐Martínez, Junzhi Ye, Weiwei Zuo, Liberato Manna, Michael Saliba, Robert LZ Hoye, Lakshminarayana Polavarapu
Jun 29, 2022
A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides.
Juraj Konč, Libby Brown, Daniel R Whiten, Yukun Zuo, Peter Ravn, David Klenerman, Gonçalo JL Bernardes
Sep 28, 2021
Many bioconjugation strategies for DNA oligonucleotides and antibodies suffer limitations, such as site-specificity, stoichiometry and hydrolytic instability of the conjugates, which makes them unsuitable for biological...
Fuzzy SVM With Mahalanobis Distance for Situational Awareness-Based Recognition of Public Health Emergencies
In public health emergencies, situational awareness is crucial for swift responses by governments and rescue organizations. In this manuscript, a novel framework is proposed to identify and classify event-specific information...
Published by: IGI Global Scientific Publishing
Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation.
Suzan Fares, Katja Spiess, Emma TB Olesen, Jianmin Zuo, Sarah Jackson, Thomas N Kledal, Mark R Wills, Mette M Rosenkilde
Feb 07, 2019
The Epstein-Barr virus (EBV) BILF1 gene encodes a constitutively active G protein-coupled receptor (GPCR) that downregulates major histocompatibility complex (MHC) class I and induces signaling-dependent tumorigenesis. Different...
Performance and Cost Assessment of Machine Learning Interatomic Potentials.
Yunxing Zuo, Chi Chen, Xiangguo Li, Zhi Deng, Yiming Chen, Jörg Behler, Gábor Csányi, Alexander V Shapeev, Aidan P Thompson, Mitchell A Wood, Shyue Ping Ong
Dec 22, 2020
Machine learning of the quantitative relationship between local environment descriptors and the potential energy surface of a system of atoms has emerged as a new frontier in the development of interatomic potentials (IAPs)....
Associations of Alzheimer's disease risk variants with gene expression, amyloidosis, tauopathy, and neurodegeneration.
Meng-Shan Tan, Yu-Xiang Yang, Wei Xu, Hui-Fu Wang, Lin Tan, Chuan-Tao Zuo, Qiang Dong, Lan Tan, John Suckling, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative
Mar 12, 2021
BACKGROUND: Genome-wide association studies have identified more than 30 Alzheimer's disease (AD) risk genes, although the detailed mechanism through which all these genes are associated with AD pathogenesis remains unknown. We...
Unconventional quantum vortex matter state hosts quantum oscillations in the underdoped high-temperature cuprate superconductors.
Yu-Te Hsu, Máté Hartstein, Alexander J Davies, Alexander J Hickey, Mun K Chan, Juan Porras, Toshinao Loew, Sofia V Taylor, Hsu Liu, Alexander G Eaton, Matthieu Le Tacon, Huakun Zuo, Jinhua Wang, Zengwei Zhu, Gilbert G Lonzarich, Bernhard Keimer, Neil Harrison, Suchitra E Sebastian
Feb 03, 2021
Longitudinal trajectories of Alzheimer's ATN biomarkers in elderly persons without dementia.
Meng-Shan Tan, Xi Ji, Jie-Qiong Li, Wei Xu, Hui-Fu Wang, Chen-Chen Tan, Qiang Dong, Chuan-Tao Zuo, Lan Tan, John Suckling, Jin-Tai Yu, Alzheimer’s Disease Neuroimaging Initiative
May 22, 2020
BACKGROUND: Models of Alzheimer's disease (AD) pathophysiology posit that amyloidosis [A] precedes and accelerates tau pathology [T] that leads to neurodegeneration [N]. Besides this A-T-N sequence, other biomarker sequences are...
Nanoscopic Characterisation of Individual Endogenous Protein Aggregates in Human Neuronal Cells.
Daniel R Whiten, Yukun Zuo, Laura Calo, Minee-Liane Choi, Suman De, Patrick Flagmeier, David C Wirthensohn, Franziska Kundel, Rohan T Ranasinghe, Santiago E Sanchez, Dilan Athauda, Steven F Lee, Christopher M Dobson, Sonia Gandhi, Maria-Grazia Spillantini, David Klenerman, Mathew H Horrocks
Sep 05, 2018
Community voices
Rocío Deanna, Bethann Garramon Merkle, Kwok Pan Chun, Deborah Navarro-Rosenblatt, Ivan Baxter, Nora Oleas, Alejandro Bortolus, Patricia Geesink, Luisa Diele-Viegas, Valeria Aschero, María José de Leone, Sonia Oliferuk, Rui Zuo, Andrea Cosacov, Mariana Grossi, Sandra Knapp, Alicia Lopez-Mendez, Elina Welchen, Pamela Ribone, Gabriela Auge
Apr 26, 2022
Published by: Nature Communications
Satellite Observations for Detecting and Forecasting Sea-Ice Conditions
The detection, monitoring, and forecasting of sea-ice conditions, including their extremes, is very important for ship navigation and offshore activities, and for monitoring of sea-ice processes and trends. We summarize...
Marko Mäkynen, Jari Haapala, Giuseppe Aulicino, Beena Balan-Sarojini, Magdalena Balmaseda, Alexandru Gegiuc, Fanny Girard-Ardhuin, Stefan Hendricks, Georg Heygster, Larysa Istomina, Lars Kaleschke, Juha Karvonen, Thomas Krumpen, Mikko Lensu, Michael Mayer, Flavio Parmiggiani, Robert Ricker, Eero Rinne, Amelie Schmitt, Markku Similä, Steffen Tietsche, Rasmus Tonboe, Peter Wadhams, Mai Winstrup, Hao Zuo
Apr 11, 2020
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.
Huaixing Li, Wei Gan, Ling Lu, Xiao Dong, Xueyao Han, Cheng Hu, Zhen Yang, Liang Sun, Wei Bao, Pengtao Li, Meian He, Liangdan Sun, Yiqin Wang, Jingwen Zhu, Qianqian Ning, Yong Tang, Rong Zhang, Jie Wen, Di Wang, Xilin Zhu, Kunquan Guo, Xianbo Zuo, Xiaohui Guo, Handong Yang, Xianghai Zhou, DIAGRAM Consortium, AGEN-T2D Consortium, Xuejun Zhang, Lu Qi, Ruth JF Loos, Frank B Hu, Tangchun Wu, Ying Liu, Liegang Liu, Ze Yang, Renming Hu, Weiping Jia, Linong Ji, Yixue Li, Xu Lin
Feb 22, 2018
Substantial progress has been made in identification of type 2 diabetes (T2D) risk loci in the past few years, but our understanding of the genetic basis of T2D in ethnically diverse populations remains limited. We performed a...
Adiposity Blood Glucose China DNA-Binding Proteins Diabetes mellitus Type 2 G-Protein-Coupled Receptor Kinase 5 Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Guanine Nucleotide Exchange Factors Humans Linkage Disequilibrium Polymorphism Single Nucleotide Quantitative Trait Loci
An open-access database and analysis tool for perovskite solar cells based on the FAIR data principles
Abstract Large datasets are now ubiquitous as technology enables higher-throughput experiments, but rarely can a research field truly benefit from the research data generated due to inconsistent...
TJ Jacobsson, A Hultqvist, A García-Fernández, A Anand, A Al-Ashouri, A Hagfeldt, A Crovetto, A Abate, AG Ricciardulli, A Vijayan, A Kulkarni, AY Anderson, BP Darwich, B Yang, BL Coles, CAR Perini, C Rehermann, D Ramirez, D Fairen-Jimenez, D Di Girolamo, D Jia, E Avila, EJ Juarez-Perez, F Baumann, F Mathies, GSA González, G Boschloo, G Nasti, G Paramasivam, G Martínez-Denegri, H Näsström, H Michaels, H Köbler, H Wu, I Benesperi, MI Dar, I Bayrak Pehlivan, IE Gould, JN Vagott, J Dagar, J Kettle, J Yang, J Li, JA Smith, J Pascual, JJ Jerónimo-Rendón, JF Montoya, JP Correa-Baena, J Qiu, J Wang, K Sveinbjörnsson, K Hirselandt, K Dey, K Frohna, L Mathies, LA Castriotta, MH Aldamasy, M Vasquez-Montoya, MA Ruiz-Preciado, MA Flatken, MV Khenkin, M Grischek, M Kedia, M Saliba, M Anaya, M Veldhoen, N Arora, O Shargaieva, O Maus, OS Game, O Yudilevich, P Fassl, Q Zhou, R Betancur, R Munir, R Patidar, SD Stranks, S Alam, S Kar, T Unold, T Abzieher, T Edvinsson, TW David, UW Paetzold, W Zia, W Fu, W Zuo, VRF Schröder, W Tress, X Zhang, YH Chiang, Z Iqbal, Z Xie, E Unger
Jan 29, 2022
Brain charts for the human lifespan
RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, R Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, DP Linares, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, BTT Yeo, HJ Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, AF Alexander-Bloch, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, ASRB, CALM team, Cam-CAN, 3R-BRAIN CCNP, COBRE, ENIGMA Developmental Brain Age Working Group, FinnBrain, Harvard Aging Brain Study, KNE96 IMAGEN, NSPN, OASIS-3, OpenPain Project, POND, VETSA, Bullmore, E.T The PREVENT-AD Research Group
Sep 24, 2022
Over the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in...
AIBL Alzheimer’s Disease Neuroimaging Initiative Alzheimer’s Disease Repository Without Borders Investigators ASRB CALM Team Cam-CAN CCNP 3R-BRAIN COBRE ENIGMA Developmental Brain Age working group FinnBrain Harvard Aging Brain Study IMAGEN KNE96 NSPN OASIS-3 OpenPain Project POND The PREVENT-AD Research Group VETSA Bullmore E.T
Brain charts for the human lifespan.
RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, J Bae, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, M Costantino, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, R Delorme, S Desrivieres, GA Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, E Feczko, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, IM Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, RN Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, RS Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, KW Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, SR Mathias, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, D Paz-Linares, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, A Rodrigue, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, N Traut, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, B Yeo, H Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, CALM team, Cam-CAN, CCNP, COBRE, cVEDA, ENIGMA Developmental Brain Age Working Group, Developing Human Connectome Project, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, Mayo Clinic Study of Aging, NSPN, POND, PREVENT-AD Research Group, VETSA, ET Bullmore, AF Alexander-Bloch
Apr 21, 2022
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging...
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