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Polycystin-1 inhibits eIF2α phosphorylation and cell apoptosis through a PKR-eIF2α pathway.
Yan Tang, Zuocheng Wang, JungWoo Yang, Wang Zheng, Di Chen, Guanqing Wu, Richard Sandford, Jingfeng Tang, Xing-Zhen Chen
Jan 17, 2018
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 or PKD2 which encodes polycystin-1 (PC1) and polycystin-2, respectively. PC1 was previously shown to slow cell proliferation and inhibit...
Chemical Biology, Biochemical and Structural Studies of MDN1, an AAA Protein Required for Ribosome Biogenesis
Zhen Chen
Jan 01, 0001
Cellular proteins are synthesized by ribosomes, which are ~3 MDa macromolecular complexes comprised of four ribosomal RNAs and ~80 ribosomal proteins in yeast. The biogenesis of such complicated ribonucleoprotein complexes is a...
Published by: Rockefeller University
Ultrafast Field-Emission Electron Sources Based on Nanomaterials
The search for electron sources with simultaneous optimal spatial and temporal resolution has become an area of intense activity for a wide variety of applications in the emerging fields of lightwave electronics and...
The search for electron sources with simultaneous optimal spatial and temporal resolution has become an area of intense activity for a wide variety of applications in the emerging fields of lightwave electronics and...
Ultrafast Field-Emission Electron Sources Based on Nanomaterials
The search for electron sources with simultaneous optimal spatial and temporal resolution has become an area of intense activity for a wide variety of applications in the emerging fields of lightwave electronics and...
The search for electron sources with simultaneous optimal spatial and temporal resolution has become an area of intense activity for a wide variety of applications in the emerging fields of lightwave electronics and...
Single crystal of a one-dimensional metallo-covalent organic framework.
Hai-Sen Xu, Yi Luo, Xing Li, Pei Zhen See, Zhongxin Chen, Tianqiong Ma, Lin Liang, Kai Leng, Ibrahim Abdelwahab, Lin Wang, Runlai Li, Xiangyan Shi, Yi Zhou, Xiu Fang Lu, Xiaoxu Zhao, Cuibo Liu, Junliang Sun, Kian Ping Loh
May 18, 2020
Published by: Nature Communications
Vortex coupling in trailing vortex-wing interactions
The interaction of trailing vortices of an upstream wing with rigid and flexible downstream wings has been investigated experimentally in a wind tunnel, using particle image velocimetry, hot-wire, force and deformation...
The impact of the COVID-19 pandemic on the mental health of young people
Ming-Bo Liu, Géraldine Dufour, Zhuo-Er Sun, Julieta Galante, Chen-Qi Xing, Jing-Ye Zhan, Li-Li Wu
Mar 09, 2021
PURPOSE: As COVID-19 spreads globally and affects people's health, there are concerns that the pandemic and control policies may have psychological effects on young people (age from 17 to 35 years). This psychological impact...
Vortex coupling in trailing vortex-wing interactions
The interaction of trailing vortices of an upstream wing with rigid and flexible downstream wings has been investigated experimentally in a wind tunnel, using particle image velocimetry, hot-wire, force and deformation...
Behavior of Corexit dispersants in the Gulf of Mexico after the Deepwater Horizon oil spill
Offshore Oil spills are of tremendous concern due to its enormous harm to economic and ecological systems. Corexit dispersants are used as an important combating agent for oil spills as they can dilute oil downward to water...
Improving motivation through real-time fMRI-based self-regulation of the nucleus accumbens.
Zhi Li, Chen-Yuan Zhang, Jia Huang, Yi Wang, Chao Yan, Ke Li, Ya-Wei Zeng, Zhen Jin, Eric FC Cheung, Li Su, Raymond CK Chan
Nov 07, 2017
OBJECTIVE: Impaired nucleus accumbens (NAcc) activation is associated with amotivation and anhedonia, which are resistant to treatment with antipsychotics and antidepressants in schizophrenia. In this study, healthy participants...
Behavior of Corexit dispersants in the Gulf of Mexico after the Deepwater Horizon oil spill
Offshore Oil spills are of tremendous concern due to its enormous harm to economic and ecological systems. Corexit dispersants are used as an important combating agent for oil spills as they can dilute oil downward to water...
A microfluidic serial dilutor (MSD)
Huanhuan Shi, Zhihao Xie, Yu Cao, Yali Zhao, Congxuan Zhang, Zhen Chen, Nuno M. Reis, Zhengchun Liu
Dec 14, 2022
Dilution of a sample over several orders of magnitude in concentration is a routine procedure in many analytical, bioanalytical, diagnostics, and formulation laboratories. Microfluidics offer the opportunity to automate the...
Ultralow-voltage operation of light-emitting diodes.
Yaxiao Lian, Dongchen Lan, Shiyu Xing, Bingbing Guo, Zhixiang Ren, Runchen Lai, Chen Zou, Baodan Zhao, Richard H Friend, Dawei Di
Aug 06, 2022
For a light-emitting diode (LED) to generate light, the minimum voltage required is widely considered to be the emitter's bandgap divided by the elementary charge. Here we show for many classes of LEDs, including those based on...
Secondary Metabolites of Osmanthus fragrans
Chen-Chen Fu, Fa-Ying Xu, Yu-Chen Qian, Hoi-Lun Koo, Yi-Fan Duan, Geng-Min Weng, Tai-Ping Fan, Mo-Xian Chen, Fu-Yuan Zhu
Aug 01, 2022
Osmanthus fragrans (scientific name: Osmanthus fragrans (Thunb.) Lour.) is a species of the Osmanthus genus in the family Oleaceae, and it has a long history of cultivation in China. O. fragrans is edible and is well known for...
Geometrical Evaluation on the Viscous Effect of Point-Absorber Wave-Energy Converters
The fluid viscosity is known to have a significant effect on the hydrodynamic characteristics which are linked to the power conversion ability of the wave energy converter (WEC). To overcome the disadvantages of case-by-case...
Determination of safe operation zone for an intermediate-temperature solid oxide fuel cell and gas turbine hybrid system
This paper proposes a novel approach to determine the safe zone for an intermediate-temperature solid oxide fuel cell and gas turbine hybrid system. The approach first ensures the compressor safety and then determines the...
Geometrical Evaluation on the Viscous Effect of Point-Absorber Wave-Energy Converters
The fluid viscosity is known to have a significant effect on the hydrodynamic characteristics which are linked to the power conversion ability of the wave energy converter (WEC). To overcome the disadvantages of case-by-case...
CAMKs support development of acute myeloid leukemia.
Xunlei Kang, Changhao Cui, Chen Wang, Guojin Wu, Heyu Chen, Zhigang Lu, Xiaoli Chen, Li Wang, Jie Huang, Huimin Geng, Meng Zhao, Zhengshan Chen, Markus Müschen, Huan-You Wang, Cheng Cheng Zhang
Oct 03, 2018
BACKGROUND: We recently identified the human leukocyte immunoglobulin-like receptor B2 (LILRB2) and its mouse ortholog-paired Ig-like receptor (PirB) as receptors for several angiopoietin-like proteins (Angptls). We also...
acute myeloid leukemia CAMK CREB LILRB2 Leukemic stem cell PirB Animals Calcium-Calmodulin-Dependent Protein Kinases Carcinogenesis Cell Line Tumor Disease Models Animal Disease Progression Humans Leukemia Myeloid Acute Mice Inbred C57BL Neoplastic Stem Cells Receptors Immunologic Signal Transduction
A microfluidic serial dilutor (MSD)
Huanhuan Shi, Zhihao Xie, Yu Cao, Yali Zhao, Congxuan Zhang, Zhen Chen, Nuno M. Reis, Zhengchun Liu
Dec 14, 2022
Dilution of a sample over several orders of magnitude in concentration is a routine procedure in many analytical, bioanalytical, diagnostics, and formulation laboratories. Microfluidics offer the opportunity to automate the...
Spatio-temporal evolution of human neural activity during visually cued hand movements
Guangye Li, Shize Jiang, Jianjun Meng, Zehan Wu, Haiteng Jiang, Zhen Fan, Jie Hu, Xinjun Sheng, Dingguo Zhang, Gerwin Schalk, Liang Chen, Xiangyang Zhu
Sep 01, 2023
Making hand movements in response to visual cues is common in daily life. It has been well known that this process activates multiple areas in the brain, but how these neural activations progress across space and time remains...
Mobile Applications in China's Smart Cities
Aligned with the global trend of smartness, China has invested heavily in over 700 smart city projects across over 500 cities. Hundreds of smart city apps, initiated by local authorities, have so emerged in the daily lives of...
Published by: IGI Global Scientific Publishing
Revealing the Drag Instability in One-fluid Nonideal Magnetohydrodynamic Simulations of a 1D Isothermal C-shock
Abstract
C-type shocks are believed to be ubiquitous in turbulent molecular clouds thanks to ambipolar diffusion. We investigate whether the drag instability in 1D isothermal...
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