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How to measure technology intelligence?
Technology intelligence (TI) is an activity that supports decision-making at many levels. However, practitioners often find that evaluating the quality of TI activities can be very challenging. Whilst several papers in current...
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1)
Elizabeth M Swisher, Kevin K Lin, Amit M Oza, Clare L Scott, Heidi Giordano, James Sun, Gottfried E Konecny, Robert L Coleman, Anna V Tinker, David M O'Malley, Rebecca S Kristeleit, Ling Ma, Katherine M Bell-McGuinn, James D Brenton, Janiel M Cragun, Ana Oaknin, Isabelle Ray-Coquard, Maria I Harrell, Elaina Mann, Scott H Kaufmann, Anne Floquet, Alexandra Leary, Thomas C Harding, Sandra Goble, Lara Maloney, Jeff Isaacson, Andrew R Allen, Lindsey Rolfe, Roman Yelensky, Mitch Raponi, Iain A McNeish
Sep 21, 2018
BACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors have activity in ovarian carcinomas with homologous recombination deficiency. Along with BRCA1 and BRCA2 (BRCA) mutations genomic loss of heterozygosity (LOH) might also...
Aged Antineoplastic Agents BRCA1 Protein BRCA2 Protein Carcinoma Ovarian Epithelial Drug Resistance Neoplasm Fallopian Tube Neoplasms Female Follow-Up Studies Germ-Line Mutation Humans Indoles International Agencies Middle Aged Neoplasm Recurrence Local Neoplasm Staging Neoplasms Glandular and Epithelial Ovarian Neoplasms Peritoneal Neoplasms Platinum Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases Prognosis Prospective Studies Salvage therapy Survival Rate
CD3- leukocytes present in the human uterus during early placentation
Monitoring Real-time Temperature Dynamics of a Short RNA Hairpin Using Förster Resonance Energy Transfer and Circular Dichroism.
RNA secondary structures are highly dynamic and subject to prompt changes in response to the environment. Temperature in particular has a strong impact on RNA structural conformation, and temperature-sensitive RNA hairpin...
Effect of 5'UTR introns on gene expression in Arabidopsis thaliana.
BACKGROUND: The majority of introns in gene transcripts are found within the coding sequences (CDSs). A small but significant fraction of introns are also found to reside within the untranslated regions (5'UTRs and 3'UTRs) of...
p53 mutation in normal esophagus promotes multiple stages of carcinogenesis but is constrained by clonal competition.
Kasumi Murai, Stefan Dentro, Swee Hoe Ong, Roshan Sood, David Fernandez-Antoran, Albert Herms, Vasiliki Kostiou, Irina Abnizova, Benjamin A Hall, Moritz Gerstung, Philip H Jones
Nov 20, 2022
Aging normal human oesophagus accumulates TP53 mutant clones. These are the origin of most oesophageal squamous carcinomas, in which biallelic TP53 disruption is almost universal. However, how p53 mutant clones expand and...
A systematic review of methods to measure family co-participation in physical activity.
The family environment is key in influencing children's health behaviours. Encouraging family co-participation in physical activity may therefore be an effective approach to increasing children's physical activity levels. Yet...
Hydrophobic photonic crystal fibers
We propose and demonstrate hydrophobic photonic crystal fibers (PCFs). A chemical surface treatment for making PCFs hydrophobic is introduced. This repels water from the holes of PCFs, so that their optical properties remain...
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Abstract: Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to...
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Alzheimer's disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer's disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial...
Published by: Cell Death & Disease
Objectively measured sedentary time, physical activity and kidney function in people with recently diagnosed Type 2 diabetes
Adult Aged Albuminuria Cohort Studies Creatinine Diabetes mellitus Type 2 Disease Progression Energy Metabolism Exercise Female Follow-Up Studies Glomerular Filtration Rate Humans Hypoglycemic Agents Linear Models Logistic Models Male Middle Aged Multivariate Analysis Prospective Studies Renal Insufficiency Chronic Sedentary Behavior Time Factors
Leisure reading in multilingual Singapore
What are bilingual children reading? Do children who enjoy reading books in one language also enjoy reading books in the other language? Drawing on survey data from 1,312 children (aged 9–11) in two government primary...
What are bilingual children reading? Do children who enjoy reading books in one language also enjoy reading books in the other language? Drawing on survey data from 1,312 children (aged 9–11) in two government primary...
Perioperative management of open fractures in the lower limb.
An open fracture is a fracture which communicates with the external environment through a wound in the skin. Severe open fractures are managed by both orthopaedic and plastic surgeons to address injuries in both the bone and...
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Alzheimer's disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer's disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial...
Alzheimer Disease Amyloid beta-Peptides Animals Animals Genetically Modified Behavior Animal Disease Models Animal Drosophila Proteins Drosophila melanogaster Humans Metabolome Metabolomics Mitochondria Motor Activity Mutation NAD Nerve Degeneration Neurons Niacinamide Poly (ADP-Ribose) Polymerase-1 Polymorphism Single Nucleotide
Combined Transcriptomic and Proteomic Analysis of Perk Toxicity Pathways
Rebeka Popovic, Ivana Celardo, Yizhou Yu, Ana C. Costa, Samantha H. Y. Loh, L. Miguel Martins
Apr 29, 2021
In Drosophila, endoplasmic reticulum (ER) stress activates the protein kinase R-like endoplasmic reticulum kinase (dPerk). dPerk can also be activated by defective mitochondria in fly models of Parkinson’s disease caused by...
Homologous recombination DNA repair defects in PALB2- associated breast cancers
Anqi Li, Felipe C. Geyer, Pedro Blecua, Ju Youn Lee, Pier Selenica, David N. Brown, Fresia Pareja, Simon S. K. Lee, Rahul Kumar, Barbara Rivera, Rui Bi, Salvatore Piscuoglio, Hannah Y. Wen, John R. Lozada, Rodrigo Gularte-Mérida, Luca Cavallone, Zoulikha Rezoug, Tu Nguyen-Dumont, Paolo Peterlongo, Carlo Tondini, Thorkild Terkelsen, Karina Rønlund, Susanne E. Boonen, Arto Mannerma, Robert Winqvist, Marketa Janatova, Pathmanathan Rajadurai, Bing Xia, Larry Norton, Mark E. Robson, Pei-Sze Ng, Lai-Meng Looi, Melissa C. Southey, Britta Weigelt, Teo Soo-Hwang, Marc Tischkowitz, William D. Foulkes, Jorge S. Reis-Filho, Morteza Aghmesheh, David Amor, Leslie Andrews, Yoland Antill, Rosemary Balleine, Jonathan Beesley, Anneke Blackburn, Michael Bogwitz, Melissa Brown, Matthew Burgess, Jo Burke, Phyllis Butow, Liz Caldon, Ian Campbell, Alice Christian, Christine Clarke, Paul Cohen, Ashley Crook, James Cui, Margaret Cummings, Sarah-Jane Dawson, Anna de Fazio, Martin Delatycki, Alex Dobrovic, Tracy Dudding, Pascal Duijf, Edward Edkins, Stacey Edwards, Gelareh Farshid, Andrew Fellows, Michael Field, James Flanagan, Peter Fong, John Forbes, Laura Forrest, Stephen Fox, Juliet French, Michael Friedlander, David Gallego Ortega, Michael Gattas, Graham Giles, Grantley Gill, Margaret Gleeson, Sian Greening, Eric Haan, Marion Harris, Nick Hayward, Ian Hickie, John Hopper, Clare Hunt, Paul James, Mark Jenkins, Rick Kefford, Maira Kentwell, Judy Kirk, James Kollias, Sunil Lakhani, Geoff Lindeman, Lara Lipton, Lizz Lobb, Sheau Lok, Finlay Macrea, Graham Mann, Deb Marsh, Sue-Anne McLachlan, Bettina Meiser, Roger Milne, Sophie Nightingale, Shona O’Connell, Nick Pachter, Briony Patterson, Kelly Phillips, Mona Saleh, Elizabeth Salisbury, Christobel Saunders, Jodi Saunus, Clare Scott, Rodney Scott, Adrienne Sexton, Andrew Shelling, Peter Simpson, Allan Spigelman, Mandy Spurdle, Jennifer Stone, Jessica Taylor, Heather Thorne, Alison Trainer, Georgia Trench, Kathy Tucker, Jane Visvader, Logan Walker, Mathew Wallis, Rachael Williams, Ingrid Winship, Kathy Wu, Mary Anne Young
Aug 07, 2020
Abstract: Mono-allelic germline pathogenic variants in the Partner And Localizer of BRCA2 (PALB2) gene predispose to a high-risk of breast cancer development, consistent with the role of PALB2 in homologous recombination (HR)...
Parp mutations protect from mitochondrial toxicity in Alzheimer’s disease
Abstract: Alzheimer’s disease is the most common age-related neurodegenerative disorder. Familial forms of Alzheimer’s disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to...
Perioperative management of distal radius fractures.
Fractures of the distal radius are the most common upper limb fracture and account for over a sixth of all fractures seen in emergency departments. Although most of these fractures are managed non-operatively, a significant...
Leisure reading in multilingual Singapore
What are bilingual children reading? Do children who enjoy reading books in one language also enjoy reading books in the other language? Drawing on survey data from 1,312 children (aged 9–11) in two government primary...
What are bilingual children reading? Do children who enjoy reading books in one language also enjoy reading books in the other language? Drawing on survey data from 1,312 children (aged 9–11) in two government primary...
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