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GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health.
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R Day, Hana Lango Allen, Nicola D Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J Wareham, Claudia Langenberg, Ken K Ong, John RB Perry
Jun 28, 2021
Adult Aged Carrier Proteins Case-Control Studies Chromosomes Human Y DNA Mutational Analysis Diabetes mellitus Type 2 Female Genetic Predisposition to Disease Genome-Wide Association Study Humans Insulin Leukocytes Loss of Function Mutation Male Middle Aged Mosaicism Receptor IGF Type 1 Signal Transduction Exome Sequencing
GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R. Day, Hana Lango Allen, Nicola D. Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J. Wareham, Claudia Langenberg, Ken K. Ong, John R. B. Perry
Jul 07, 2021
Abstract: Mosaic loss of chromosome Y (LOY) in leukocytes is the most common form of clonal mosaicism, caused by dysregulation in cell-cycle and DNA damage response pathways. Previous genetic studies have focussed on identifying...
GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health.
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R Day, Hana Lango Allen, Nicola D Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J Wareham, Claudia Langenberg, Ken K Ong, John R B Perry
Aug 11, 2021
Leukocytes Chromosomes Human Y Humans Diabetes mellitus Type 2 Genetic Predisposition to Disease Insulin Receptor IGF Type 1 Carrier Proteins Case-Control Studies DNA Mutational Analysis Signal Transduction Mosaicism Adult Aged Middle Aged Female Male Genome-Wide Association Study Whole exome sequencing Loss of Function Mutation
Published by: Nature Communications
Support of modified Archimedes' law theory in granular media.
We study the resistance force of cylindrical objects penetrating quasi-statically into granular media experimentally and numerically. Simulations are validated against experiments. In contrast to previous studies, we find in...
Xenopus DPPA2 is a Direct Inhibitor of Microtubule Polymerization Required for Nuclear Assembly
John Zhao Xue
Jan 01, 0001
The eukaryotic nucleus mediates the genomic functions of information storage and gene expression, but must be completely rebuilt after every open mitosis as well as during fertilization. Nuclear abnormalities are observed in...
Published by: Rockefeller University
Variable Selection for a Categorical Varying-Coefficient Model with Identifications for Determinants of Body Mass Index
Obesity has become one of the major public health issues during the last three decades. A considerable number of determinants have been proposed for body mass index (BMI) by a large range of studies from multiple disciplines. In...
Variable Selection for a Categorical Varying-Coefficient Model with Identifications for Determinants of Body Mass Index
Obesity has become one of the major public health issues during the last three decades. A considerable number of determinants have been proposed for body mass index (BMI) by a large range of studies from multiple disciplines. In...
Human and mouse leukocytes
Simón Méndez-Ferrer
Mar 19, 2018
In this issue of Blood, Zhao et al use a humanized mouse model to investigate the mechanisms driving daily oscillations in circulating human and murine leukocytes.1 In the same mice, they find human and murine circulating...
Towards prediction of ordered phases in rechargeable battery chemistry via group–subgroup transformation
Yunbing Ran, Zheyi Zou, Bo Liu, Da Wang, Bowei Pu, Penghui Mi, Wei Shi, Yajie Li, Bing He, Ziheng Lu, Xia Lu, Baihai Li, Siqi Shi
Jan 28, 2022
Abstract: The electrochemical thermodynamic and kinetic characteristics of rechargeable batteries are critically influenced by the ordering of mobile ions in electrodes or solid electrolytes. However, because of the experimental...
Does PGA external stenting reduce compliance mismatch in venous grafts?
Zhong-zhao Teng, Guang-yu Ji, Hong-jun Chu, Zhi-Yong Li, Liang-jian Zou, Zhi-yun Xu, Sheng-dong Huang
Jun 16, 2011
Metabolically Specific In Situ Fluorescent Visualization of Bacterial Infection on Wound Tissues
Chen Jian Zhong, Xi Le Hu, Xiao Lan Yang, Hui Qi Gan, Kai Cheng Yan, Fu Ting Shu, Pei Wei, Teng Gong, Peng Fei Luo, Tony D. James, Zhao Hong Chen, Yong Jun Zheng, Xiao Peng He, Zhao Fan Xia
Sep 07, 2022
The ability to effectively detect bacterial infection in human tissues is important for the timely treatment of the infection. However, traditional techniques fail to visualize bacterial species adhered to host cells in situ...
Proline-Based Boronic Acid Receptors for Chiral Recognition of Glucose
Lin-E Guo, Yuan Hong, Shu-Ying Zhang, Miao Zhang, Xiao-Sheng Yan, Jin-Lian Cao, Zhao Li, Tony D James, Yun-Bao Jiang
Dec 21, 2018
Chiral recognition remains a major challenge in the area of molecular receptor design. With this research, we set out to explore the use of proline-based receptors for chiral recognition. Importantly, the proline structure...
Impact of Correlated Noise on the Mass Precision of Earth-analog Planets in Radial Velocity Surveys
Jacob K. Luhn, Eric B. Ford, Zhao Guo, Christian Gilbertson, Patrick Newman, Peter Plavchan, Jennifer A. Burt, Johanna Teske, Arvind F. Gupta
Feb 10, 2023
Characterizing the masses and orbits of near-Earth-mass planets is crucial for interpreting observations from future direct imaging missions (e.g., HabEx, LUVOIR). Therefore, the Exoplanet Science Strategy report recommended...
Published by: The American Astronomical Society
Metabolically Specific In Situ Fluorescent Visualization of Bacterial Infection on Wound Tissues
Chen Jian Zhong, Xi Le Hu, Xiao Lan Yang, Hui Qi Gan, Kai Cheng Yan, Fu Ting Shu, Pei Wei, Teng Gong, Peng Fei Luo, Tony D. James, Zhao Hong Chen, Yong Jun Zheng, Xiao Peng He, Zhao Fan Xia
Sep 07, 2022
The ability to effectively detect bacterial infection in human tissues is important for the timely treatment of the infection. However, traditional techniques fail to visualize bacterial species adhered to host cells in situ...
In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution.
Muyuan Chen, Xiaodong Shi, Zhili Yu, Guizhen Fan, Irina I Serysheva, Matthew L Baker, Ben F Luisi, Steven J Ludtke, Zhao Wang
Sep 16, 2021
The tripartite AcrAB-TolC assembly, which spans both the inner and outer membranes in Gram-negative bacteria, is an efflux pump that contributes to multidrug resistance. Here, we present the in situ structure of full-length...
AcrAB-TolC cryo-ET in situ multidrug efflux pump subnanometer resolution Allosteric Regulation Bacterial Outer Membrane Proteins Carrier Proteins Cryoelectron Microscopy Electron Microscope Tomography Escherichia coli Escherichia coli Proteins Ligands Lipoproteins Membrane Transport Proteins Models Molecular Multidrug Resistance-Associated Proteins Protein Conformation
Proline-Based Boronic Acid Receptors for Chiral Recognition of Glucose
Lin-E Guo, Yuan Hong, Shu-Ying Zhang, Miao Zhang, Xiao-Sheng Yan, Jin-Lian Cao, Zhao Li, Tony D James, Yun-Bao Jiang
Dec 21, 2018
Chiral recognition remains a major challenge in the area of molecular receptor design. With this research, we set out to explore the use of proline-based receptors for chiral recognition. Importantly, the proline structure...
An Organic-Inorganic Hybrid Exhibiting Electrical Conduction and Single-Ion-Magnetism.
Yongbing Shen, Goulven Cosquer, Hiroshi Ito, David Chukwuma Izuogu, Alex JW Thom, Toshiaki Ina, Tomoya Uruga, Takefumi Yoshida, Shinya Takaishi, Brian K Breedlove, Zhao-Yang Li, Masahiro Yamashita
Jan 27, 2020
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