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The Primary Care Spend Model
Increased investment in primary care is associated with lower healthcare costs and improved population health. The allocation of scarce resources should be driven by robust models that adequately describe primary care activities...
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Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.
Bram P Prins, Timothy J Mead, Jennifer A Brody, Gardar Sveinbjornsson, Ioanna Ntalla, Nathan A Bihlmeyer, Marten van den Berg, Jette Bork-Jensen, Stefania Cappellani, Stefan Van Duijvenboden, Nikolai T Klena, George C Gabriel, Xiaoqin Liu, Cagri Gulec, Niels Grarup, Jeffrey Haessler, Leanne M Hall, Annamaria Iorio, Aaron Isaacs, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka Lyytikäinen, Jonathan Marten, Hao Mei, Martina Müller-Nurasyid, Michele Orini, Sandosh Padmanabhan, Farid Radmanesh, Julia Ramirez, Antonietta Robino, Molly Schwartz, Jessica van Setten, Albert V Smith, Niek Verweij, Helen R Warren, Stefan Weiss, Alvaro Alonso, David O Arnar, Michiel L Bots, Rudolf A de Boer, Anna F Dominiczak, Mark Eijgelsheim, Patrick T Ellinor, Xiuqing Guo, Stephan B Felix, Tamara B Harris, Caroline Hayward, Susan R Heckbert, Paul L Huang, JW Jukema, Mika Kähönen, Jan A Kors, Pier D Lambiase, Lenore J Launer, Man Li, Allan Linneberg, Christopher P Nelson, Oluf Pedersen, Marco Perez, Annette Peters, Ozren Polasek, Bruce M Psaty, Olli T Raitakari, Kenneth M Rice, Jerome I Rotter, Moritz F Sinner, Elsayed Z Soliman, Tim D Spector, Konstantin Strauch, Unnur Thorsteinsdottir, Andrew Tinker, Stella Trompet, André Uitterlinden, Ilonca Vaartjes, Peter van der Meer, Uwe Völker, Henry Völzke, Melanie Waldenberger, James G Wilson, Zhijun Xie, Folkert W Asselbergs, Marcus Dörr, Cornelia M van Duijn, Paolo Gasparini, Daniel F Gudbjartsson, Vilmundur Gudnason, Torben Hansen, Stefan Kääb, Jørgen K Kanters, Charles Kooperberg, Terho Lehtimäki, Henry J Lin, Steven A Lubitz, Dennis O Mook-Kanamori, Francesco J Conti, Christopher H Newton-Cheh, Jonathan Rosand, Igor Rudan, Nilesh J Samani, Gianfranco Sinagra, Blair H Smith, Hilma Holm, Bruno H Stricker, Sheila Ulivi, Nona Sotoodehnia, Suneel S Apte, Pim van der Harst, Kari Stefansson, Patricia B Munroe, Dan E Arking, Cecilia W Lo, Yalda Jamshidi
Sep 17, 2018
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Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction.
Ioanna Ntalla, Lu-Chen Weng, James H Cartwright, Amelia Weber Hall, Gardar Sveinbjornsson, Nathan R Tucker, Seung Hoan Choi, Mark D Chaffin, Carolina Roselli, Michael R Barnes, Borbala Mifsud, Helen R Warren, Caroline Hayward, Jonathan Marten, James J Cranley, Maria Pina Concas, Paolo Gasparini, Thibaud Boutin, Ivana Kolcic, Ozren Polasek, Igor Rudan, Nathalia M Araujo, Maria Fernanda Lima-Costa, Antonio Luiz P Ribeiro, Renan P Souza, Eduardo Tarazona-Santos, Vilmantas Giedraitis, Erik Ingelsson, Anubha Mahajan, Andrew P Morris, Fabiola del Greco M, Luisa Foco, Martin Gögele, Andrew A Hicks, James P Cook, Lars Lind, Cecilia M Lindgren, Johan Sundström, Christopher P Nelson, Muhammad B Riaz, Nilesh J Samani, Gianfranco Sinagra, Sheila Ulivi, Mika Kähönen, Pashupati P Mishra, Nina Mononen, Kjell Nikus, Mark J Caulfield, Anna Dominiczak, Sandosh Padmanabhan, May E Montasser, Jeff R O'Connell, Kathleen Ryan, Alan R Shuldiner, Stefanie Aeschbacher, David Conen, Lorenz Risch, Sébastien Thériault, Nina Hutri-Kähönen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Olli T Raitakari, Catriona LK Barnes, Harry Campbell, Peter K Joshi, James F Wilson, Aaron Isaacs, Jan A Kors, Cornelia M van Duijn, Paul L Huang, Vilmundur Gudnason, Tamara B Harris, Lenore J Launer, Albert V Smith, Erwin P Bottinger, Ruth JF Loos, Girish N Nadkarni, Michael H Preuss, Adolfo Correa, Hao Mei, James Wilson, Thomas Meitinger, Martina Müller-Nurasyid, Annette Peters, Melanie Waldenberger, Massimo Mangino, Timothy D Spector, Michiel Rienstra, Yordi J van de Vegte, Pim van der Harst, Niek Verweij, Stefan Kääb, Katharina Schramm, Moritz F Sinner, Konstantin Strauch, Michael J Cutler, Diane Fatkin, Barry London, Morten Olesen, Dan M Roden, M Benjamin Shoemaker, J Gustav Smith, Mary L Biggs, Joshua C Bis, Jennifer A Brody, Bruce M Psaty, Kenneth Rice, Nona Sotoodehnia, Alessandro De Grandi, Christian Fuchsberger, Cristian Pattaro, Peter P Pramstaller, Ian Ford, J Wouter Jukema, Peter W Macfarlane, Stella Trompet, Marcus Dörr, Stephan B Felix, Uwe Völker, Stefan Weiss, Aki S Havulinna, Antti Jula, Katri Sääksjärvi, Veikko Salomaa, Xiuqing Guo, Susan R Heckbert, Henry J Lin, Jerome I Rotter, Kent D Taylor, Jie Yao, Renée de Mutsert, Arie C Maan, Dennis O Mook-Kanamori, Raymond Noordam, Francesco Cucca, Jun Ding, Edward G Lakatta, Yong Qian, Kirill V Tarasov, Daniel Levy, Honghuang Lin, Christopher H Newton-Cheh, Kathryn L Lunetta, Alison D Murray, David J Porteous, Blair H Smith, Bruno H Stricker, André Uitterlinden, Marten E van den Berg, Jeffrey Haessler, Rebecca D Jackson, Charles Kooperberg, Ulrike Peters, Alexander P Reiner, Eric A Whitsel, Alvaro Alonso, Dan E Arking, Eric Boerwinkle, Georg B Ehret, Elsayed Z Soliman, Christy L Avery, Stephanie M Gogarten, Kathleen F Kerr, Cathy C Laurie, Amanda A Seyerle, Adrienne Stilp, Solmaz Assa, M Abdullah Said, M Yldau van der Ende, Pier D Lambiase, Michele Orini, Julia Ramirez, Stefan Van Duijvenboden, David O Arnar, Daniel F Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa B Thorolfsdottir, Unnur Thorsteinsdottir, Emelia J Benjamin, Andrew Tinker, Kari Stefansson, Patrick T Ellinor, Yalda Jamshidi, Steven A Lubitz, Patricia B Munroe
Jun 08, 2020
The electrocardiographic PR interval reflects atrioventricular conduction, and is associated with conduction abnormalities, pacemaker implantation, atrial fibrillation (AF), and cardiovascular mortality. Here we report a...
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