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Activation of the TGFβ pathway impairs endothelial to haematopoietic transition.
Özge Vargel, Yang Zhang, Kinga Kosim, Kerstin Ganter, Sophia Foehr, Yannicka Mardenborough, Maya Shvartsman, Anton J Enright, Jeroen Krijgsveld, Christophe Lancrin
Nov 20, 2017
The endothelial to haematopoietic transition (EHT) is a key developmental process where a drastic change of endothelial cell morphology leads to the formation of blood stem and progenitor cells during embryogenesis. As TGFβ...
Animals Cell Differentiation Cell Movement Cell Transdifferentiation Colony-Forming Units Assay Endothelial Cells Extracellular Matrix Gene Expression Profiling Gene Expression Regulation Developmental HMGB Proteins Hematopoiesis Hematopoietic Stem Cells Mice Neovascularization Physiologic SOXF Transcription Factors Signal Transduction Transcriptome Transforming Growth Factor beta