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Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection.
Jessica Sook Yuin Ho, Matthew Angel, Yixuan Ma, Elizabeth Sloan, Guojun Wang, Carles Martinez-Romero, Marta Alenquer, Vladimir Roudko, Liliane Chung, Simin Zheng, Max Chang, Yesai Fstkchyan, Sara Clohisey, Adam M Dinan, James Gibbs, Robert Gifford, Rong Shen, Quan Gu, Nerea Irigoyen, Laura Campisi, Cheng Huang, Nan Zhao, Joshua D Jones, Ingeborg van Knippenberg, Zeyu Zhu, Natasha Moshkina, Léa Meyer, Justine Noel, Zuleyma Peralta, Veronica Rezelj, Robyn Kaake, Brad Rosenberg, Bo Wang, Jiajie Wei, Slobodan Paessler, Helen M Wise, Jeffrey Johnson, Alessandro Vannini, Maria João Amorim, J Kenneth Baillie, Emily R Miraldi, Christopher Benner, Ian Brierley, Paul Digard, Marta Łuksza, Andrew E Firth, Nevan Krogan, Benjamin D Greenbaum, Megan K MacLeod, Harm van Bakel, Adolfo Garcìa-Sastre, Jonathan W Yewdell, Edward Hutchinson, Ivan Marazzi
Jul 06, 2020
RNA viruses are a major human health threat. The life cycles of many highly pathogenic RNA viruses like influenza A virus (IAV) and Lassa virus depends on host mRNA, because viral polymerases cleave 5'-m7G-capped host...
RNA hybrid cap-snatching chimeric proteins gene origination Influenza segmented negative-strand RNA viruses uORFs upstream AUG viral RNA Viral evolution 5' Untranslated Regions Animals Cattle Cell Line Cricetinae Dogs Humans Influenza A virus Mice Mutant Chimeric Proteins Open Reading Frames RNA Caps RNA Virus Infections RNA Viruses RNA Messenger RNA Viral RNA-Dependent RNA Polymerase Recombinant Fusion Proteins Transcription Genetic Viral Proteins Virus Replication