Search
Results: 1123
C-Nucleoside Formation in the Biosynthesis of the Antifungal Malayamycin A.
Streptomyces TruD biosynthetic engineering enoylpyruvyltransferase genome mining nucleoside antibiotic pseudouridine synthase Aminoglycosides Antifungal Agents Bacterial Proteins Biosynthetic Pathways Bridged Bicyclo Compounds Heterocyclic Genome Bacterial Intramolecular Transferases Multigene Family Nucleosides Streptomyces
General tax structures and the Lévy insurance risk model
In the spirit of Albrecher and Hipp (2007), and Albrecher, Renaud, and Zhou (2008) we consider a Levy insurance risk model with tax payments of a more general structure than in the aforementioned papers, which was also...
General tax structures and the Lévy insurance risk model
In the spirit of Albrecher and Hipp (2007), and Albrecher, Renaud, and Zhou (2008) we consider a Levy insurance risk model with tax payments of a more general structure than in the aforementioned papers, which was also...
Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin.
Yongjun Zhou, Annabel C Murphy, Markiyan Samborskyy, Patricia Prediger, Luiz Carlos Dias, Peter F Leadlay
Jun 19, 2015
Evidence for an iterative module in chain elongation on the azalomycin polyketide synthase.
Hui Hong, Yuhui Sun, Yongjun Zhou, Emily Stephens, Markiyan Samborskyy, Peter F Leadlay
Oct 10, 2018
The assembly-line synthases that produce bacterial polyketide natural products follow a modular paradigm in which each round of chain extension is catalysed by a different set or module of enzymes. Examples of deviation from...
Biosynthesis of depsipeptides with a 3-hydroxybenzoate moiety and selective anticancer activities involves a chorismatase.
Yaoyao Shen, Fan Sun, Liu Zhang, Yijia Cheng, Hongrui Zhu, Shu-Ping Wang, Wei-Hua Jiao, Peter F Leadlay, Yongjun Zhou, Hou-Wen Lin
Sep 11, 2020
Neoantimycins are anticancer compounds of 15-membered ring antimycin-type depsipeptides. They are biosynthesized by a hybrid multimodular protein complex of nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS)...
Antibiotics anticancer drug chorismatase enzyme catalysis natural product biosynthesis non-ribosomal peptide synthetase (NRPS) polyketide synthase (PKS) Secondary Metabolism unantimycins Antibiotics Antineoplastic Bacterial Proteins Cell Line Tumor Cell Survival Depsipeptides Humans Hydroxybenzoates Organic Chemicals Polyketide Synthases Streptomyces
Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition.
Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun
Feb 09, 2023
Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition.
Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Yangning Sun, Zhou Hong, Chuan Dong, Peter F Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun
Mar 07, 2023
Modular polyketide synthase (PKS) is an ingenious core machine that catalyzes abundant polyketides in nature. Exploring interactions among modules in PKS is very important for understanding the overall biosynthetic process and...
Published by: Nature Communications
Study on Influences of Fringing Reef on Harbor Oscillations Triggered by N-Waves
Influences of topographic variations of the offshore fringing reef on the harbor oscillations excited by incident N-waves with different amplitudes and waveform types are studied for the first time. Both the propagation of...
Fringing-reef topography FUNWAVE-TVD Harbor oscillations N-waves Numerical simulations /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Study on Influences of Fringing Reef on Harbor Oscillations Triggered by N-Waves
Influences of topographic variations of the offshore fringing reef on the harbor oscillations excited by incident N-waves with different amplitudes and waveform types are studied for the first time. Both the propagation of...
Fringing-reef topography FUNWAVE-TVD Harbor oscillations N-waves Numerical simulations /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy
Research on supporting mechanism of ancillary service of PV system to grid energy efficiency based on multi-time and space-time operation.
Under the background of high-energy penetration of new energy into the power grid, this paper takes the ancillary service capability of photovoltaic energy integrated into the grid as the starting point and builds a photovoltaic...
Mechanistic insights into the novel glucose-sensitive behavior of P(NIPAM-co-2-AAPBA)
A glucose-sensitive polymer, poly(N-isopropylacrylamide-co-2-acrylamidophenylboronic acid) (P(NIPAM-co-2-AAPBA)), was synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization. Addition of glucose...
Mechanistic insights into the novel glucose-sensitive behavior of P(NIPAM-co-2-AAPBA)
A glucose-sensitive polymer, poly(N-isopropylacrylamide-co-2-acrylamidophenylboronic acid) (P(NIPAM-co-2-AAPBA)), was synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization. Addition of glucose...
Research on supporting mechanism of ancillary service of PV system to grid energy efficiency based on multi-time and space-time operation.
Under the background of high-energy penetration of new energy into the power grid, this paper takes the ancillary service capability of photovoltaic energy integrated into the grid as the starting point and builds a photovoltaic...
Harmonic Analyses of Hydrodynamic Characteristics for Gap Resonance Between Fixed Box and Vertical Wall
Two marine structures arranged side by side with a narrow gap may suffer from violent free-surface resonance, which would cause green water on deck, dramatically raise hydrodynamic loads on structures and seriously threaten...
Gap resonance harmonic analyses OpenFOAM® resonant wave height Wave loads /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/clean_water_and_sanitation name=SDG 6 - Clean Water and Sanitation /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue.
Maria Grandoch, Ulrich Flögel, Sam Virtue, Julia K Maier, Tomas Jelenik, Christina Kohlmorgen, Kathrin Feldmann, Yanina Ostendorf, Tamara R Castañeda, Zhou Zhou, Yu Yamaguchi, Emmani BM Nascimento, Vivekananda G Sunkari, Christine Goy, Martina Kinzig, Fritz Sörgel, Paul L Bollyky, Patrick Schrauwen, Hadi Al-Hasani, Michael Roden, Susanne Keipert, Antonio Vidal-Puig, Martin Jastroch, Judith Haendeler, Jens W Fischer
Oct 09, 2020
Therapeutic increase of brown adipose tissue (BAT) thermogenesis is of great interest as BAT activation counteracts obesity and insulin resistance. Hyaluronan (HA) is a glycosaminoglycan, found in the extracellular matrix, which...
Conserved roles of C. elegans and human MANFs in sulfatide binding and cytoprotection.
Meirong Bai, Roman Vozdek, Aleš Hnízda, Chenxiao Jiang, Bingying Wang, Ladislav Kuchar, Tiejun Li, Yuefan Zhang, Chase Wood, Liang Feng, Yongjun Dang, Dengke K Ma
Sep 20, 2018
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) protein that can be secreted and protects dopamine neurons and cardiomyocytes from ER stress and apoptosis. The mechanism of action of...
Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils.
Yang Song, Thomas CT Michaels, Qingming Ma, Zhou Liu, Hao Yuan, Shuichi Takayama, Tuomas PJ Knowles, Ho Cheung Shum
Sep 29, 2018
Networks of natural protein nanofibrils, such as cytoskeletal filaments, control the shape and the division of cells, yet mimicking this functionality in a synthetic setting has proved challenging. Here, we demonstrate that...
Harmonic Analyses of Hydrodynamic Characteristics for Gap Resonance Between Fixed Box and Vertical Wall
Two marine structures arranged side by side with a narrow gap may suffer from violent free-surface resonance, which would cause green water on deck, dramatically raise hydrodynamic loads on structures and seriously threaten...
Gap resonance harmonic analyses OpenFOAM® resonant wave height Wave loads /dk/atira/pure/subjectarea/asjc/1900/1910 name=Oceanography /dk/atira/pure/subjectarea/asjc/2100/2105 name=Renewable Energy, Sustainability and the Environment /dk/atira/pure/subjectarea/asjc/2200/2212 name=Ocean Engineering /dk/atira/pure/subjectarea/asjc/2200/2210 name=Mechanical Engineering /dk/atira/pure/sustainabledevelopmentgoals/clean_water_and_sanitation name=SDG 6 - Clean Water and Sanitation /dk/atira/pure/sustainabledevelopmentgoals/affordable_and_clean_energy name=SDG 7 - Affordable and Clean Energy /dk/atira/pure/sustainabledevelopmentgoals/life_below_water name=SDG 14 - Life Below Water
Autocalibration of accelerometer data for free-living physical activity assessment using local gravity and temperature
Vincent T van Hees, Zhou Fang, Joss Langford, Felix Assah, Anwar Mohammad, Inacio CM da Silva, Michael I Trenell, Tom White, Nicholas J Wareham, Søren Brage
Aug 22, 2014
Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells
Dan Zhao, Hai Hao Han, Ling Zhu, Fang Zhou Xu, Xing Yu Ma, Jia Li, Tony D. James, Yi Zang, Xiao Peng He, Chengyun Wang
Sep 20, 2021
With this research, we have developed two long-wavelength theranostic probes (DCMT and DCMC) with aggregation-induced emission (AIE)-based properties for image-guided photodynamic therapy (PDT) of hepatoma cells. Introduction...
aggregation-induced emission (AIE) Mitochondria photodynamic therapy (PDT) photosensitizer theranostic probe /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2500/2502 name=Biomaterials /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2704 name=Biochemistry, medical /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
Long-Wavelength AIE-Based Fluorescent Probes for Mitochondria-Targeted Imaging and Photodynamic Therapy of Hepatoma Cells
Dan Zhao, Hai Hao Han, Ling Zhu, Fang Zhou Xu, Xing Yu Ma, Jia Li, Tony D. James, Yi Zang, Xiao Peng He, Chengyun Wang
Sep 20, 2021
With this research, we have developed two long-wavelength theranostic probes (DCMT and DCMC) with aggregation-induced emission (AIE)-based properties for image-guided photodynamic therapy (PDT) of hepatoma cells. Introduction...
aggregation-induced emission (AIE) Mitochondria photodynamic therapy (PDT) photosensitizer theranostic probe /dk/atira/pure/subjectarea/asjc/1600/1600 name=General Chemistry /dk/atira/pure/subjectarea/asjc/2500/2502 name=Biomaterials /dk/atira/pure/subjectarea/asjc/2200/2204 name=Biomedical Engineering /dk/atira/pure/subjectarea/asjc/2700/2704 name=Biochemistry, medical /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being name=SDG 3 - Good Health and Well-being
REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells.
Helle F Jørgensen, Anna Terry, Chiara Beretta, C Filipe Pereira, Marion Leleu, Zhou-Feng Chen, Claire Kelly, Matthias Merkenschlager, Amanda G Fisher
May 04, 2018
REST is a transcriptional repressor that targets a group of neuronal genes in non-neuronal cells. In embryonic stem (ES) cells, REST has been implicated in controlling the expression of transcription factor genes that are...
GC content shapes mRNA storage and decay in human cells
Maïté Courel, Yves Clément, Clémentine Bossevain, Dominika Foretek, Olivia Vidal Cruchez, Zhou Yi, Marianne Bénard, Marie-Noëlle Benassy, Michel Kress, Caroline Vindry, Michèle Ernoult-Lange, Christophe Antoniewski, Antonin Morillon, Patrick Brest, Arnaud Hubstenberger, Hugues Roest Crollius, Nancy Standart, Dominique Weil
Jan 07, 2020
|
|< |
< |
1 |