Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient.
Joep Beumer,
Benedetta Artegiani,
Yorick Post,
Frank Reimann,
Fiona Gribble,
Thuc Nghi Nguyen,
Hongkui Zeng,
Maaike Van den Born,
Johan H van Es,
Hans Clevers
Oct 19, 2018
Enteroendocrine cells (EECs) control a wide range of physiological processes linked to metabolism1. We show that EEC hormones are differentially expressed between crypts (for example, Glp1) and villi (for example, secretin). As...