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Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Jeonghwan Youk, Taewoo Kim, Kelly V Evans, Young-Il Jeong, Yongsuk Hur, Seon Pyo Hong, Je Hyoung Kim, Kijong Yi, Su Yeon Kim, Kwon Joong Na, Thomas Bleazard, Ho Min Kim, Mick Fellows, Krishnaa T Mahbubani, Kourosh Saeb-Parsy, Seon Young Kim, Young Tae Kim, Gou Young Koh, Byeong-Sun Choi, Young Seok Ju, Joo-Hyeon Lee
Oct 15, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the cause of a present pandemic, infects human lung alveolar type 2 (hAT2) cells. Characterizing pathogenesis is crucial for developing vaccines and...
3D cultures covid-19 SARS-CoV-2 alveolar stem cells Electron microscopy human alveolar type 2 cells Infection interferon interferon-stimulating genes Single-cell RNA-seq covid-19 Cell Culture Techniques Culture Media Humans Interferons Models Biological Pulmonary Alveoli SARS-CoV-2 Stem Cells Transcriptome Virus Internalization Virus Replication
Comprehensive molecular characterization of mitochondrial genomes in human cancers
Yuan Yuan, Young Seok Ju, Youngwook Kim, Jun Li, Yumeng Wang, Christopher J. Yoon, Yang Yang, Inigo Martincorena, Chad J. Creighton, John N. Weinstein, Yanxun Xu, Leng Han, Hyung-Lae Kim, Hidewaki Nakagawa, Keunchil Park, Peter J. Campbell, Han Liang
Feb 04, 2021
Abstract: Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium...
“I think we need to empower people to manage it better themselves”:
Objectives: To elicit healthcare practitioners’ views on treatment following sport-related knee injury in young adults (18–35) and the potential for individuals to self-manage joint health. Design: Semi-structured interviews...
Why young people stop taking their attention deficit hyperactivity disorder medication
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that can persist into adulthood. Young people often stop taking ADHD medication during adolescence despite evidence that...
Comprehensive molecular characterization of mitochondrial genomes in human cancers.
Yuan Yuan, Young Seok Ju, Youngwook Kim, Jun Li, Yumeng Wang, Christopher J Yoon, Yang Yang, Inigo Martincorena, Chad J Creighton, John N Weinstein, Yanxun Xu, Leng Han, Hyung-Lae Kim, Hidewaki Nakagawa, Keunchil Park, Peter J Campbell, Han Liang, PCAWG Consortium
Aug 02, 2021
Mitochondria are essential cellular organelles that play critical roles in cancer. Here, as part of the International Cancer Genome Consortium/The Cancer Genome Atlas Pan-Cancer Analysis of Whole Genomes Consortium, which...
Needs of Young African Neurosurgeons and Residents
Ulrick S. Kanmounye, Faith C. Robertson, Nqobile S. Thango, Alvin Nah Doe, Nourou Dine Adeniran Bankole, Pape Aicha Ginette, Solomon Ondoma, James A. Balogun, Isabella Opoku, Luxwell Jokonya, Thioub Mbaye, Zarina A. Shabhay, Ahmed M. Ashour, Ana Cristina Veiga Silva, Beverly Cheserem, Claire Karekezi, Fahd Derkaoui Hassani, Nesrine Mentri, Tsegazeab Laeke, Abenezer Tirsit Aklilu, Samuila Sanoussi, Aaron Musara, Jeff Ntalaja, Peter Ssenyonga, Souad Bakhti, Najia El Abbadi, Muhammad Raji Mahmud, Nasser M. F. El-Ghandour, Amro Al-Habib, Angelos G. Kolias, Franco Servadei, Graham Fieggen, Mahmood Qureshi, Ignatius Esene, CAANS Young Neurosurgeons Committee and WFNS Young Neurosurgeons Committee
Jun 11, 2021
Introduction: Africa has many untreated neurosurgical cases due to limited access to safe, affordable, and timely care. In this study, we surveyed young African neurosurgeons and trainees to identify challenges to training and...
“I think we need to empower people to manage it better themselves”:
Objectives: To elicit healthcare practitioners’ views on treatment following sport-related knee injury in young adults (18–35) and the potential for individuals to self-manage joint health. Design: Semi-structured interviews...
Needs of Young African Neurosurgeons and Residents
Ulrick S Kanmounye, Faith C Robertson, Nqobile S Thango, Alvin Nah Doe, Nourou Dine Adeniran Bankole, Pape Aicha Ginette, Solomon Ondoma, James A Balogun, Isabella Opoku, Luxwell Jokonya, Thioub Mbaye, Zarina A Shabhay, Ahmed M Ashour, Ana Cristina Veiga Silva, Beverly Cheserem, Claire Karekezi, Fahd Derkaoui Hassani, Nesrine Mentri, Tsegazeab Laeke, Abenezer Tirsit Aklilu, Samuila Sanoussi, Aaron Musara, Jeff Ntalaja, Peter Ssenyonga, Souad Bakhti, Najia El Abbadi, Muhammad Raji Mahmud, Nasser MF El-Ghandour, Amro Al-Habib, Angelos G Kolias, Franco Servadei, Graham Fieggen, Mahmood Qureshi, Ignatius Esene, CAANS Young Neurosurgeons Committee and WFNS Young Neurosurgeons Committee
Oct 20, 2021
Introduction: Africa has many untreated neurosurgical cases due to limited access to safe, affordable, and timely care. In this study, we surveyed young African neurosurgeons and trainees to identify challenges to training and...
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.
Han Seok Koh, Chi Young Chang, Sae-Bom Jeon, Hee Jung Yoon, Ye-Hyeon Ahn, Hyung-Seok Kim, In-Hoo Kim, Sung Ho Jeon, Randall S Johnson, Eun Jung Park
Mar 13, 2020
Inflammation is closely related to the extent of damage following cerebral ischaemia, and the targeting of this inflammation has emerged as a promising therapeutic strategy. Here, we present that hypoxia-induced glial T-cell...
Animals Astrocytes Brain Carotid Artery Common Cell Movement Cells Cultured Hepatitis A Virus Cellular Receptor 2 Hypoxia-Inducible Factor 1 alpha Subunit Hypoxia-Ischemia Brain Immunohistochemistry In Vitro Techniques Inflammation Ligation Magnetic Resonance Imaging Mesencephalon Mice Microglia Neuroglia Neutrophils RNA Messenger Receptors Virus Reverse Transcriptase Polymerase Chain Reaction
Preventing Smoking in Young People
Lindsay Richardson, Natalie Hemsing, Lorraine Greaves, Sunaina Assanand, Patrice Allen, Lucy McCullough, Linda Bauld, Karin Humphries, Amanda Amos
Jan 01, 0001
Aims: To examine existing evidence on the effectiveness of interventions that are designed to prevent the illegal sale of tobacco to young people. The review considers specific sub-questions related to the factors that might...
Locating young refugees historically
Jason Hart
Apr 10, 2014
Nowadays humanitarian organisations are often keen to engage young displaced people in programmatic efforts. In such efforts attention is commonly paid to the impact of the social dynamics of gender. However, similar...
GPs role identifying young people who self-harm
Background: Self-harm is common among young people and is evident in increasingly younger age groups. Many young people who self-harm do visit their General Practitioner (GP) but do not access specialist support. GP’s can find...
Locating young refugees historically
Jason Hart
Apr 10, 2014
Nowadays humanitarian organisations are often keen to engage young displaced people in programmatic efforts. In such efforts attention is commonly paid to the impact of the social dynamics of gender. However, similar...
Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells
Young, J.W., and Steinman, R.M. Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells. J. Exp. Med. 171: 1315-1332, 1990
Published by: The Rockefeller University Press
Social networking and young adults’ drinking practices
Objectives: Understandings of health behaviors can be enriched by using innovative qualitative research designs. We illustrate this with a project that used multiple qualitative methods to explore the confluence of young adults’...
Social networking and young adults’ drinking practices
Objectives: Understandings of health behaviors can be enriched by using innovative qualitative research designs. We illustrate this with a project that used multiple qualitative methods to explore the confluence of young adults’...
Preventing Smoking in Young People
Lindsay Richardson, Natalie Hemsing, Lorraine Greaves, Sunaina Assanand, Patrice Allen, Lucy McCullough, Linda Bauld, Karin Humphries, Amanda Amos
Jan 01, 0001
Aims: To examine existing evidence on the effectiveness of interventions that are designed to prevent the illegal sale of tobacco to young people. The review considers specific sub-questions related to the factors that might...
Too Young to Be Mad
Maria Liegghio
Dec 29, 2016
In this paper, the psychiatrization of children and youth is explored, as well as their representation within Mad and Disability Studies. Presented are the outcomes of a photo voice project conducted with seven (N=7) youths...
Published by: Memorial University of Newfoundland
The Dimensionality of Proposed DSM-5 PTSD Symptoms in Trauma-Exposed Young Children.
Anna McKinnon, Michael S Scheeringa, Richard Meiser-Stedman, Peter Watson, Alexandra De Young, Tim Dalgleish
Jun 20, 2019
A subtype of the posttraumatic stress disorder diagnosis for children 6 years and younger (PTSD-6Y) was introduced in the Diagnostic and Statistical Manual, Fifth Edition (DSM-5). This study utilized confirmatory factor analytic...
DSM-5 Factor Analysis Posttraumatic stress disorder young children Affective Symptoms Child Child Preschool Diagnostic and Statistical Manual of Mental Disorders Female Humans Male Models Statistical Psychological Trauma Reproducibility of Results Sensitivity and Specificity Stress Disorders Post-Traumatic
JEFFREY RAVETCH AND MICHAEL YOUNG
The Rockefeller University
Jan 01, 0001
Congratulations to Jeffrey Ravetch and Michael Young, recipients of the 2012 Canada Gairdner International Award
Published by: The Rockefeller University
Educational Expansion and Overeducation of young graduates:
This study uses quarterly EU Labour Force Survey data for 30 countries over the period 2000 to 2016 to examine the relationship between changes in the composition of educational attainment and overeducation rates among new...
Educational Expansion and Overeducation of young graduates:
This study uses quarterly EU Labour Force Survey data for 30 countries over the period 2000 to 2016 to examine the relationship between changes in the composition of educational attainment and overeducation rates among new...
Airway secretory cell fate conversion via YAP‐mTORC1‐dependent essential amino acid metabolism
Hae Yon Jeon, Jinwook Choi, Lianne Kraaier, Young Hoon Kim, David Eisenbarth, Kijong Yi, Ju‐Gyeong Kang, Jin Woo Kim, Hyo Sup Shim, Joo‐Hyeon Lee, Dae‐Sik Lim
Mar 14, 2022
Healthcare transition among young adults with childhood-onset chronic pain
Caitlin Murray, Lexa Murphy, Abbie Jordan, Michelle Owens, Dorothy McLeod, Tonya Palermo
Aug 31, 2022
Chronic pain extends from childhood to adulthood for many young people. The transition from pediatric to adult care is a critical, yet understudied, healthcare task facing young adults with chronic pain. The aims of this...
Children, young people and alcohol
Richard Velleman
Nov 01, 2009
Two linked research reviews examine: how young people acquire their knowledge, attitudes, expectations, and intentions about alcohol; and what interventions work best to prevent excessive use of alcohol.
Published by: Joseph Rowntree Foundation
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