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Results: 162
Mutational signatures
Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and understanding the etiologies of cancer-derived mutational signatures...
Life duration of bike sharing systems
Many factors have been advanced to predicate the sustainability of bike sharing system (BSS) and bike sharing usage, such as fleet size, number of docking stations, payment type and financial support, but there have been few...
Bike sharing Generalised linear model Influence factors infrastructure /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/3300/3313 name=Transportation /dk/atira/pure/subjectarea/asjc/3300/3322 name=Urban Studies /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
Stretch reflex improves rolling stability during hopping of a decerebrate biped system.
Conformation control of the histidine kinase BceS of <i>Bacillus subtilis</i> by its cognate ABC-transporter facilitates need-based activation of antibiotic resistance
Bacteria closely control gene expression to ensure optimal physiological responses to their environment. Such careful gene expression can minimize the fitness cost associated with antibiotic resistance. We previously described a...
Life duration of bike sharing systems
Many factors have been advanced to predicate the sustainability of bike sharing system (BSS) and bike sharing usage, such as fleet size, number of docking stations, payment type and financial support, but there have been few...
Bike sharing Generalised linear model Influence factors infrastructure /dk/atira/pure/subjectarea/asjc/3300/3305 name=Geography, Planning and Development /dk/atira/pure/subjectarea/asjc/3300/3313 name=Transportation /dk/atira/pure/subjectarea/asjc/3300/3322 name=Urban Studies /dk/atira/pure/sustainabledevelopmentgoals/sustainable_cities_and_communities name=SDG 11 - Sustainable Cities and Communities
Mutational signatures
Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and understanding the etiologies of cancer-derived mutational signatures...
Published by: Genome biology
Stabilizing multiple topological fermions on a quantum computer
Abstract In classical and single-particle settings, non-trivial band topology always gives rise to robust boundary modes. For quantum many-body systems, however, multiple topological fermions are...
Strategy of Electrolyte Design
Chenghua Wang, Huiyu Huang, Xueyan Sun, Xiaobin Deng, Yuan Lei, Wenbing Hao, Yilun Liu, Xi Chen, Wei Zhao
Apr 05, 2023
The zinc-air batteries (ZABs) are regarded as the most potential energy storage device for the next generation. However, the zinc anode passivation and hydrogen evolution reaction (HER) in alkaline electrolyte situations inhibit...
Modelling of the cancer cell cycle as a tool for rational drug development
The dynamic of cancer is intimately linked to a dysregulation of the cell cycle and signalling pathways. It has been argued that selectivity of treatments could exploit loss of checkpoint function in cancer cells, a concept...
Prediction and identification of synergistic compound combinations against pancreatic cancer cells.
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L Bramhall, Tai-Ping Fan, Andreas Bender
Nov 22, 2021
Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations...
Lightning Sferics
Zhongjian Liu, Kuang Liang Koh, Andrew Mezentsev, Sven Erik Enno, Jacqueline Sugier, Martin Fullekrug
May 22, 2018
Analysis of very low frequency lightning waveforms, or radio sferics, can contribute to research into lower ionosphere perturbations and the corresponding atmospheric chemistry. Lightning waveforms can also be characterized...
atmospheric and space electricity Complex waveform Instantaneous frequency Instantaneous phase Lightning discharge Sferics /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/1900/1900 name=General Earth and Planetary Sciences /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
Plasma adiponectin levels and type 2 diabetes risk
Yeli Wang, Rui-Wei Meng, Setor K Kunutsor, Rajiv Chowdhury, Jian-Min Yuan, Woon-Puay Koh, An Pan
Jun 04, 2018
Results from previous prospective studies assessing the relation between adiponectin and type 2 diabetes (T2D) were not entirely consistent, and evidence in Chinese population is scarce. Moreover, the last meta-analysis did not...
The Abbreviated Maslach Burnout Inventory Can Overestimate Burnout
Wan Yen Lim, John Ong, Sharon Ong, Ying Hao, Hairil Rizal Abdullah, Darren Lk Koh, Un Sam May Mok
Dec 27, 2019
The Maslach Burnout Inventory for healthcare professionals (MBI-HSS) and its abbreviated version (aMBI), are the most common tools to detect burnout in clinicians. A wide range in burnout prevalence is reported in...
Conformation control of the histidine kinase BceS of <i>Bacillus subtilis</i> by its cognate ABC-transporter facilitates need-based activation of antibiotic resistance
Bacteria closely control gene expression to ensure optimal physiological responses to their environment. Such careful gene expression can minimize the fitness cost associated with antibiotic resistance. We previously described a...
Lightning Sferics
Zhongjian Liu, Kuang Liang Koh, Andrew Mezentsev, Sven Erik Enno, Jacqueline Sugier, Martin Fullekrug
May 22, 2018
Analysis of very low frequency lightning waveforms, or radio sferics, can contribute to research into lower ionosphere perturbations and the corresponding atmospheric chemistry. Lightning waveforms can also be characterized...
atmospheric and space electricity Complex waveform Instantaneous frequency Instantaneous phase Lightning discharge Sferics /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/1900/1900 name=General Earth and Planetary Sciences /dk/atira/pure/subjectarea/asjc/2200/2208 name=Electrical and Electronic Engineering
Transcription-coupled repair and mismatch repair contribute towards preserving genome integrity at mononucleotide repeat tracts.
Ilias Georgakopoulos-Soares, Gene Koh, Sophie E Momen, Josef Jiricny, Martin Hemberg, Serena Nik-Zainal
Mar 31, 2020
Amino Acid Motifs Computational Biology DNA Breaks Double-Stranded DNA Mutational Analysis DNA Repair DNA Replication Gene Deletion Gene Expression Regulation Neoplastic genetic variation Genome Human Genomics Humans INDEL Mutation Mutagenesis Neoplasms Polynucleotides Repetitive Sequences Nucleic Acid Sequence Analysis RNA Transcription Genetic
Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.
Siang-Boon Koh, Yann Wallez, Charles R Dunlop, Sandra Bernaldo de Quirós Fernández, Tashinga E Bapiro, Frances M Richards, Duncan I Jodrell
Jun 29, 2018
Combination of cytotoxic therapy with emerging DNA damage response inhibitors (DDRi) has been limited by tolerability issues. However, the goal of most combination trials has been to administer DDRi with standard-of-care doses...
Animals Antineoplastic Combined Chemotherapy Protocols Cell Cycle Proteins Cell Line Tumor Cell Proliferation Checkpoint Kinase 1 DNA Damage DNA Replication Deoxycytidine Drug Synergism Female Humans Mice Mice Inbred BALB C Mice Nude Nuclear Proteins Protein-Tyrosine Kinases Xenograft Model Antitumor Assays Gemcitabine
CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus.
Siang-Boon Koh, Aurélie Courtin, Richard J Boyce, Robert G Boyle, Frances M Richards, Duncan I Jodrell
Jul 02, 2015
The Effect of Strain Rate on the Tensile Deformation Behavior of Single Crystal, Ni-Based Superalloys
Abstract Single crystal Nickel-based superalloys exhibit an anomalous yield point, the yield stress increasing with temperature to a maximum at around 750 ºC. Here, we demonstrate in the alloy...
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