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Results: 53
Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.
Alisa F Zyryanova, Félix Weis, Alexandre Faille, Akeel Abo Alard, Ana Crespillo-Casado, Yusuke Sekine, Heather P Harding, Felicity Allen, Leopold Parts, Christophe Fromont, Peter M Fischer, Alan J Warren, David Ron
Apr 04, 2018
Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis.
Wei Yung Ding, Hui Ting Ong, Yusuke Hara, Jantana Wongsantichon, Yusuke Toyama, Robert C Robinson, François Nédélec, Ronen Zaidel-Bar
Jul 29, 2020
The cell cortex is essential to maintain animal cell shape, and contractile forces generated within it by nonmuscle myosin II (NMY-2) drive cellular morphogenetic processes such as cytokinesis. The role of actin cross-linking...
Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome
Functional comparison of the mouse DC-SIGN, SIGNR1, SIGNR3 and Langerin, C-type lectins
The mouse (m) DC-SIGN family consists of several homologous type II transmembrane proteins located in close proximity on chromosome 8 and having a single carboxyl terminal carbohydrate recognition domain. We first used...
Published by: Rockefeller University
A 1-hydroxy-2,3,1-benzodiazaborine-containing π-conjugated system
Our interest in the functionalization of [sbnd]OH-substituted azaborines prompted us to synthesize a 1-hydroxy-2,3,1-benzodiazaborine conjugated with 1,8-naphthalimide 1. Its fluorescence was dramatically affected by the...
Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells
Engagement of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) by receptor-interacting protein 2 (RIP2) is insufficient for signal transduction.
Caspase Death Domain Inflammation innate immunity NF-κB (NF-κB) Nod-like Receptor (NLR) Protein Kinase Protein-Protein Interaction Signal Transduction HEK293 Cells Humans Mutation Nod1 Signaling Adaptor Protein Protein Multimerization Protein Structure Secondary Protein Structure Tertiary Receptor-Interacting Protein Serine-Threonine Kinase 2 Signal Transduction
Contribution of <i>sox9b</i> to pigment cell formation in medaka fish
Yuri Tsunogai, Motohiro Miyadai, Yusuke Nagao, Keisuke Sugiwaka, Robert N Kelsh, Masahiko Hibi, Hisashi Hashimoto
Dec 31, 2021
SoxE-type transcription factors, Sox10 and Sox9, are key regulators of the development of neural crest cells. Sox10 specifies pigment cell, glial, and neuronal lineages, whereas Sox9 is reportedly closely associated with...
A 1-hydroxy-2,3,1-benzodiazaborine-containing π-conjugated system
Our interest in the functionalization of [sbnd]OH-substituted azaborines prompted us to synthesize a 1-hydroxy-2,3,1-benzodiazaborine conjugated with 1,8-naphthalimide 1. Its fluorescence was dramatically affected by the...
The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.
Ryotaro Nishi, Paul WG Wijnhoven, Yusuke Kimura, Misaki Matsui, Rebecca Konietzny, Qian Wu, Keisuke Nakamura, Tom L Blundell, Benedikt M Kessler
Feb 14, 2019
Automatic Detection of Microaneurysms in Fundus Images
Early detection and treatment of diabetic retinopathy can delay blindness and improve quality of life for diabetic patients. It is difficult to detect early symptoms of diabetic retinopathy, which is presented by few...
Systems & Software Design Computer Science and Information Technology Systems and Software Engineering
Published by: IGI Global Scientific Publishing
Confined diffusion of transmembrane proteins and lipids induced by the same actin meshwork lining the plasma membrane.
Takahiro K Fujiwara, Kokoro Iwasawa, Ziya Kalay, Taka A Tsunoyama, Yusuke Watanabe, Yasuhiro M Umemura, Hideji Murakoshi, Kenichi GN Suzuki, Yuri L Nemoto, Nobuhiro Morone, Akihiro Kusumi
May 28, 2019
The mechanisms by which the diffusion rate in the plasma membrane (PM) is regulated remain unresolved, despite their importance in spatially regulating the reaction rates in the PM. Proposed models include entrapment in...
Towards prognostic functional brain biomarkers for cervical myelopathy
Shota Takenaka, Shigeyuki Kan, Ben Seymour, Takahiro Makino, Yusuke Sakai, Junichi Kushioka, Hisashi Tanaka, Yoshiyuki Watanabe, Masahiko Shibata, Hideki Yoshikawa, Takashi Kaito
Jul 17, 2020
Abstract: Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential...
Towards prognostic functional brain biomarkers for cervical myelopathy
Shota Takenaka, Shigeyuki Kan, Ben Seymour, Takahiro Makino, Yusuke Sakai, Junichi Kushioka, Hisashi Tanaka, Yoshiyuki Watanabe, Masahiko Shibata, Hideki Yoshikawa, Takashi Kaito
Aug 02, 2019
Recently, there has been increasing interest in strategies to predict neurological recovery in cervical myelopathy (CM) based on clinical images of the cervical spine. In this study, we aimed to explore potential preoperative...
Contribution of <i>sox9b</i> to pigment cell formation in medaka fish
Yuri Tsunogai, Motohiro Miyadai, Yusuke Nagao, Keisuke Sugiwaka, Robert N Kelsh, Masahiko Hibi, Hisashi Hashimoto
Dec 31, 2021
SoxE-type transcription factors, Sox10 and Sox9, are key regulators of the development of neural crest cells. Sox10 specifies pigment cell, glial, and neuronal lineages, whereas Sox9 is reportedly closely associated with...
Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis
Shinya Hayami, Masanori Yoshimatsu, Abhimanyu Veerakumarasivam, Motoko Unoki, Yukiko Iwai, Tatsuhiko Tsunoda, Helen I Field, John D Kelly, David E Neal, Hiroki Yamaue, Bruce AJ Ponder, Yusuke Nakamura, Ryuji Hamamoto
Sep 12, 2011
Cell Line Tumor Cell Proliferation E2F1 Transcription Factor E2F2 Transcription Factor Female Gene Expression Regulation Neoplastic Humans Jumonji Domain-Containing Histone Demethylases Male Nuclear Proteins Oligonucleotide Array Sequence Analysis Precancerous Conditions Repressor Proteins Reproducibility of Results Retinoblastoma Protein Signal Transduction Tissue Array Analysis Up-Regulation
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis
Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I. Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Sep 15, 2020
A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Sep 15, 2021
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Felix A Dingler, Meng Wang, Anfeng Mu, Christopher L Millington, Nina Oberbeck, Sam Watcham, Lucas B Pontel, Ashley N Kamimae-Lanning, Frederic Langevin, Camille Nadler, Rebecca L Cordell, Paul S Monks, Rui Yu, Nicola K Wilson, Asuka Hira, Kenichi Yoshida, Minako Mori, Yusuke Okamoto, Yusuke Okuno, Hideki Muramatsu, Yuichi Shiraishi, Masayuki Kobayashi, Toshinori Moriguchi, Tomoo Osumi, Motohiro Kato, Satoru Miyano, Etsuro Ito, Seiji Kojima, Hiromasa Yabe, Miharu Yabe, Keitaro Matsuo, Seishi Ogawa, Berthold Göttgens, Michael RG Hodskinson, Minoru Takata, Ketan J Patel
Nov 06, 2020
Reactive aldehydes arise as by-products of metabolism and are normally cleared by multiple families of enzymes. We find that mice lacking two aldehyde detoxifying enzymes, mitochondrial ALDH2 and cytoplasmic ADH5, have greatly...
DNA Damage Ageing bone marrow failure Cancer Formaldehyde Hematopoiesis Hematopoietic Stem Cells immunodeficiency Mutagenesis oncometabolite Adolescent Alcohol Dehydrogenase Aldehyde Dehydrogenase Mitochondrial Aldehydes Animals Child Child Preschool DNA Adducts DNA Damage DNA Repair Female Formaldehyde Hematopoiesis Hematopoietic Stem Cells Humans Infant Leukemia Male Mice Mutation Substrate Specificity
A global synthesis of high-resolution stable isotope data from benthic foraminifera of the last deglaciation.
Juan Muglia, Stefan Mulitza, Janne Repschläger, Andreas Schmittner, Lester Lembke-Jene, Lorraine Lisiecki, Alan Mix, Rajeev Saraswat, Elizabeth Sikes, Claire Waelbroeck, Julia Gottschalk, Jörg Lippold, David Lund, Gema Martinez-Mendez, Elisabeth Michel, Francesco Muschitiello, Sushant Naik, Yusuke Okazaki, Lowell Stott, Antje Voelker, Ning Zhao
Apr 11, 2023
We present the first version of the Ocean Circulation and Carbon Cycling (OC3) working group database, of oxygen and carbon stable isotope ratios from benthic foraminifera in deep ocean sediment cores from the Last Glacial...
Published by: Scientific data
A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement.
Sylvie Bannwarth, Samira Ait-El-Mkadem, Annabelle Chaussenot, Emmanuelle C Genin, Sandra Lacas-Gervais, Konstantina Fragaki, Laetitia Berg-Alonso, Yusuke Kageyama, Valérie Serre, David G Moore, Annie Verschueren, Cécile Rouzier, Isabelle Le Ber, Gaëlle Augé, Charlotte Cochaud, Françoise Lespinasse, Karine N'Guyen, Anne de Septenville, Alexis Brice, Patrick Yu-Wai-Man, Hiromi Sesaki, Jean Pouget, Véronique Paquis-Flucklinger
Mar 18, 2019
Mitochondrial DNA instability disorders are responsible for a large clinical spectrum, among which amyotrophic lateral sclerosis-like symptoms and frontotemporal dementia are extremely rare. We report a large family with a...
CHCHD10 FTD-ALS mitochondrial DNA instability mitochondrial disorder Age of Onset Aged Alleles Amyotrophic Lateral Sclerosis DNA Mitochondrial Exome Female frontotemporal dementia HeLa Cells Humans Male Middle Aged Mitochondria Mitochondrial Diseases Mitochondrial Proteins Mutation Missense Pedigree Phenotype
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer.
Gouji Toyokawa, Ken Masuda, Yataro Daigo, Hyun-Soo Cho, Masanori Yoshimatsu, Masashi Takawa, Shinya Hayami, Kazuhiro Maejima, Makoto Chino, Helen I Field, David E Neal, Eiju Tsuchiya, Bruce AJ Ponder, Yoshihiko Maehara, Yusuke Nakamura, Ryuji Hamamoto
Jun 28, 2011
Biomarkers Tumor Carcinoma Non-Small-Cell Lung Cell Cycle Proteins Cell Line Tumor Cell Proliferation DNA-Binding Proteins Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Silencing HCT116 Cells HEK293 Cells HeLa Cells Hep G2 Cells Humans Lung Neoplasms Minichromosome Maintenance Complex Component 7 Neoplasms Nuclear Proteins Prognosis Protein Binding Protein-Arginine N-Methyltransferases RNA Small Interfering
KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.
Yan Zi Au, Muxin Gu, Etienne De Braekeleer, Malgorzata Gozdecka, Demetrios Aspris, Yusuke Tarumoto, Jonathan Cooper, Jason Yu, Swee Hoe Ong, Xi Chen, Konstantinos Tzelepis, Brian JP Huntly, George Vassiliou, Kosuke Yusa
Aug 14, 2020
Histone acetyltransferases (HATs) catalyze the transfer of an acetyl group from acetyl-CoA to lysine residues of histones and play a central role in transcriptional regulation in diverse biological processes. Dysregulation of...
Apoptosis Biomarkers Tumor Cell Differentiation Cell Line Tumor Disease Management Epigenesis Genetic Gene Knockout Techniques Gene Rearrangement Genetic Association Studies Genetic Predisposition to Disease Histone Acetyltransferases Histone-Lysine N-Methyltransferase Histones Humans Leukemia Myeloid Acute Myeloid Cells Myeloid-Lymphoid Leukemia Protein Oncogene Proteins Fusion Promoter Regions Genetic Protein Binding
Low Contact Barrier in 2H/1T' MoTe2 In-Plane Heterostructure Synthesized by Chemical Vapor Deposition.
Xiang Zhang, Zehua Jin, Luqing Wang, Jordan A Hachtel, Eduardo Villarreal, Zixing Wang, Teresa Ha, Yusuke Nakanishi, Chandra Sekhar Tiwary, Jiawei Lai, Liangliang Dong, Jihui Yang, Robert Vajtai, Emilie Ringe, Juan Carlos Idrobo, Boris I Yakobson, Jun Lou, Vincent Gambin, Rachel Koltun, Pulickel M Ajayan
Apr 12, 2019
Metal-semiconductor contact has been a critical topic in the semiconductor industry because it influences device performance remarkably. Conventional metals have served as the major contact material in electronic and...
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