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Animal Models for Target Diseases in Gene Therapy - using DNA and siRNA Delivery Strategies
Nanoparticles, including lipopolyamines leading to lipoplexes, liposomes, and polyplexes are targeted drug carrier systems in the current search for a successful delivery system for polynucleic acids. This review is focused on...
Animal Models for Target Diseases in Gene Therapy - using DNA and siRNA Delivery Strategies
Nanoparticles, including lipopolyamines leading to lipoplexes, liposomes, and polyplexes are targeted drug carrier systems in the current search for a successful delivery system for polynucleic acids. This review is focused on...
Investigating the Effect of the wee-1.3 and pam-1 Mutations on Meiosis in C. elegans
PAM-1 is a puromycin sensitive aminopeptidase responsible for cleaving the amino acid from the N-terminus of unknown target proteins. In our model system, a microscopic nematode known as C. elegans, functional PAM-1 is required...
Published by: Ursinus College
EEG evidence that morally relevant autobiographical memories can be suppressed.
Remembering unpleasant events can trigger negative feelings. Fortunately, research indicates that unwanted retrieval can be suppressed to prevent memories from intruding into awareness, improving our mental state. The current...
Goal-directed mechanisms that constrain retrieval predict subsequent memory for new "foil" information.
Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease
Ilaria Canobbio, Caterina Visconte, Barbara Oliviero, Gianni Guidetti, Marta Zara, Giordano Pula, Mauro Torti
Dec 01, 2016
Vascular dysfunctions and Alzheimer's disease show significant similarities and overlaps. Cardiovascular risk factors (hypercholesterolemia, hypertension, obesity, atherosclerosis and diabetes) increase the risk of vascular...
Increased platelet adhesion and thrombus formation in a mouse model of Alzheimer's disease
Ilaria Canobbio, Caterina Visconte, Barbara Oliviero, Gianni Guidetti, Marta Zara, Giordano Pula, Mauro Torti
Dec 01, 2016
Vascular dysfunctions and Alzheimer's disease show significant similarities and overlaps. Cardiovascular risk factors (hypercholesterolemia, hypertension, obesity, atherosclerosis and diabetes) increase the risk of vascular...
Alpha Oscillations during Incidental Encoding Predict Subsequent Memory for New "Foil" Information.
People can employ adaptive strategies to increase the likelihood that previously encoded information will be successfully retrieved. One such strategy is to constrain retrieval toward relevant information by reimplementing the...
Arbuscular mycorrhizal fungal community composition is altered by long-term litter removal but not litter addition in a lowland tropical forest
M Sheldrake, NP Rosenstock, D Revillini, PA Olsson, S Mangan, EJ Sayer, H Wallander, BL Turner, EVJ Tanner
Feb 09, 2017
Screening for Highly Transduced Genes in Staphylococcus aureus Revealed Both Lateral and Specialized Transduction.
Janine Zara Bowring, Yue Su, Ahlam Alsaadi, Sine L Svenningsen, Julian Parkhill, Hanne Ingmer
Mar 13, 2022
Bacteriophage-mediated transduction of bacterial DNA is a major route of horizontal gene transfer in the human pathogen, Staphylococcus aureus. Transduction involves the packaging of bacterial DNA by viruses and enables the...
COVID-19 lockdown highlights impact of recreational activities on the behaviour of coral reef fishes
William E. Feeney, Zara-Louise Cowan, Frédéric Bertucci, Rohan M. Brooker, Gilles Siu, Frédérique Jossinet, Tamatoa Bambridge, René Galzin, David Lecchini
Apr 17, 2023
Published by: The Royal Society
COVID-19 lockdown highlights impact of recreational activities on the behaviour of coral reef fishes
William E. Feeney, Zara-Louise Cowan, Frédéric Bertucci, Rohan M. Brooker, Gilles Siu, Frédérique Jossinet, Tamatoa Bambridge, René Galzin, David Lecchini
Dec 08, 2022
Published by: The Royal Society
Receptor-ligand supplementation via a self-cleaving 2A peptide-based gene therapy promotes CNS axonal transport with functional recovery.
Tasneem Z Khatib, Andrew Osborne, Sujeong Yang, Zara Ali, Wanyi Jia, Ilya Manyakin, Katie Hall, Robert Watt, Peter S Widdowson, Keith R Martin
Jul 05, 2021
Gene replacement approaches are leading to a revolution in the treatment of previously debilitating monogenic neurological conditions. However, the application of gene therapy to complex polygenic conditions has been limited....
Domestication via the commensal pathway in a fish-invertebrate mutualism
Rohan M. Brooker, Jordan M. Casey, Zara-Louise Cowan, Tiffany L. Sih, Danielle L. Dixson, Andrea Manica, William E. Feeney
Dec 07, 2020
Abstract: Domesticator-domesticate relationships are specialized mutualisms where one species provides multigenerational support to another in exchange for a resource or service, and through which both partners gain an advantage...
Plant responses to fertilization experiments in lowland, species-rich, tropical forests.
S Joseph Wright, Benjamin L Turner, Joseph B Yavitt, Kyle E Harms, Michael Kaspari, Edmund VJ Tanner, Jelena Bujan, Eric A Griffin, Jordan R Mayor, Sarah C Pasquini, Merlin Sheldrake, Milton N Garcia
Nov 01, 2018
We present a meta-analysis of plant responses to fertilization experiments conducted in lowland, species-rich, tropical forests. We also update a key result and present the first species-level analyses of tree growth rates for a...
Domestication via the commensal pathway in a fish-invertebrate mutualism.
Rohan M Brooker, Jordan M Casey, Zara-Louise Cowan, Tiffany L Sih, Danielle L Dixson, Andrea Manica, William E Feeney
Feb 01, 2021
Domesticator-domesticate relationships are specialized mutualisms where one species provides multigenerational support to another in exchange for a resource or service, and through which both partners gain an advantage over...
Muscle Research and Gene Ontology
Erika Feltrin, Stefano Campanaro, Alexander D Diehl, Elisabeth Ehler, Georgine Faulkner, Jennifer Fordham, Chiara Gardin, Midori Harris, David Hill, Ralph Knoell, Paolo Laveder, Lorenza Mittempergher, Alessandra Nori, Carlo Reggiani, Vincenzo Sorrentino, Pompeo Volpe, Ivano Zara, Giorgio Valle, Jennifer Deegan
Nov 29, 2018
BACKGROUND: The Gene Ontology Project provides structured controlled vocabularies for molecular biology that can be used for the functional annotation of genes and gene products. In a collaboration between the Gene Ontology (GO)...
Peptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice.
Sam G Galvin, Pierre Larraufie, Richard G Kay, Haidee Pitt, Elise Bernard, Anne K McGavigan, Helen Brant, John Hood, Laura Sheldrake, Shannon Conder, Dawn Atherton-Kemp, Van B Lu, Elisabeth AA O'Flaherty, Geoffrey P Roberts, Carina Ämmälä, Lutz Jermutus, David Baker, Fiona M Gribble, Frank Reimann
Mar 18, 2021
The Digital Banal
Gill Moore
May 07, 2019
Lamenting the perceived tendency of media theorists to lapse into “speculations about the [digital] future, rather than a record or theory of the present”, Lev Manovich once imagined a historian asking, years from now: “Where...
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