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SGK1 mutations in DLBCL generate hyperstable protein neoisoforms that promote AKT independence.
Jie Gao, Eirini Sidiropoulou, Ieuan Walker, Joanna A Krupka, Karol Mizielinski, Zelvera Usheva, Shamith A Samarajiwa, Daniel J Hodson
May 21, 2021
Serum and glucocorticoid-regulated kinase 1 (SGK1) is one of the most frequently mutated genes in diffuse large B-cell lymphoma (DLBCL). However, little is known about its function or the consequence of its mutation. The...
Genetic modification of primary human B cells to model high-grade lymphoma
Rebecca Caeser, Miriam Di Re, Joanna A. Krupka, Jie Gao, Maribel Lara-Chica, João M. L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F. P. Runge, Philip A. Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J. P. Huntly, Annalisa Mupo, Rachael J. M. Bashford-Rogers, Daniel J. Hodson
Apr 07, 2021
Abstract: Sequencing studies of diffuse large B cell lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis...
Genetic modification of primary human B cells to model high-grade lymphoma.
Rebecca Caeser, Miriam Di Re, Joanna A Krupka, Jie Gao, Maribel Lara-Chica, João ML Dias, Susanna L Cooke, Rachel Fenner, Zelvera Usheva, Hendrik FP Runge, Philip A Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S Vassiliou, Brian JP Huntly, Annalisa Mupo, Rachael JM Bashford-Rogers, Daniel J Hodson
Sep 13, 2019
Animals B-Lymphocytes CRISPR-Cas Systems Cell Line Tumor Cell Proliferation Coculture Techniques Genetic Vectors Germinal Center High-Throughput Screening Assays Humans Lymphoma Large B-Cell Diffuse Mice Neoplasm Grading Primary Cell Culture Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-bcl-6 Proto-Oncogene Proteins c-myc Retroviridae Transduction Genetic Xenograft Model Antitumor Assays
Genetic modification of primary human B cells to model high-grade lymphoma
Rebecca Caeser, Miriam Di Re, Joanna A. Krupka, Jie Gao, Maribel Lara-Chica, João M. L. Dias, Susanna L. Cooke, Rachel Fenner, Zelvera Usheva, Hendrik F. P. Runge, Philip A. Beer, Hesham Eldaly, Hyo-Kyung Pak, Chan-Sik Park, George S. Vassiliou, Brian J. P. Huntly, Annalisa Mupo, Rachael J. M. Bashford-Rogers, Daniel J. Hodson
Oct 03, 2020
Abstract: Sequencing studies of diffuse large B cell lymphoma (DLBCL) have identified hundreds of recurrently altered genes. However, it remains largely unknown whether and how these mutations may contribute to lymphomagenesis...
Early-Onset Osteoarthritis originates at the chondrocyte level in Hip Dysplasia.
Paula A Hernandez, Joel Wells, Emiliya Usheva, Paul A Nakonezny, Zahra Barati, Roberto Gonzalez, Layla Kassem, Frances M D Henson
Feb 19, 2020
Subjects with developmental dysplasia of the hip (DDH) often show early-onset osteoarthritis (OA); however, the molecular mechanisms underlying this pathology are not known. We investigated whether cellular changes in...
Published by: Scientific reports
Early-Onset Osteoarthritis originates at the chondrocyte level in Hip Dysplasia.
Paula A Hernandez, Joel Wells, Emiliya Usheva, Paul A Nakonezny, Zahra Barati, Roberto Gonzalez, Layla Kassem, Frances MD Henson
Jan 16, 2021
Subjects with developmental dysplasia of the hip (DDH) often show early-onset osteoarthritis (OA); however, the molecular mechanisms underlying this pathology are not known. We investigated whether cellular changes in...
Sequential inverse dysregulation of the RNA helicases DDX3X and DDX3Y facilitates MYC-driven lymphomagenesis.
Chun Gong, Joanna A Krupka, Jie Gao, Nicholas F Grigoropoulos, George Giotopoulos, Ryan Asby, Michael Screen, Zelvera Usheva, Francesco Cucco, Sharon Barrans, Daniel Painter, Nurmahirah Binte Mohammed Zaini, Björn Haupl, Susanne Bornelöv, Igor Ruiz De Los Mozos, Wei Meng, Peixun Zhou, Alex E Blain, Sorcha Forde, Jamie Matthews, Michelle Guet Khim Tan, GA Amos Burke, Siu Kwan Sze, Philip Beer, Cathy Burton, Peter Campbell, Vikki Rand, Suzanne D Turner, Jernej Ule, Eve Roman, Reuben Tooze, Thomas Oellerich, Brian J Huntly, Martin Turner, Ming-Qing Du, Shamith A Samarajiwa, Daniel J Hodson
Jul 30, 2021
DDX3X is a ubiquitously expressed RNA helicase involved in multiple stages of RNA biogenesis. DDX3X is frequently mutated in Burkitt lymphoma, but the functional basis for this is unknown. Here, we show that loss-of-function...
Burkitt lymphoma DDX3X Myc RNA helicase Germinal Center proteotoxic stress Translation Adolescent Adult Aged Aged 80 and over Animals B-Lymphocytes Cell Line Tumor Child Child Preschool DEAD-box RNA Helicases Endoplasmic reticulum stress Female Gene Expression Regulation Enzymologic Gene Expression Regulation Neoplastic Humans Loss of Function Mutation Lymphoma B-Cell Male Mice Transgenic Middle Aged Minor Histocompatibility Antigens Neoplasm Proteins Protein Biosynthesis Proteome Proteostasis Proto-Oncogene Proteins c-myc Young Adult