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Results: 88
Using genetic variation to disentangle the complex relationship between food intake and health outcomes.
Nicola Pirastu, Ciara McDonnell, Eryk J Grzeszkowiak, Ninon Mounier, Fumiaki Imamura, Jordi Merino, Felix Day, Jie Zheng, Nele Taba, Maria Pina Concas, Linda Repetto, Katherine Kentistou, Antonietta Robino, Tõnu Esko, Peter K Joshi, Krista Fischer, Kenneth Ong, Tom R Gaunt, Zoltán Kutalik, John RB Perry, James F Wilson
Jun 07, 2022
Diet is considered as one of the most important modifiable factors influencing human health, but efforts to identify foods or dietary patterns associated with health outcomes often suffer from biases, confounding, and reverse...
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.
Katherine A Kentistou, Jian'an Luan, Laura BL Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton
Feb 19, 2023
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full genetic...
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene.
Katherine A Kentistou, Jian'an Luan, Laura BL Wittemans, Catherine Hambly, Lucija Klaric, Zoltán Kutalik, John R Speakman, Nicholas J Wareham, Timothy J Kendall, Claudia Langenberg, James F Wilson, Peter K Joshi, Nicholas M Morton
Jan 19, 2023
Obesity remains an unmet global health burden. Detrimental anatomical distribution of body fat is a major driver of obesity-mediated mortality risk and is demonstrably heritable. However, our understanding of the full genetic...
Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors.
Using genetic variation to disentangle the complex relationship between food intake and health outcomes.
Nicola Pirastu, Ciara McDonnell, Eryk J Grzeszkowiak, Ninon Mounier, Fumiaki Imamura, Jordi Merino, Felix R Day, Jie Zheng, Nele Taba, Maria Pina Concas, Linda Repetto, Katherine A Kentistou, Antonietta Robino, Tõnu Esko, Peter K Joshi, Krista Fischer, Ken K Ong, Tom R Gaunt, Zoltán Kutalik, John RB Perry, James F Wilson
Jul 03, 2022
Diet is considered as one of the most important modifiable factors influencing human health, but efforts to identify foods or dietary patterns associated with health outcomes often suffer from biases, confounding, and reverse...
Leading exponential finite size corrections for non-diagonal form factors
Abstract
We derive the leading exponential finite volume corrections in two dimensional integrable models for non-diagonal form factors in diagonally...
Shedding light on the HTA consultancy market
Marcell Csanádi, Piotr Ozierański, Olga Löblová, Lawrence King, Zoltán Kaló, Lajos Botz
Sep 13, 2019
Research on health technology assessment (HTA) from a policy perspective typically examines public HTA bodies, with little attention devoted to how manufacturers develop their evidence submissions. Taking Poland as a crucial...
Alternative access schemes for pharmaceuticals in Europe
Olga Löblová, Marcell Csanádi, Piotr Ozierański, Zoltán Kaló, Lawrence King, Martin McKee
Jul 01, 2019
European governments employ sophisticated health technology assessment and regulatory procedures to identify which pharmaceuticals to fund publicly. However, there are persisting demands from patients for those drugs excluded...
Alternative access schemes for pharmaceuticals in Europe
Olga Löblová, Marcell Csanádi, Piotr Ozierański, Zoltán Kaló, Lawrence King, Martin McKee
Jul 01, 2019
European governments employ sophisticated health technology assessment and regulatory procedures to identify which pharmaceuticals to fund publicly. However, there are persisting demands from patients for those drugs excluded...
Across-cohort QC analyses of GWAS summary statistics from complex traits.
Guo-Bo Chen, Sang Hong Lee, Matthew R Robinson, Maciej Trzaskowski, Zhi-Xiang Zhu, Thomas W Winkler, Felix R Day, Damien C Croteau-Chonka, Andrew R Wood, Adam E Locke, Zoltán Kutalik, Ruth JF Loos, Timothy M Frayling, Joel N Hirschhorn, Jian Yang, Naomi R Wray, Genetic Investigation of Anthropometric Traits (GIANT) Consortium, Peter M Visscher
Sep 05, 2018
Genome-wide association studies (GWASs) have been successful in discovering SNP trait associations for many quantitative traits and common diseases. Typically, the effect sizes of SNP alleles are very small and this requires...
Alternative access schemes for pharmaceuticals in Europe
Olga Löblová, Marcell Csanádi, Piotr Ozierański, Zoltán Kaló, Lawrence King, Martin McKee
Aug 21, 2019
European governments employ sophisticated health technology assessment and regulatory procedures to identify which pharmaceuticals to fund publicly. However, there are persisting demands from patients for those drugs excluded...
Developmental and tissue specific changes of ubiquitin forms in Drosophila melanogaster.
In most Eukaryotes, ubiquitin either exists as free monoubiquitin or as a molecule that is covalently linked to other proteins. These two forms cycle between each other and due to the concerted antagonistic activity of...
Patterns of alternative access
Olga Löblová, Marcell Csanádi, Piotr Ozierański, Zoltán Kaló, Lawrence King, Martin McKee
Aug 21, 2019
Many countries employ "alternative access schemes" (e.g. compassionate use, early access programs, off-label use) that seek to provide patients with access to drugs not included on a positive drug list. These schemes offer...
Shedding light on the HTA consultancy market
Marcell Csanádi, Piotr Ozierański, Olga Löblová, Lawrence King, Zoltán Kaló, Lajos Botz
Dec 01, 2019
Research on health technology assessment (HTA) from a policy perspective typically examines public HTA bodies, with little attention devoted to how manufacturers develop their evidence submissions. Taking Poland as a crucial...
Transparency in practice
Piotr Ozierański, Olga Löblová, Natalia Nicholls, Marcell Csanádi, Zoltán Kaló, Martin McKee, Lawrence King
Feb 13, 2018
Transparency is recognised to be a key underpinning of the work of health technology assessment (HTA) agencies, yet it has only recently become a subject of systematic inquiry. We contribute to this research field by considering...
Patterns of alternative access
Olga Löblová, Marcell Csanádi, Piotr Ozierański, Zoltán Kaló, Lawrence King, Martin McKee
Aug 31, 2019
Many countries employ "alternative access schemes" (e.g. compassionate use, early access programs, off-label use) that seek to provide patients with access to drugs not included on a positive drug list. These schemes offer...
Shedding light on the HTA consultancy market
Marcell Csanádi, Piotr Ozierański, Olga Löblová, Lawrence King, Zoltán Kaló, Lajos Botz
Dec 01, 2019
Research on health technology assessment (HTA) from a policy perspective typically examines public HTA bodies, with little attention devoted to how manufacturers develop their evidence submissions. Taking Poland as a crucial...
Patterns of alternative access
Olga Löblová, Marcell Csanádi, Piotr Ozierański, Zoltán Kaló, Lawrence King, Martin McKee
Aug 31, 2019
Many countries employ "alternative access schemes" (e.g. compassionate use, early access programs, off-label use) that seek to provide patients with access to drugs not included on a positive drug list. These schemes offer...
Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria.
Zoltán Bánki, Lisa Seekircher, Barbara Falkensammer, David Bante, Helena Schäfer, Teresa Harthaller, Janine Kimpel, Peter Willeit, Dorothee von Laer, Wegene Borena
Sep 26, 2022
In response to a large outbreak of the SARS-CoV-2 Beta (B.1.351) variant in the district Schwaz, Austria, a rapid mass vaccination campaign with BNT162b2 was carried out in spring 2021, immunizing more than 70% of the adult...
Six-Month Follow-Up of Immune Responses after a Rapid Mass Vaccination against SARS-CoV-2 with BNT162b2 in the District of Schwaz/Austria.
Zoltán Bánki, Lisa Seekircher, Barbara Falkensammer, David Bante, Helena Schäfer, Teresa Harthaller, Janine Kimpel, Peter Willeit, Dorothee von Laer, Wegene Borena
Jul 28, 2022
In response to a large outbreak of the SARS-CoV-2 Beta (B.1.351) variant in the district Schwaz, Austria, a rapid mass vaccination campaign with BNT162b2 was carried out in spring 2021, immunizing more than 70% of the adult...
The ortho effect in directed C-H activation.
Balázs L Tóth, Anna Monory, Orsolya Egyed, Attila Domján, Attila Bényei, Bálint Szathury, Zoltán Novák, András Stirling
Jul 28, 2021
The success of transition metal-catalysed ortho-directed C-H activation is often plagued by the effects of undesirable interactions between the directing group (DG) and other groups introduced into the aromatic core of the...
LYS12 LysM receptor decelerates Phytophthora palmivora disease progression in Lotus japonicus.
Winnie Fuechtbauer, Temur Yunusov, Zoltán Bozsóki, Aleksandr Gavrin, Euan K James, Jens Stougaard, Sebastian Schornack, Simona Radutoiu
Jan 30, 2018
Phytophthora palmivora is a devastating oomycete plant pathogen. We found that P. palmivora induces disease in Lotus japonicus and used this interaction to identify cellular and molecular events in response to this oomycete...
MADGAN
Changhee Han, Leonardo Rundo, Kohei Murao, Tomoyuki Noguchi, Yuki Shimahara, Zoltán Ádám Milacski, Saori Koshino, Evis Sala, Hideki Nakayama, Shin’ichi Satoh
Apr 26, 2021
Abstract: Background: Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical...
Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs.
Lisa Hurler, Erik JM Toonen, Erika Kajdácsi, Bregje van Bree, Ricardo JMGE Brandwijk, Wieke de Bruin, Paul A Lyons, Laura Bergamaschi, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, György Sinkovits, László Cervenak, Reinhard Würzner, Zoltán Prohászka
Dec 24, 2022
The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and...
C1-INH complexes C1s/C1-INH complex MASP-1/C1-INH complex assay development and validation classical pathway activation early complement activation lectin pathway activation Adult Humans Complement C1 Inhibitor Protein Complement System Proteins covid-19 Lectins Mannose-Binding Protein-Associated Serine Proteases Enzyme-Linked Immunosorbent Assay
MADGAN
Changhee Han, Leonardo Rundo, Kohei Murao, Tomoyuki Noguchi, Yuki Shimahara, Zoltán Ádám Milacski, Saori Koshino, Evis Sala, Hideki Nakayama, Shin'ichi Satoh
Jul 12, 2021
BACKGROUND: Unsupervised learning can discover various unseen abnormalities, relying on large-scale unannotated medical images of healthy subjects. Towards this, unsupervised methods reconstruct a 2D/3D single medical image to...
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