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Results: 101
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Ros Eeles, Zsofia Kote-Jarai, Paul D P Pharoah, Nora Pashayan
Jan 27, 2020
BACKGROUND:The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69. Knowing how the potential benefits and harms of screening...
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Zsofia Kote-Jarai, Paul DP Pharoah, Nora Pashayan
Feb 07, 2020
BACKGROUND: The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69. Knowing how the potential benefits and harms of...
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Zsofia Kote-Jarai, Paul D. P. Pharoah, Nora Pashayan
Dec 20, 2019
Background: The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55–69. Knowing how the potential benefits and harms of...
Abelian sandpiles
Antal A Jarai
Jan 01, 0001
We review the Majumdar-Dhar bijection between recurrent states of the Abelian sandpile model and spanning trees. We generalize earlier results of Athreya and Jarai on the infinite volume limit of the stationary distribution of...
Abelian sandpiles
Antal A Jarai
Jan 01, 0001
We review the Majumdar-Dhar bijection between recurrent states of the Abelian sandpile model and spanning trees. We generalize earlier results of Athreya and Jarai on the infinite volume limit of the stationary distribution of...
Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.
Chey Loveday, Kevin Litchfield, Max Levy, Amy Holroyd, Peter Broderick, Zsofia Kote-Jarai, Alison M Dunning, Kenneth Muir, Julian Peto, Rosalind Eeles, Douglas F Easton, Darshna Dudakia, Nick Orr, Nora Pashayan, Alison Reid, Robert A Huddart, Richard S Houlston, Clare Turnbull
Feb 23, 2018
Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number of loci...
Homeobox B13 G84E Mutation and Prostate Cancer Risk.
Tommy Nyberg, Koveela Govindasami, Goska Leslie, Tokhir Dadaev, Elizabeth Bancroft, Holly Ni Raghallaigh, Mark N Brook, Nafisa Hussain, Diana Keating, Andrew Lee, Romayne McMahon, Angela Morgan, Andrea Mullen, Andrea Osborne, Reshma Rageevakumar, UK Genetic Prostate Cancer Study Collaborators, Zsofia Kote-Jarai, Rosalind Eeles, Antonis C Antoniou
Dec 19, 2018
BACKGROUND: The homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutation is uncertain. OBJECTIVE: To obtain...
Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis.
Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology.
Chey Loveday, Philip Law, Kevin Litchfield, Max Levy, Amy Holroyd, Peter Broderick, Zsofia Kote-Jarai, Alison M Dunning, Kenneth Muir, Julian Peto, Rosalind Eeles, Douglas F Easton, Darshna Dudakia, Nick Orr, Nora Pashayan, The PRACTICAL Consortium UK Testicular Cancer Collaboration, Alison Reid, Robert A Huddart, Richard S Houlston, Clare Turnbull
Sep 21, 2018
UNLABELLED: Testicular germ cell tumour (TGCT) is the most common cancer in young men. Multiplex TGCT families have been well reported and analyses of population cancer registries have demonstrated a four- to eightfold risk to...
Familial GWAS Genetics polygenic risk score Testicular germ cell tumour Biomarkers Tumor Case-Control Studies Environment Genetic Predisposition to Disease Genome-Wide Association Study Heredity Humans Life Style Male Multifactorial Inheritance Neoplasms Germ Cell and Embryonal Pedigree Phenotype Polymorphism Single Nucleotide Risk Assessment Risk Factors Testicular Neoplasms
Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk.
Robert J Macinnis, Daniel F Schmidt, Enes Makalic, Gianluca Severi, Liesel M Fitzgerald, Matthias Reumann, Miroslaw K Kapuscinski, Adam Kowalczyk, Zeyu Zhou, Benjamin Goudey, Guoqi Qian, Quang M Bui, Daniel J Park, Adam Freeman, Melissa C Southey, Ali Amin Al Olama, Zsofia Kote-Jarai, Rosalind A Eeles, John L Hopper, Graham G Giles, UK Genetic Prostate Cancer Study Collaborators
Oct 07, 2016
Comprehensive functional annotation of 77 prostate cancer risk loci.
Dennis J Hazelett, Suhn Kyong Rhie, Malaina Gaddis, Chunli Yan, Daniel L Lakeland, Simon G Coetzee, Ellipse/GAME-ON consortium, PRACTICAL Consortium, Brian E Henderson, Houtan Noushmehr, Wendy Cozen, Zsofia Kote-Jarai, Rosalind A Eeles, Douglas F Easton, Christopher A Haiman, Wange Lu, Peggy J Farnham, Gerhard A Coetzee
Sep 08, 2018
Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and onset/progression of disease processes remain to be identified. Here we report the...
Alleles Chromatin Enhancer Elements Genetic Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Genome-Wide Association Study Humans Linkage Disequilibrium Male Molecular Sequence Annotation Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Prostatic Neoplasms Response Elements Risk Factors Transcription Factors
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Amit Sud, Hauke Thomsen, Giulia Orlando, Asta Försti, Philip J Law, Peter Broderick, Rosie Cooke, Fadi Hariri, Tomi Pastinen, Douglas F Easton, Paul DP Pharoah, Alison M Dunning, Julian Peto, Federico Canzian, Rosalind Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Daniele Campa, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Elke Pogge von Strandmann, Anthony J Swerdlow, Andreas Engert, Nick Orr, Kari Hemminki, Richard S Houlston
Nov 21, 2018
The BARCODE1 Pilot
Sarah Benafif, Holly Ni Raghallaigh, Eva McGrowder, Edward J Saunders, Mark N Brook, Sibel Saya, Reshma Rageevakumar, Sarah Wakerell, Denzil James, Anthony Chamberlain, Natalie Taylor, Matthew Hogben, Barbara Benton, Lucia D'Mello, Kathryn Myhill, Christos Mikropoulos, Hywel Bowen-Perkins, Imran Rafi, Michelle Ferris, Andre Beattie, Shophia Kuganolipava, Tamsin Sevenoaks, Juliet Bower, Pardeep Kumar, Steven Hazell, Nandita M deSouza, Antonis Antoniou, Elizabeth Bancroft, Zsofia Kote-Jarai, Rosalind Eeles
Jul 21, 2021
OBJECTIVES: To assess the feasibility and uptake of a community-based prostate cancer (PCa) screening programme selecting men according to their genetic risk of PCa. To assess the uptake of PCa screening investigations by men...
Height, selected genetic markers and prostate cancer risk
Artitaya Lophatananon, Sarah Stewart-Brown, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Liesel M Fitzgerald, Melissa C Southey, Paul Pharoah, Nora Pashayan, Henrik Gronberg, Fredrik Wiklund, Markus Aly, Janet L Stanford, Hermann Brenner, Aida K Dieffenbach, Volker Arndt, Jong Y Park, Hui-Yi Lin, Thomas Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Amanda Spurdle, Judith A Clements, APCB BioResource, PRACTICAL Consortium, Douglas Easton, Rosalind A Eeles, Kenneth Muir
Dec 07, 2018
This corrects the article DOI: 10.1038/bjc.2017.231.
Polyunsaturated fatty acids and prostate cancer risk
Nikhil K Khankari, Harvey J Murff, Chenjie Zeng, Wanqing Wen, Rosalind A Eeles, Douglas F Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Jenny L Donovan, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Wei Zheng, PRACTICAL Consortium
Dec 01, 2017
BACKGROUND: Prostate cancer is a common cancer worldwide with no established modifiable lifestyle factors to guide prevention. The associations between polyunsaturated fatty acids (PUFAs) and prostate cancer risk have been...
Height, selected genetic markers and prostate cancer risk
Artitaya Lophatananon, Sarah Stewart-Brown, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch Garcia, David E Neal, Freddie C Hamdy, Jenny L Donovan, Graham G Giles, Liesel M Fitzgerald, Melissa C Southey, Paul Pharoah, Nora Pashayan, Henrik Gronberg, Fredrik Wiklund, Markus Aly, Janet L Stanford, Hermann Brenner, Aida K Dieffenbach, Volker Arndt, Jong Y Park, Hui-Yi Lin, Thomas Sellers, Chavdar Slavov, Radka Kaneva, Vanio Mitev, Jyotsna Batra, Amanda Spurdle, Judith A Clements, APCB BioResource, PRACTICAL Consortium, Douglas Easton, Rosalind A Eeles, Kenneth Muir
Dec 08, 2017
BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed data...
Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer.
Burcu F Darst, Tokhir Dadaev, Ed Saunders, Xin Sheng, Peggy Wan, Loreall Pooler, Lucy Y Xia, Stephen Chanock, Sonja I Berndt, Susan M Gapstur, Victoria Stevens, Demetrius Albanes, Stephanie J Weinstein, Vincent Gnanapragasam, Graham G Giles, Tu Nguyen-Dumont, Roger L Milne, Mark Pomerantz, Julie A Schmidt, Lorelei Mucci, William J Catalona, Kurt N Hetrick, Kimberly F Doheny, Robert J Macinnis, Melissa C Southey, Rosalind A Eeles, Fredrik Wiklund, Zsofia Kote-Jarai, David V Conti, Christopher A Haiman
Sep 03, 2020
The BARCODE1 Pilot
Sarah Benafif, Holly Ni Raghallaigh, Eva McGrowder, Edward J. Saunders, Mark N. Brook, Sibel Saya, Reshma Rageevakumar, Sarah Wakerell, Denzil James, Anthony Chamberlain, Natalie Taylor, Matthew Hogben, Barbara Benton, Lucia D’Mello, Kathryn Myhill, Christos Mikropoulos, Hywel Bowen‐Perkins, Imran Rafi, Michelle Ferris, Andre Beattie, Shophia Kuganolipava, Tamsin Sevenoaks, Juliet Bower, Pardeep Kumar, Steven Hazell, Nandita M. deSouza, Antonis Antoniou, Elizabeth Bancroft, Zsofia Kote‐Jarai, Rosalind Eeles
Aug 16, 2021
Published by: BJU International
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.
Lang Wu, Yaohua Yang, Xingyi Guo, Xiao-Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Ran Tao, Chong Wu, Jason B Nikas, Yanfa Sun, Jingjing Zhu, Monique J Roobol, Graham G Giles, Hermann Brenner, Esther M John, Judith Clements, Eli Marie Grindedal, Jong Y Park, Janet L Stanford, Zsofia Kote-Jarai, Christopher A Haiman, Rosalind A Eeles, Wei Zheng, Jirong Long, PRACTICAL Consortium, CRUK Consortium, BPC3 Consortium, CAPS Consortium, PEGASUS Consortium
Aug 11, 2021
It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence...
Alcohol consumption and prostate cancer incidence and progression
Clair Brunner, Neil M Davies, Richard M Martin, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Jenny Donovan, Freddie C Hamdy, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, PRACTICAL Consortium, Luisa Zuccolo
Sep 22, 2016
Mendelian randomisation Alcohol alcohol metabolising genes prostate cancer Aged Aged 80 and over Alcohol Drinking Aldehyde Dehydrogenase Aldehyde Dehydrogenase 1 Family Aldehyde Dehydrogenase Mitochondrial Case-Control Studies Disease Progression Humans Incidence Linkage Disequilibrium Male Middle Aged Neoplasm Grading Polymorphism Single Nucleotide Prostatic Neoplasms Regression Analysis Retinal Dehydrogenase Survival Analysis
Phase transition in a sequential assignment problem on graphs
Antal A. Jarai
Aug 31, 2017
We study the following sequential assignment problem on a finite graph G = (V ,E). Each edge e ∈ E starts with an integer value n e ≥ 0, and we write n =∑ e∈En e. At time t, 1 ≤ t ≤ n, a...
Critical phenomenon Discrete stochastic optimal control Markov decision process Phase Transition Stochastic Dynamic Programming Stochastic sequential assignment /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty
Phase transition in a sequential assignment problem on graphs
Antal A. Jarai
Aug 31, 2017
We study the following sequential assignment problem on a finite graph G = (V ,E). Each edge e ∈ E starts with an integer value n e ≥ 0, and we write n =∑ e∈En e. At time t, 1 ≤ t ≤ n, a...
Critical phenomenon Discrete stochastic optimal control Markov decision process Phase Transition Stochastic Dynamic Programming Stochastic sequential assignment /dk/atira/pure/subjectarea/asjc/2600/2613 name=Statistics and Probability /dk/atira/pure/subjectarea/asjc/1800/1804 name=Statistics, Probability and Uncertainty
Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia.
Jayaram Vijayakrishnan, James Studd, Peter Broderick, Ben Kinnersley, Amy Holroyd, Philip J Law, Rajiv Kumar, James M Allan, Christine J Harrison, Anthony V Moorman, Ajay Vora, Eve Roman, Sivaramakrishna Rachakonda, Sally E Kinsey, Eamonn Sheridan, Pamela D Thompson, Julie A Irving, Rolf Koehler, Per Hoffmann, Markus M Nöthen, Stefanie Heilmann-Heimbach, Karl-Heinz Jöckel, Douglas F Easton, Paul DP Pharaoh, Alison M Dunning, Julian Peto, Frederico Canzian, Anthony Swerdlow, Rosalind A Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Mel Greaves, Martin Zimmerman, Claus R Bartram, Martin Schrappe, Martin Stanulla, Kari Hemminki, Richard S Houlston, PRACTICAL Consortium
Jul 09, 2018
Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a...
AA9int
Hui-Yi Lin, Po-Yu Huang, Dung-Tsa Chen, Heng-Yuan Tung, Thomas A Sellers, Julio M Pow-Sang, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Freddie Hamdy, David E Neal, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Yong-Jie Lu, PRACTICAL Consortium, Jong Y Park
Sep 21, 2018
MOTIVATION: The use of single nucleotide polymorphism (SNP) interactions to predict complex diseases is getting more attention during the past decade, but related statistical methods are still immature. We previously proposed...
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