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Results: 90
KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1.
Julie Borgel, Marek Tyl, Karin Schiller, Zsofia Pusztai, Christopher M Dooley, Wen Deng, Carol Wooding, Richard J White, Tobias Warnecke, Heinrich Leonhardt, Elisabeth M Busch-Nentwich, Till Bartke
Jun 20, 2018
Functional genomic elements are marked by characteristic DNA and histone modification signatures. How combinatorial chromatin modification states are recognized by epigenetic reader proteins and how this is linked to their...
Animals Animals Genetically Modified Cell Line Chromobox Protein Homolog 5 Chromosomal Proteins Non-Histone CpG Islands Cricetinae DNA Methylation F-Box Proteins HEK293 Cells HeLa Cells Histones Humans Jumonji Domain-Containing Histone Demethylases Models Genetic Mutation Neoplasms Nucleosomes Protein Interaction Domains and Motifs Recombinant Fusion Proteins Two-Hybrid System Techniques Zebrafish Zinc Fingers
Relationship between atomic structure and excellent glass forming ability in Pd42.5Ni7.5Cu30P20 metallic glass
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf-Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Nov 15, 2022
To understand the relation of the glass-forming ability (GFA) to the local atomic configurations of a
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Glass-forming ability Icosahedral arrangement Partial structure Persistent homology analysis Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Detailed structural analysis of amorphous Pd<sub>40</sub>Cu<sub>40</sub>P<sub>20</sub>
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Mar 01, 2021
To clarify the relationship between the glass-forming ability (GFA) and local atomic structure of Pd-based metallic glasses, the structures of an amorphous Pd40Cu40P20 (PCP) were investigated...
Anomalous X-ray scattering Glass-forming ability Hyper-ordered structures metallic glasses neutron diffraction Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Detailed structural analysis of amorphous Pd<sub>40</sub>Cu<sub>40</sub>P<sub>20</sub>
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Mar 01, 2021
To clarify the relationship between the glass-forming ability (GFA) and local atomic structure of Pd-based metallic glasses, the structures of an amorphous Pd40Cu40P20 (PCP) were investigated...
Anomalous X-ray scattering Glass-forming ability Hyper-ordered structures metallic glasses neutron diffraction Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Re-examining the role of Drosophila Sas-4 in centrosome assembly using two-colour-3D-SIM FRAP.
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Ros Eeles, Zsofia Kote-Jarai, Paul D P Pharoah, Nora Pashayan
Jan 27, 2020
BACKGROUND:The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69. Knowing how the potential benefits and harms of screening...
Relationship between atomic structure and excellent glass forming ability in Pd42.5Ni7.5Cu30P20 metallic glass
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf-Christian Pilgrim, László Pusztai, Satoshi Hiroi, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Nov 15, 2022
To understand the relation of the glass-forming ability (GFA) to the local atomic configurations of a
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Pd42.5Ni7.5Cu30P20 (PNCP) metallic glass having the best GFA at present, the local structures were investigated...
Glass-forming ability Icosahedral arrangement Partial structure Persistent homology analysis Reverse Monte Carlo modeling /dk/atira/pure/subjectarea/asjc/2500/2504 name=Electronic, Optical and Magnetic Materials /dk/atira/pure/subjectarea/asjc/2500/2503 name=Ceramics and Composites /dk/atira/pure/subjectarea/asjc/3100/3104 name=Condensed Matter Physics /dk/atira/pure/subjectarea/asjc/2500/2505 name=Materials Chemistry
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Zsofia Kote-Jarai, Paul DP Pharoah, Nora Pashayan
Feb 07, 2020
BACKGROUND: The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55-69. Knowing how the potential benefits and harms of...
Polygenic risk-tailored screening for prostate cancer
Tom Callender, Mark Emberton, Steve Morris, Ros Eeles, Zsofia Kote-Jarai, Paul D. P. Pharoah, Nora Pashayan
Dec 20, 2019
Background: The United States Preventive Services Task Force supports individualised decision-making for prostate-specific antigen (PSA)-based screening in men aged 55–69. Knowing how the potential benefits and harms of...
Partial structure investigation of the traditional bulk metallic glass Pd40Ni40 P20
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Kenji Maruyama, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Aug 28, 2019
Local structures of Pd40Ni40P20 bulk metallic glass were investigated by combining anomalous x-ray scattering close to the Pd and Ni K absorption edges, x-ray diffraction, neutron diffraction, and reverse Monte Carlo...
Evidence that a positive feedback loop drives centrosome maturation in fly embryos.
Ines Alvarez-Rodrigo, Thomas L Steinacker, Saroj Saurya, Paul T Conduit, Janina Baumbach, Zsofia A Novak, Mustafa G Aydogan, Alan Wainman, Jordan W Raff
Oct 31, 2019
Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear...
D. melanogaster Spd-2 Cell Biology centriole Centrosome feedback loop pericentriolar material polo kinase Animals Centrosome Drosophila Proteins Drosophila melanogaster Embryo Nonmammalian Feedback Physiological Homeodomain Proteins Mitosis Phosphorylation Protein Processing Post-Translational Protein Serine-Threonine Kinases
Partial structure investigation of the traditional bulk metallic glass Pd40Ni40 P20
Shinya Hosokawa, Jean François Bérar, Nathalie Boudet, Wolf Christian Pilgrim, László Pusztai, Satoshi Hiroi, Kenji Maruyama, Shinji Kohara, Hidemi Kato, Henry E. Fischer, Anita Zeidler
Aug 28, 2019
Local structures of Pd40Ni40P20 bulk metallic glass were investigated by combining anomalous x-ray scattering close to the Pd and Ni K absorption edges, x-ray diffraction, neutron diffraction, and reverse Monte Carlo...
Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish.
Catherine M Scahill, Zsofia Digby, Ian M Sealy, Sonia Wojciechowska, Richard J White, John E Collins, Derek L Stemple, Till Bartke, Marie E Mathers, E Elizabeth Patton, Elisabeth M Busch-Nentwich
Jun 20, 2018
KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes...
Animals DNA Replication Disease Models Animal Epigenesis Genetic Exome Female Gene Expression Profiling Gene Expression Regulation Neoplastic Gene Knockout Techniques Jumonji Domain-Containing Histone Demethylases Male Melanoma Mutation Proto-Oncogene Proteins B-raf RNA Messenger Sequence Analysis RNA Zebrafish Zebrafish Proteins
Homeobox B13 G84E Mutation and Prostate Cancer Risk.
Tommy Nyberg, Koveela Govindasami, Goska Leslie, Tokhir Dadaev, Elizabeth Bancroft, Holly Ni Raghallaigh, Mark N Brook, Nafisa Hussain, Diana Keating, Andrew Lee, Romayne McMahon, Angela Morgan, Andrea Mullen, Andrea Osborne, Reshma Rageevakumar, UK Genetic Prostate Cancer Study Collaborators, Zsofia Kote-Jarai, Rosalind Eeles, Antonis C Antoniou
Dec 19, 2018
BACKGROUND: The homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutation is uncertain. OBJECTIVE: To obtain...
Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.
Chey Loveday, Kevin Litchfield, Max Levy, Amy Holroyd, Peter Broderick, Zsofia Kote-Jarai, Alison M Dunning, Kenneth Muir, Julian Peto, Rosalind Eeles, Douglas F Easton, Darshna Dudakia, Nick Orr, Nora Pashayan, Alison Reid, Robert A Huddart, Richard S Houlston, Clare Turnbull
Feb 23, 2018
Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number of loci...
Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology.
Chey Loveday, Philip Law, Kevin Litchfield, Max Levy, Amy Holroyd, Peter Broderick, Zsofia Kote-Jarai, Alison M Dunning, Kenneth Muir, Julian Peto, Rosalind Eeles, Douglas F Easton, Darshna Dudakia, Nick Orr, Nora Pashayan, The PRACTICAL Consortium UK Testicular Cancer Collaboration, Alison Reid, Robert A Huddart, Richard S Houlston, Clare Turnbull
Sep 21, 2018
UNLABELLED: Testicular germ cell tumour (TGCT) is the most common cancer in young men. Multiplex TGCT families have been well reported and analyses of population cancer registries have demonstrated a four- to eightfold risk to...
Familial GWAS Genetics polygenic risk score Testicular germ cell tumour Biomarkers Tumor Case-Control Studies Environment Genetic Predisposition to Disease Genome-Wide Association Study Heredity Humans Life Style Male Multifactorial Inheritance Neoplasms Germ Cell and Embryonal Pedigree Phenotype Polymorphism Single Nucleotide Risk Assessment Risk Factors Testicular Neoplasms
A high-resolution mRNA expression time course of embryonic development in zebrafish.
Richard J White, John E Collins, Ian M Sealy, Neha Wali, Christopher M Dooley, Zsofia Digby, Derek L Stemple, Daniel N Murphy, Konstantinos Billis, Thibaut Hourlier, Anja Füllgrabe, Matthew P Davis, Anton J Enright, Elisabeth M Busch-Nentwich
Feb 12, 2018
We have produced an mRNA expression time course of zebrafish development across 18 time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos. Using poly(A) pulldown stranded RNA-seq and a 3'...
Comprehensive functional annotation of 77 prostate cancer risk loci.
Dennis J Hazelett, Suhn Kyong Rhie, Malaina Gaddis, Chunli Yan, Daniel L Lakeland, Simon G Coetzee, Ellipse/GAME-ON consortium, PRACTICAL Consortium, Brian E Henderson, Houtan Noushmehr, Wendy Cozen, Zsofia Kote-Jarai, Rosalind A Eeles, Douglas F Easton, Christopher A Haiman, Wange Lu, Peggy J Farnham, Gerhard A Coetzee
Sep 08, 2018
Genome-wide association studies (GWAS) have revolutionized the field of cancer genetics, but the causal links between increased genetic risk and onset/progression of disease processes remain to be identified. Here we report the...
Alleles Chromatin Enhancer Elements Genetic Gene Expression Regulation Neoplastic Genetic Predisposition to Disease Genome-Wide Association Study Humans Linkage Disequilibrium Male Molecular Sequence Annotation Oligonucleotide Array Sequence Analysis Polymorphism Single Nucleotide Prostatic Neoplasms Response Elements Risk Factors Transcription Factors
Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis.
Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk.
Robert J Macinnis, Daniel F Schmidt, Enes Makalic, Gianluca Severi, Liesel M Fitzgerald, Matthias Reumann, Miroslaw K Kapuscinski, Adam Kowalczyk, Zeyu Zhou, Benjamin Goudey, Guoqi Qian, Quang M Bui, Daniel J Park, Adam Freeman, Melissa C Southey, Ali Amin Al Olama, Zsofia Kote-Jarai, Rosalind A Eeles, John L Hopper, Graham G Giles, UK Genetic Prostate Cancer Study Collaborators
Oct 07, 2016
Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma.
Amit Sud, Hauke Thomsen, Giulia Orlando, Asta Försti, Philip J Law, Peter Broderick, Rosie Cooke, Fadi Hariri, Tomi Pastinen, Douglas F Easton, Paul DP Pharoah, Alison M Dunning, Julian Peto, Federico Canzian, Rosalind Eeles, Zsofia Kote-Jarai, Kenneth Muir, Nora Pashayan, Daniele Campa, Per Hoffmann, Markus M Nöthen, Karl-Heinz Jöckel, Elke Pogge von Strandmann, Anthony J Swerdlow, Andreas Engert, Nick Orr, Kari Hemminki, Richard S Houlston
Nov 21, 2018
The BARCODE1 Pilot
Sarah Benafif, Holly Ni Raghallaigh, Eva McGrowder, Edward J Saunders, Mark N Brook, Sibel Saya, Reshma Rageevakumar, Sarah Wakerell, Denzil James, Anthony Chamberlain, Natalie Taylor, Matthew Hogben, Barbara Benton, Lucia D'Mello, Kathryn Myhill, Christos Mikropoulos, Hywel Bowen-Perkins, Imran Rafi, Michelle Ferris, Andre Beattie, Shophia Kuganolipava, Tamsin Sevenoaks, Juliet Bower, Pardeep Kumar, Steven Hazell, Nandita M deSouza, Antonis Antoniou, Elizabeth Bancroft, Zsofia Kote-Jarai, Rosalind Eeles
Jul 21, 2021
OBJECTIVES: To assess the feasibility and uptake of a community-based prostate cancer (PCa) screening programme selecting men according to their genetic risk of PCa. To assess the uptake of PCa screening investigations by men...
The BARCODE1 Pilot
Sarah Benafif, Holly Ni Raghallaigh, Eva McGrowder, Edward J. Saunders, Mark N. Brook, Sibel Saya, Reshma Rageevakumar, Sarah Wakerell, Denzil James, Anthony Chamberlain, Natalie Taylor, Matthew Hogben, Barbara Benton, Lucia D’Mello, Kathryn Myhill, Christos Mikropoulos, Hywel Bowen‐Perkins, Imran Rafi, Michelle Ferris, Andre Beattie, Shophia Kuganolipava, Tamsin Sevenoaks, Juliet Bower, Pardeep Kumar, Steven Hazell, Nandita M. deSouza, Antonis Antoniou, Elizabeth Bancroft, Zsofia Kote‐Jarai, Rosalind Eeles
Aug 16, 2021
Published by: BJU International
An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk.
Lang Wu, Yaohua Yang, Xingyi Guo, Xiao-Ou Shu, Qiuyin Cai, Xiang Shu, Bingshan Li, Ran Tao, Chong Wu, Jason B Nikas, Yanfa Sun, Jingjing Zhu, Monique J Roobol, Graham G Giles, Hermann Brenner, Esther M John, Judith Clements, Eli Marie Grindedal, Jong Y Park, Janet L Stanford, Zsofia Kote-Jarai, Christopher A Haiman, Rosalind A Eeles, Wei Zheng, Jirong Long, PRACTICAL Consortium, CRUK Consortium, BPC3 Consortium, CAPS Consortium, PEGASUS Consortium
Aug 11, 2021
It remains elusive whether some of the associations identified in genome-wide association studies of prostate cancer (PrCa) may be due to regulatory effects of genetic variants on CpG sites, which may further influence...
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