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Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Julia Ast, Anastasia Arvaniti, Nicholas HF Fine, Daniela Nasteska, Fiona B Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J Jones, Maria A Lucey, Shugo Sasaki, Daniel I Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D'Agostino, Frank Reimann, Francis C Lynn, Christopher A Reissaus, Amelia K Linnemann, Elisa D'Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J Hodson
Jan 29, 2020
The glucagon-like peptide-1 receptor (GLP1R) is a class B G protein-coupled receptor (GPCR) involved in metabolism. Presently, its visualization is limited to genetic manipulation, antibody detection or the use of probes that...
Amino Acid Sequence Animals Brain Cell Line Fluorescent Dyes Glucagon-Like Peptide-1 Receptor HEK293 Cells Human Embryonic Stem Cells Humans Islets of Langerhans Mice Mice Knockout Microscopy Fluorescence Multiphoton Models Molecular Molecular Structure Peptide Fragments Signal Transduction Tissue Distribution
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Julia Ast, Anastasia Arvaniti, Nicholas H F Fine, Daniela Nasteska, Fiona B Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J Jones, Maria A Lucey, Shugo Sasaki, Daniel I Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D'Agostino, Frank Reimann, Francis C Lynn, Christopher A Reissaus, Amelia K Linnemann, Elisa D'Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J Hodson
Feb 25, 2020
Published by: Nature Communications
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Jan 23, 2021
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
Julia Ast, Anastasia Arvaniti, Nicholas H. F. Fine, Daniela Nasteska, Fiona B. Ashford, Zania Stamataki, Zsombor Koszegi, Andrea Bacon, Ben J. Jones, Maria A. Lucey, Shugo Sasaki, Daniel I. Brierley, Benoit Hastoy, Alejandra Tomas, Giuseppe D’Agostino, Frank Reimann, Francis C. Lynn, Christopher A. Reissaus, Amelia K. Linnemann, Elisa D’Este, Davide Calebiro, Stefan Trapp, Kai Johnsson, Tom Podewin, Johannes Broichhagen, David J. Hodson
Oct 08, 2020
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
Properties of cryogenic and low temperature composite materials – A review
This paper reviews the literature published since 1994 related to the behaviour of composite materials at low and cryogenic temperatures. The material properties addressed are: tensile, compressive and shear strength, elastic...
Properties of cryogenic and low temperature composite materials – A review
This paper reviews the literature published since 1994 related to the behaviour of composite materials at low and cryogenic temperatures. The material properties addressed are: tensile, compressive and shear strength, elastic...
High fidelity analysis to predict failure in T-joints
Composite T-joints and similar skin-stiffener joints have a central role in aerospace structures. However, their accurate numerical analysis is still a great challenge due to their complex geometry and stress state during...
Novel filler materials for composite out-of-plane joints
In the manufacture of the out-of-plane joints of composite stiffened panels, such as the connection between skin and T, I, omega shaped stiffeners, a filler material is needed to fill the void between the flanges, web and skin....
Novel filler materials for composite out-of-plane joints
In the manufacture of the out-of-plane joints of composite stiffened panels, such as the connection between skin and T, I, omega shaped stiffeners, a filler material is needed to fill the void between the flanges, web and skin....
High-throughput discovery of novel developmental phenotypes.
Mary E Dickinson, Ann M Flenniken, Xiao Ji, Lydia Teboul, Michael D Wong, Jacqueline K White, Terrence F Meehan, Wolfgang J Weninger, Henrik Westerberg, Hibret Adissu, Candice N Baker, Lynette Bower, James M Brown, L Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J Daly, James M Denegre, Brendan Doe, Mary E Dolan, Sarah M Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R Horner, Chih-Wei Hsu, Sara J Johnson, Sowmya Kalaga, Lance C Keith, Louise Lanoue, Thomas N Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L McElwee, Susan Newbigging, Lauryl MJ Nutter, Kevin A Peterson, Ramiro Ramirez-Solis, Douglas J Rowland, Edward Ryder, Kaitlin E Samocha, John R Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B West, Leeyean Wong, Atsushi Yoshiki, International Mouse Phenotyping Consortium, Jackson Laboratory, Institut Clinique de la Souris (ICS) Infrastructure Nationale PHENOMIN, Charles River Laboratories, MRC Harwell, Toronto Centre for Phenogenomics, Wellcome Trust Sanger Institute, RIKEN BioResource Center, Daniel G MacArthur, Glauco P Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C Skarnes, Monica J Justice, Helen E Parkinson, Mark Moore, Sara Wells, Robert E Braun, Karen L Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R Mark Henkelman, Steve DM Brown, David J Adams, KC Kent Lloyd, Colin McKerlie, Arthur L Beaudet, Maja Bućan, Stephen A Murray
Oct 22, 2020
Approximately one-third of all mammalian genes are essential for life. Phenotypes resulting from knockouts of these genes in mice have provided tremendous insight into gene function and congenital disorders. As part of the...