Structural Analyses of Murine Histocompatibility Antigens

Robert Julian Milner

OAI: oai:digitalcommons.rockefeller.edu:student_theses_and_dissertations-1538

The major histocompatibility antigens are the predominant cell surface molecules recognized by the immune system in the rejection of grafts between individuals of the same species. The genes coding for the histocompatibility antigens are extremely polymorphic; the products of different alleles are defined serologically. The studies described in this thesis were carried out on the major histocompatibility (H-2) antigens of the mouse. The goals of these studies were to define the structure of the H-2 molecule in solution and on the cell surface and to compare the structures of different H-2 molecules to provide some insight into the nature of the genetic polymorphism.

Life Sciences