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Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
B Lo, ADE Swafford, KA Shafer-Weaver, LF Jerome, L Rakhlin, DR Mathern, CA Callahan, P Jiang, LJ Davison, HE Stevens, CL Lucas, J White, R von Borstel, JA Todd, MJ Lenardo
OAI: oai:www.repository.cam.ac.uk:1810/241569
Abstract
Clinical Research Prevention Autoimmune Disease Diabetes 4.2 Evaluation of markers and technologies 4.1 Discovery and preclinical testing of markers and technologies 4 Detection screening and diagnosis Metabolic and endocrine Animals Autoantibodies Diabetes mellitus Type 1 Disease Progression Electrochemistry Female Humans Insulin Antibodies Insulin-Secreting Cells Luminescent Measurements Mice Mice Inbred NOD ROC Curve Radioligand Assay Reproducibility of Results Sensitivity and Specificity