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Probing of a human proteome microarray with a recombinant pathogen protein reveals a novel mechanism by which hookworms suppress B-cell receptor signaling.
Leon Tribolet, Cinzia Cantacessi, Darren A Pickering, Severine Navarro, Denise L Doolan, Angela Trieu, Huang Fei, Yang Chao, Andreas Hofmann, Robin B Gasser, Paul R Giacomin, Alex Loukas
OAI: oai:www.repository.cam.ac.uk:1810/245613
Abstract
B cell CD79A Na-ASP-2 Necator americanus SCP/TAPS antigen receptor hookworm host–pathogen interaction protein microarray Adult Ancylostomatoidea Animals Antigens Helminth B-Lymphocytes CD79 Antigens Cells Cultured Down-Regulation Helminth Proteins Hookworm Infections Host-Pathogen Interactions Humans Leukocytes Mononuclear Middle Aged Phosphatidylinositol 3-Kinases Pre-B Cell Receptors Protein Array Analysis Proteome RNA Messenger Recombinant Proteins Signal Transduction Transcription Genetic Up-Regulation src-Family Kinases