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Critical residues involved in Toll-like receptor 4 activation by cationic lipid nanocarriers are not located at the lipopolysaccharide-binding interface.
Caroline Lonez, Kate L Irvine, Malvina Pizzuto, Boris I Schmidt, Nick J Gay, Jean-Marie Ruysschaert, Monique Gangloff, Clare E Bryant
OAI: oai:www.repository.cam.ac.uk:1810/248425
Abstract
Activation mechanism Cationic lipid nanoparticle Species Specificity Toll-like receptor Amino Acid Sequence Animals Binding Sites HEK293 Cells Horses Humans Lipid Metabolism Lipopolysaccharide Receptors Lipopolysaccharides Lymphocyte Antigen 96 Mice Models Molecular Molecular Docking Simulation Recombinant Fusion Proteins Signal Transduction Species Specificity Toll-Like Receptor 4