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Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations.
Mariangela Iovino, Sylvia Agathou, Ana González-Rueda, Martin Del Castillo Velasco-Herrera, Barbara Borroni, Antonella Alberici, Timothy Lynch, Sean O'Dowd, Imbisaat Geti, Daniel Gaffney, Ludovic Vallier, Ole Paulsen, Ragnhildur Thóra Káradóttir, Maria Grazia Spillantini
OAI: oai:www.repository.cam.ac.uk:1810/249092
Abstract
FTDP-17T IPSC-derived neurons MAPT gene mutations microtubule-associated protein tau Neurofibrillary Tangles Adult Aged Case-Control Studies Cell Line Cells Cultured Female Gene Expression Regulation Developmental Humans Immunohistochemistry Induced Pluripotent Stem Cells Infant Newborn Male Microscopy Confocal Microtubules Middle Aged Neurons Patch-Clamp Techniques Protein Isoforms RNA Messenger Reverse Transcriptase Polymerase Chain Reaction Tauopathies ALPHA-SYNUCLEIN tau Proteins